This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
List of pharmaceuticals
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This page lists modern pharmaceuticals that varies wildly by country, and are often prescribed.
Indication
- † On the WHO Model List of Essential Medicines
- ‡ On the Anatomical Therapeutic Chemical (ATC) Classification System (controlled by the World Health Organization Collaborating Centre for Drug Statistics Methodology (WHOCC))
Keep in mind that injection vials (or crushed and filtered tablets, see safer injection guide) are preferred over oral products, to treat severe agitation and anxiety.
Antidepressants
-
Atypical
- Agomelatine
- Bupropion (Wellbutrin)
- Lamotrigine
- Mirtazapine (Remeron)
- Tianeptine
- Trazodone
-
SSRI
- Citalopram
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Fluvoxamine
- Paroxetine (Paxil)
- Sertraline (Zoloft)
- Citalopram
-
SNRI
- Atomoxetine (Strattera)
- Desvenlafaxine
- Venlafaxine (Effexor)
-
Tricyclic antidepressants
-
MAOI/RIMA
Common medicine 
-
Antipsychotics
- First generation
- Chlorprothixene (Truxal)
- Haloperidol (Haldol)
- Levomepromazine (Nozinan)
- Prochlorperazine
- Promazine
- Second generation (atypical antipsychotics)
- Aripiprazole (Abilify)
- Clotiapine (Entumine)
- Clozapine
- Olanzapine (Zyprexa)
- Quetiapine (Seroquel)
- Risperidone (Risperdal)
- First generation
-
Nonspecific antidotes
Activated charcoal † -- for orally ingested substances
-
Specific antidotes
- Acetylcysteine †
- For acetaminophen overdose
- Atropine
- Antidotes and other substances used in poisonings †
- Antidote for nicotine poisoning
- Calcium gluconate †
- Deferoxamine †
- Dimercaprol †
- Ethanol
- For methanol toxicity
- Flumazenil
- For benzodiazepine overdose
- Fomepizole †
- For methanol toxicity
- Methylthioninium chloride (methylene blue) †
- Note: A MAOI sold as dying agent (easy to obtain)
- Nalmefene
- For opioid overdose
- Naloxone †
- For opioid overdose
- Penicillamine †
- Physostigmine: For overdose on deliriants (e.g. diphenhydramine)
- Prussian blue †
- Sodium bicarbonate
- Tricyclic antidepressant (TCA) poisoning: Antidote[1]
- Caffeine overdose: Prevention of tachycardia (resting heart rate over 100 BPM).[2]
- Sodium calcium edetate
- Sodium nitrite †
- Sodium thiosulfate †
- Succimer †
- Acetylcysteine †
-
Afinils
-
Anticonvulsants/antiepileptics
- Carbamazepine †
- Diazepam † -- Adults: Severe acute anxiety or agitation: 10 mg IV or IM injection.[3]
- Ethosuximide †
- Lamotrigine †
- Lorazepam †
- Magnesium sulfate †
- Midazolam †
- Phenobarbital †
- Phenytoin †
- Valproic acid †
-
Antihypertensive drugs
Antidotes to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A agonist drugs such as 25I-NBOMe, DOB, and Bromo-DragonFLY)
- Ketanserin ‡ (for hypertension caused by serotonergic agents)
- Sodium nitroprusside †, nitroprusside ‡. Nonsympatholytic vasodilatory antihypertensives
- Tolazoline ‡ (for hypertension caused by adrenergic agents
-
Antipsychotics
First-Generation (Typical) Antipsychotics:
- Chlorpromazine †‡
- Haloperidol (Haldol) †‡
- Prochlorperazine ‡
Second-Generation (Atypical) Antipsychotics:
- Clozapine †‡
- Fluphenazine †‡
- Olanzapine (Zyprexa) ‡
- Risperidone (Risperdal) †‡
- Quetiapine (Seroquel) ‡
Third-Generation
- Aripiprazole (Abilify) ‡
- Brexpiprazole ‡
- Cariprazine ‡
- Lurasidone (Latuda) ‡
-
Anxiolytics
- Benzodiazepines
- Alprazolam (Xanax)‡
- Diazepam †‡
- Benzodiazepines
-
Serotonin syndrome treatment
-
SSRIs
-
Misc
- Antidementia agent: Ergoloid
-
Combination drugs
- Deudextromethorphan/quinidine (d-DXM/Q) (see also: DXM)
- Dextromethorphan/bupropion (Auvelity) (see also: DXM)
- Dextromethorphan/quinidine (Nuedexta) (see also: DXM)
Recreational/entheogenic use
This list is synchronized with Erowid Pharmaceutical Vaults.
