This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
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This page lists substances that can be used for psychonautics. See list of pharmaceuticals for medical use of substances (e.g. antidotes, nootropics, and antipsychotics). Also, please don't add entries without existing articles here, add (or merge the current ones) to list/substances-drafts instead. |
Psychedelics 
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Classical psychedelics
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Lysergamides
-
Base tryptamines
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Substituted tryptamines
- 4-AcO-DET
- 4-AcO-DiPT
- 4-AcO-DMT (Psilacetin)
- 4-AcO-MET
- 4-AcO-MiPT
- 4-HO-DET
- 4-HO-DiPT
- 4-HO-DPT
- 4-HO-EPT
- 4-HO-MET (Metocin)
- 4-HO-MiPT
- 4-HO-MPT
- 5,6-MDO-DMT
- 5-MeO-DALT
- 5-MeO-DiPT (Foxy)
- 5-MeO-DMT
- 5-MeO-MiPT (Moxy)
- Baeocystin (4-PO-NMT)
- Bufotenin (5-HO-DMT)
- Ibogaine
- Psilocin (4-HO-DMT)
- Psilocybin (4-PO-DMT)
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Mescaline homologues
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2C-x
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2C-T-x
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2C-x derivatives
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DOx
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DOx derivatives
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N-Benzyl phenethylamines
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Miscellaneous phenethylamines
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Others
- 5-MeO-DiBF
- Efavirenz
- Mirtazapine (Remeron)
Entheogens 
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- Argyreia nervosa (Hawaiian Baby Woodrose)
- Acacia confusa
- Amanita muscaria
- Ayahuasca
- Banisteriopsis caapi
- Blue Lotus
- Cannabis
- Changa
- Datura
- Iboga
- Ipomoea tricolor (Morning Glory)
- Mimosa hostilis
- Peyote
- Psilocybin mushrooms
- Salvia divinorum
- San Pedro
- Syrian rue
- Yopo
- Nicotiana
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β-Carbolines
Dissociatives 
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Arylcyclohexylamines
- 2-Fluorodeschloroketamine (2-FDCK)
- 2'-Oxo-PCE (O-PCE)
- 2'-Oxo-PCM (Deschloroketamine, DCK)
- 3-Cl-PCP
- 3-HO-PCE
- 3-HO-PCP
- 3-MeO-PCE
- 3-MeO-PCMo
- 3-MeO-PCP
- 4-MeO-PCP
- Eticyclidine (PCE)
- Hydroxetamine (HXE)
- Ketamine
- R-Ketamine (Arketamine)
- S-Ketamine (Esketamine)
- Methoxetamine (MXE)
- Phencyclidine (PCP)
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Morphinans
- Dextromethorphan (DXM)
- Dextrorphan (DXO)
- Dextromethorphan (DXM)
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Diarylethylamines
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Adamantanes
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Others
- Ibogaine
- Nitrous oxide (N2O)
- Xenon
Deliriants 
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Tropane alkaloids
- Atropine
- Hyoscyamine
- Scopolamine (Hyoscine)
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Antihistamines
- Diphenhydramine (Benadryl, DPH)
- Promethazine
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Others
- Benzydamine
- Mirtazapine (Remeron)
- Myristicin (Nutmeg)
Cannabinoids 
-
Phytocannabinoids
Non-psychoactive phytocannabinoid that often are converted to psychoactive counterparts:[1]
Quasi-psychedelic phytocannabinoids:
- delta-8-THC
- THC (delta-9-THC)
- delta-10-THC
- delta-11-THC
- THCB
