This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
THJ-2201 (1-[(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone) is a synthetic cannabinoid and analog of AM-2201. It has been marketed by many research chemical vendors as a legal alternative to the popular AM-2201, which had been banned in 2011.
Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-2201 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.
THJ-2201, or 1-[(5-fluoropentyl)-1H-indazol-3-yl](naphthalen-1-yl)methanone, is a synthetic cannabinoid drug containing a substituted indazole group. This indazole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with 5F-PB-22 and 5F-AKB48. Additionally, the indazole core is substituted at R3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings, and is also found in THJ-018. The carbonyl bridge of THJ-2201 classifies it as a ketone. THJ-2201 is an analog of AM-2201 in which the core indole structure is substituted with an indazole base.
Pharmacology
Although this substance has not been formally studied, from analysis of the structure, it is presumed that THJ-2201 has a similar binding profile to that of AM-2201 and matches many of the in vivo properties of Δ9-THC. As with AM-2201, this compound is believed to act as a potent full agonist to the central CB1 and peripheral CB2 receptors with Ki values of 1.0 and 2.6nM respectively. However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Spontaneous tactile sensations - The "body high" of THJ-2201 can be described as a warm, soft, pleasurable, all-encompassing tingling sensation that spreads over the body after initial ingestion. It maintains a consistent presence that quickly rises with the onset and hits its limit once the peak has been reached before immediately dissipating.
Sedation - Generally, the effects on the user's energy levels are primarily sedating. This encourages one to relax, and (at higher doses) fall asleep. This can, however, be suppressed by simply forcing oneself to engage in physical activities.
Motor control loss - This substance causes a partial to moderate suppression of motor control which intensifies proportional to dose but rarely results in a complete inability to walk and perform basic movements.
Appetite enhancement - As with many other cannabinoids, THJ-2201 causes an increase in appetite[1], known colloquially as "the munchies" in popular American and United Kingdom culture. Clinical studies and survey data have found that cannabis increases food enjoyment and interest in food.[2] This is thought to be due to the way in which endocannabinoids in the hypothalamus activate cannabinoid receptors that are responsible for maintaining food intake.[2]
Vasodilation - Cannabinoids appear to decrease blood pressure by dilating the blood vessels, increasing blood flow throughout the body. The arteries in the eyeball expand from the decreased blood pressure, and the heart rate increases to compensate for the reduction in pressure.
Pain relief - Cannabinoids have been clinically demonstrated to provide pain relief via agonism of cannabinoid receptors CB1 and CB2, which extends to synthetic cannabinoid receptor agonists.[3][4]
Changes in gravity - THJ-2201 can cause vertigo with which the environment appears to be spinning or oscillating. At moderate to high doses, it can spontaneously induce the sensation of falling, which can be overwhelming and uncomfortable.
Nausea - THJ-2201 can induce feelings of nausea at strong to heavy doses, which can potentially lead to vomiting.
Abnormal heartbeat - This compound, like all cannabinoids, has commonly been reported to induce tachycardia in some individuals.
Dehydration- This is known colloquially as "cotton mouth" in popular American and United Kingdom culture.
Geometry - As reported with other cannabinoids, THJ-2201 can produce closed eye visuals at moderate doses, which can escalate into visual distortions such as a ripples in the field of vision upon continuous administration. Within users who also regularly use psychedelics, it is capable of inducing these consistently in a visual style which seems to be an averaged out depiction of all the psychedelics one has used within the past. These rarely extend beyond level 4 and are considered to be mild, fine, small and zoomed out but brighter and better defined than the geometry experienced with cannabis.
Cognitive effects
Emotion enhancement - The most prominent cognitive component of cannabinoids is the way in which they enhance the emotions one is already feeling proportional to dose. This can result in euphoria, extreme laughter, and increased immersion within tasks and activities, or it can result in anxiety and paranoia depending on the user's current state of mind.
Psychosis - The prolonged usage of synthetic cannabinoids may increase one's disposition to psychosis[5], particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[6][7][8]
Tinnitus - Studies have implied that cannabinoids can exacerbate the condition of tinnitus in some individuals.[9] Subjectively, this particular compound is more likely to induce this at strong to heavy doses.
Combinational effects
Psychedelics - When used in combination with psychedelics, cannabinoids are capable of intensifying and extending the duration of both the visual and cognitive effects with extreme efficiency. This should be used with caution if one is not experienced with psychedelics.
Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced.
Alcohol - When used in combination with alcohol, cannabinoids can cause feelings of extreme nausea, dizziness and changes in gravity. It is recommended that people smoke before drinking and not the other way around unless they are extremely cautious.
The toxicity and long-term health effects of recreational THJ-2201 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because THJ-2201 has very little history of human usage. Anecdotal evidence from people who have tried THJ-2201 within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer moderate to severe anxiety or fall asleep.
It has often been recommended that those with severe pre-existing mental conditions should not ingest these substances due to the way they strongly increase one's current state of mind and emotions. Also, like THC, prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis[5], particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[6][7][8]
As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience.
As with other synthetic cannibanoids, the chronic use of THJ-2201 can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of THJ-2201 develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). THJ-2201 presents cross-tolerance with [[Cross-tolerance::all cannabinoids]], meaning that after the consumption of THJ-2201 all cannabinoids will have a reduced effect.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Stimulants increase anxiety levels and the risk of thought loops which can increase Effect:Paranoia leading to negative experiences
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Stimulants increase anxiety levels and the risk of thought loops which can increase Effect:Paranoia leading to negative experiences
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Lithium is commonly prescribed in the treatment of bipolar disorder; however, there is a large body of anecdotal evidence that suggests taking it with cannabinoids can significantly increase the risk of psychosis and seizures. As a result, this combination should be strictly avoided.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Cannabis can intensify the overall effects of psilocybin mushrooms, possibly leading to a bad trip.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]]
Legal status
THJ-2201 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in most of the world.
Denmark: As of August 25, 2015, THJ-2201 is listed on the list of controlled drugs in Denmark.[10]
Germany: THJ-2201 is controlled under Anlage II BtMG (Narcotics Act, Schedule II)[11] as of December 13, 2014.[12] It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[13]
Latvia: THJ-2201 is a Schedule I controlled substance.[14]
Sweden: THJ-2201 is a controlled substance in Sweden.[15]
Switzerland: THJ-018 is a controlled substance specifically named under Verzeichnis E.[16]
United Kingdom: THJ-2201 is a Class B controlled substance under the third-generation synthetic cannabinoids generic definition, which came into effect on December 14, 2016 and is illegal to possess, produce, supply, or import.[17]
United States: THJ-2201 is a Schedule I controlled substance.[18]
