This is an unofficial archive of PsychonautWiki as of 2025-08-08T03:33:20Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
Allylescaline
4-Allyloxy-3,5-dimethoxyphenethylamine (also known as allylescaline) is a lesser-known novel psychedelic substance of the phenethylamine class. It is a structural analog of mescaline and related to escaline and methallylescaline. It is relatively uncommon and has little to no history of human usage.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
The effects of this compound were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 20 – 35 mg orally and describes the duration of action to be 8 - 12 hours.[1]
Very little data exists about the pharmacological properties, metabolism, and toxicity of allylescaline. It is highly advised to use harm reduction practices if using this substance.
Allylescaline, or 4-allyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino -NH2 group through an ethyl chain. Escaline contains two methoxy functional groups CH3O- which are attached to carbons R3, and R5 and an additional allyloxy group at carbon R4 of the phenyl ring. Allylescaline is the 4-allyloxy analog of mescaline.
Allylescaline, also referred to as 4-allyloxy-3,5-dimethoxyphenethylamine, is research compounds that is not well-known. The IUPAC name for Allylescaline is 4-Allyloxy-3,5-dimethoxyphenethylamine 4-Allyloxy-3,5-dimethoxy-1-ethylami with the molecular formula being C13H19NO3 and a molecular weight of 237.29 g/mol. Allylescaline is known to have an average mass of 237.294998 Da and a monoisotopic mass of 237.136002 Da.
Allylescaline acts as a 5-HT2Apartial agonist. The psychedelic effects are believed to come from allylescaline's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
It is the 4O-allyl homolog of mescaline, and binds similarly to the serotonin receptors. It seems to have considerably increased potency by weight, with an active dose in humans reported to be 20-40 mg (compared to 300-400 mg for mescaline).
It is relatively uncommon and has little to no history of human usage. Very little data exists about the pharmacological properties, metabolism, and toxicity of allylescaline. The effects of this compound were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - In terms of its effects on the physical energy levels of the user, allylescaline is usually considered to be very energetic and stimulating without being forced. For example, when taken in any environment it will usually encourage physical activities such as running, walking, climbing or dancing. In comparison, other more commonly used psychedelics such as psilocin or LSA are generally sedating and relaxed.
Spontaneous tactile sensations - The "body high" of allylescaline can be characterized as proportionally very intense in comparison to its accompanying visual and cognitive effects. It is manifested in a number of forms including an intense soft, warm glow that grows over the body and is capable of becoming extremely physically euphoric. This is contrasted by a pleasant yet sharp electric sensation that moves up and down the body.
Tactile enhancement - Allylescaline causes enhanced tactile sensations at all doses. Notably, allylescaline causes awareness of every sensation and every nerve ending in the body once level 8A geometry is reached.
Physical euphoria - Relative to other psychedelics, allylescaline has been noted for the physically euphoric aspect that is vaguely reminiscent of other phenethylamines. In high or excessive dosages this effect can be diminished by uncomfortable physical side effects.
Increased libido - When it occurs, this effect is mild to moderate
Nausea - Mild to extreme nausea is commonly reported and either passes instantly once the user has vomited or gradually fades by itself as the peak sets in.
There are currently 0 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
The toxicity and long-term health effects of recreational allylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because allylescaline is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried allylescaline suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Allylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of allylescaline is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Allylescaline presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of allylescaline all psychedelics will have a reduced effect.
As such, it may contain incomplete or wrong information. You can help by expanding it.
Germany: Allylescaline is controlled under Anlage I BtMG (Narcotics Act, Schedule I)[2] as of February 1, 1997[3] (called "4-Allyloxy-3,5-dimethoxy-phenethylazan"). It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[4]
Japan: Allylescaline is a controlled substance in Japan effective March 25th, 2015.[5]
Sweden: Allylescaline is illegal in Sweden as of January 2016.[6]
Switzerland: Allylescaline is a controlled substance specifically named under Verzeichnis E.[7]
United Kingdom: It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[8]
