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Sigmaergics
Sigmaergics are a group of compounds that bind to sigma receptors in the body and brain. They have only been discovered recently and their function is currently not entirely known. There are two types of sigma receptors, σ1 and σ2.
An unusually wide variety of substances bind to sigma receptors from almost all major pharmalogical classes. Some of the notable compounds that bind to sigma receptors include:
- (+)-3-PPP
- 3-MeO-PCP
- 4C-T-2
- 5-MeO-DMT
- AC-927
- Amitriptiline
- Berberine
- Chlorphenamine
- Citalopram
- Cocaine
- DMT
- DPT
- DHEA
- Dextrallorphan
- DXM
- DiPT
- Diacetylmorphine
- Donezepil
- Haloperidol
- Hypericin
- Ibogaine/Noribogaine
- Lamotrigine
- Memantine
- Methamphetamine
- Methoxetamine
- Methylphenidate
- Methylphenylpiracetam
- Morphine
- Naloxone
- Naltrexone
- Neuropeptide Y
- Noscapine
- PCP
- PRE-084
- Pregnenolone
- Progesterone
- Promethazine
- Propanolol
- Quinidine
- R-Ketamine (S-Ketamine has not been found to bind to sigma receptors)
- Saffron
- Selegiline
- Sertraline
- TMA
- Tapentadol
- Venlafaxine
- W-18