Substances frequently used outside indication. They may be used in conjunction with other substances (example, MAOIs), or produce a different effect than indicated in heavy doses.
Unsorted
-
- Bupropion
- MAOI: Pharmahuasca is a pharmaceutical version of the entheogenic brew ayahuasca. Traditional ayahuasca is made by brewing the MAOI-containing Banisteriopsis caapi vine with a DMT-containing plant, such as Psychotria viridis. Pharmahuasca refers to a similar combination that uses a pharmaceutical MAOI instead of a plant.
Cannabinoids 
-
Phytocannabinoids
- Cannabidiol (CBD) (oral): Firstly: Vaped or smoked CBD heated to 250-300 C will partially be converted to THC.[5] Thus it's inconvenient to smoke or vape CBD to relieve a THC toxicity. Secondly: 50 times more CBD than THC is needed to reduce acute effects of THC,[6] which makes it practically impossible to administer proper dosage by inhalation. Also, the quantity of CBD converted into THC will increase a lot with the required ratio, and excessive harshness in the lungs may escalate a bad trip.
- Tetrahydrocannabinol (THC)
Miscellaneous 
Depressants 
-
Misc
-
Benzodiazepines
- Alprazolam (Xanax)
- Clonazepam (Klonopin)
- Diazepam (Valium)
- Etizolam
- Flunitrazepam (Rohypnol)
- Lorazepam (Ativan)
- Midazolam
- Oxazepam
- Phenazepam
- Temazepam
- Triazolam
-
Thienodiazepines
-
Barbiturates
-
Opioids
- Buprenorphine
- Codeine
- Dextropropoxyphene (Darvon)
- Diacetylmorphine (Diamorphine / Heroin)
- Dihydrocodeine
- Ethylmorphine (pharmaceutical?)
- Fentanyl
- Hydrocodone (Vicodin)
- Hydromorphone (Dilaudid)
- Methadone
- Morphine
- Oxycodone (Oxycontin)
- Oxymorphone (Opana)
- Pethidine (Meperidine)
- Sufentanil
- Tapentadol
- Tramadol
-
GABAergics
-
Gabapentinoids
Stimulants 
-
Amphetamines
-
Phenidates
- Isopropylphenidate (IPH / IPPH)
- Methylnaphthidate (HDMP-28)
- Methylphenidate (Ritalin / MPH)
-
Xanthines
-
Tropanes
-
Others
- Bromantane
- Nicotine
- Propylhexedrine (Benzedrex)
Nootropics 
See also
External links
References
- ↑ Bruccoleri, RE; Burns, MM (March 2016). "A Literature Review of the Use of Sodium Bicarbonate for the Treatment of QRS Widening". Journal of medical toxicology : official journal of the American College of Medical Toxicology. 12 (1): 121–9. doi:10.1007/s13181-015-0483-y. PMC 4781799
. PMID 26159649.
- ↑ https://www.ncbi.nlm.nih.gov/books/NBK532910/
- ↑ (PDF) https://www.regionkronoberg.se/contentassets/7fd21479ae564476a1b8639e9519ede9/diazepam-hameln.pdf. Missing or empty
|title=(help) - ↑ 4.0 4.1 Sporer, KA (August 1995). "The serotonin syndrome. Implicated drugs, pathophysiology and management". Drug safety. 13 (2): 94–104. doi:10.2165/00002018-199513020-00004. PMID 7576268.
- ↑ Czégény, Z; Nagy, G; Babinszki, B; Bajtel, Á; Sebestyén, Z; Kiss, T; Csupor-Löffler, B; Tóth, B; Csupor, D (26 April 2021). "CBD, a precursor of THC in e-cigarettes". Scientific reports. 11 (1): 8951. doi:10.1038/s41598-021-88389-z. PMID 33903673.
- ↑ Englund, A., Oliver, D., Chesney, E., Chester, L., Wilson, J., Sovi, S., De Micheli, A., Hodsoll, J., Fusar-Poli, P., Strang, J., Murray, R. M., Freeman, T. P., McGuire, P. (16 November 2022). "Does cannabidiol make cannabis safer? A randomised, double-blind, cross-over trial of cannabis with four different CBD:THC ratios". Neuropsychopharmacology: 1–8. doi:10.1038/s41386-022-01478-z. ISSN 1740-634X. Retrieved 25 November 2022.