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Meclofenoxate, also known as Centrophenoxine or Lucidril is a nootropic that acts as a precursor to choline. It is a an ester of Dimethylaminoethanol and para-chlorophenoxyacetic acid.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Mecolofenoxate was developed in 1959 at the French National Scientific Research Center.[citation needed]
Meclofenoxate has been tested as alzheimers treatment.[1] Additionally it has been shown to invrease the life span of mice by up to 29.5%.[2]
Pharmacology
A portion of Meclofenoxate breaks down into DMAE and pCPA. DMAE is then converted to choline.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Body odor alteration - This can be caused in some populations, especially those suffering from trimethylaminuria. Choline (a metabolite of meclofenoxate) is a precursor to trimethylamine, which those with trimethylaminuria are not able to easily break down, oftening resulting in smelling similar to fish.
Wakefulness - In comparison to citicoline, meclofenoxate manifests itself primarily in a physically stimulating manner over a mental stimulation.
Experience reports
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
Meclofenoxate is non-addictive, is not known to cause harm, and has an extremely low toxicity relative to dose. Similar to many other nootropic substances, there are relatively few physical side effects associated with acute choline exposure. Various studies have shown that in reasonable doses in a particular context, it presents no negative cognitive, psychiatric or toxic physical consequences of any sort.
Regardless, it is strongly recommended that one is familiar with and uses harm reduction practices when using this substance.
Tolerance and addiction potential
Dangerous interactions
In vitro studies of meclofenoxate showed inhibition of total MAO, MAO A and MAO B in rat brains.[4] Meclofenoxate and MAOIs are a potentially dangerous combination. It is likely that MAOIs could increase the effects of meclofenoxate unpredictably. Taking this chemical while on prescription MAOIs is strongly discouraged.
↑Malík, Matěj; Tlustoš, Pavel (2022-08-17). "Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs". Nutrients. 14 (16): 3367. doi:10.3390/nu14163367. ISSN2072-6643. PMID36014874.
↑Hochschild, R. (1973). "Effect of dimethylaminoethyl p-chlorophenoxyacetate on the life span of male swiss webster albino mice". Experimental Gerontology. 8 (4): 177–183. doi:10.1016/0531-5565(73)90024-7.
. ISSN 2072-6643. PMID 36014874.