Fatal overdose may occur when benzodiazepines are combined with other depressants such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.[1]

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Summary sheet: Lormetazepam

Lormetazepam (trade name Nocatmid or Loretam) is a depressant substance of the benzodiazepine class. Lorazepam is used for the short-term treatment of, insomnia, acute seizures, and the sedation of hospitalized patients.[2][3][4][5] Lormetazepam (sold commercially as Noctamid, Sedalam, Ergocalm and others) is a short acting depressant benzodiazepine to intermediate acting 3-hydroxy benzodiazepine derivative and temazepam analogue.

It's used for the short-term treatment of moderate to severe insomnia, and to induce sleep in pre- and postoperative periods.

  1. Risks of Combining Depressants - TripSit 
  2. benzo.org.uk : Benzodiazepines and their effects, Professor Ian Hindmarch, January, 1997 
  3. Cox, C. E., Reed, S. D., Govert, J. A., Rodgers, J. E., Campbell-Bright, S., Kress, J. P., Carson, S. S. (March 2008). "An Economic Evaluation of Propofol and Lorazepam for Critically Ill Patients Undergoing Mechanical Ventilation". Critical care medicine. 36 (3): 706–714. doi:10.1097/CCM.0B013E3181544248. ISSN 0090-3493. 
  4. Walker, M. (24 September 2005). "Status epilepticus: an evidence based guide". BMJ : British Medical Journal. 331 (7518): 673–677. ISSN 0959-8138. 
  5. Battaglia, J. (1 June 2005). "Pharmacological Management of Acute Agitation". Drugs. 65 (9): 1207–1222. doi:10.2165/00003495-200565090-00003. ISSN 1179-1950.