- THCH
- THCP
Semi-synthetic phytocannabinoids with quasi-psychedelic effects:
-
Synthetic cannabinoids
Miscellaneous 
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κ-Opioid receptor agonists
-
Oneirogens
- 5-Hydroxytryptophan (5-HTP)
- Acetylcholine boosters
- Acetylcholinesterase inhibitors
- Calea ternifolia (Calea zacatechichi)
- Entada rheedii (African dream herb)
- Galantamine
- Melatonin
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Polysubstance combinations
-
Inhalants
- Chloroform
- Diethyl ether (Ether)
- Nitrous oxide (N2O)
- Alkyl nitrites (Poppers)
- Xenon
-
Sigmaergics
- DXM
- Memantine
- Progesterone
- Various
Miscellaneous
-
Various
Depressants 
-
Alcohols
- Alcohol (Ethanol)
- 2-Methyl-2-butanol (2M2B)
-
Benzodiazepines
- Alprazolam (Xanax)
- Bromazepam
- Clonazepam (Klonopin)
- Clonazolam
- Diazepam (Valium)
- Diclazepam
- Flualprazolam
- Flubromazepam
- Flubromazolam
- Flunitrazepam (Rohypnol)
- Flunitrazolam
- Lorazepam (Ativan)
- Lormetazepam
- Midazolam (Dormicum)
- Nifoxipam
- Pyrazolam
- Temazepam
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Thienodiazepines
-
Barbiturates
-
GABAA-α1 agonists
- Gaboxadol
- Ibotenic acid
- Muscimol
- Zolpidem (Ambien)
- Zopiclone
- Eszopiclone (Lunesta)
-
Other GABAergics
- 1,4-Butanediol (1,4-B)
- Baclofen
- Carisoprodol (Soma)
- F-Phenibut
- GABA
- GBL
- GHB (Sodium oxybate)
- Kava
- Methaqualone (Quaalude)
- Nitromethaqualone
- Phenibut
-
Gabapentinoids
- F-Phenibut
- Gabapentin
- Phenibut
- Pregabalin (Lyrica)
-
Opioids
- Acetylfentanyl
- Buprenorphine
- Codeine
- Desomorphine (Krokodil)
- Dextropropoxyphene
- Diacetylmorphine (Heroin)
- Dihydrocodeine
- Ethylmorphine
- Fentanyl
- Hydrocodone (Vicodin)
- Hydromorphone (Dilaudid)
- Kratom
- Methadone
- Morphine
- O-Desmethyltramadol (O-DSMT)
- Oxycodone (OxyContin)
- Oxymorphone
- Pethidine
- Sufentanil
- Tapentadol
- Tianeptine
- Tramadol
- U-47700
-
Others
- Clonidine
- Diphenhydramine (Benadryl, DPH)
- Mirtazapine (Remeron)
- Tizanidine
Stimulants 
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Amphetamines
- 2-FA
- 2-FEA
- 2-FMA
- 3-FA
- 3-FEA
- 3-FMA
- 4-FA
- 4-FMA
- Amphetamine (Adderall)
- Dextroamphetamine (Dexedrine)
- Ephedrine
- Fenethylline (Captagon)
- Lisdexamfetamine (Vyvanse)
- Methamphetamine (Meth)
-
Phenmetrazines
-
Phenidates
- 3,4-CTMP (3,4-DCMP)
- 4F-EPH
- 4F-MPH
- Ethylphenidate (EPH)
- Isopropylphenidate (IPH / IPPH)
- Methylnaphthidate (HDMP-28)
- Methylphenidate (Ritalin)
- Dexmethylphenidate (Focalin)
-
Cathinones
- 3-MMC
- Butylone (βk-MBDB)
- Cathinone (Khat)
- Ephylone (N-Ethylpentylone)
- Ethcathinone (ETH-CAT)
- Ethylone (βk-MDEA)
- Hexedrone
- Mephedrone (4-MMC)
- Methcathinone
- Methylone (βk-MDMA)
- Mexedrone
- N-Ethylhexedrone (HEX-EN)
- N-Ethylpentedrone (NEP)
- Pentedrone
-
Pyrrolidinophenones
-
Piperazines
-
Tropanes
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Aminorexes
-
Xanthines
-
Others
- 2-AI
- Bromantane
- Desoxypipradrol (2-DPMP)
- Methiopropamine
- Nicotine
- NM-2-AI
- Phenethylamine
- Prolintane
- Propylhexedrine (Benzedrex)
Nootropics 
-
Eugeroics
- Adrafinil
- Modafinil
- N-Methylbisfluoromodafinil (Modafiendz)
-
Dietary supplements
-
Racetams
-
Others
Neurotransmitters
-
Amino acids
- γ-Aminobutyric acid (GABA)
- L-Glutamate
-
Monoamines
- Dopamine
- Epinephrine (Adrenaline)
- Histamine
- Melatonin
- Norepinephrine (Noradrenaline)
- Serotonin (5-HT)
-
Trace amines
- Catecholamines
- Phenethylamines
- Tryptamine
- Serotonin (5-HT)
-
Peptides
-
Other