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Talk:Glaucine
Revision as of 23:41, 16 December 2023 by >HmmChonkMilk(Added some to pharm)
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Glaucine is a naturally occurring novel psychedelic substance of the aporphine class found in Glaucium Flavum.[1] Glaucine has one stereocenter, therefore it has two stereoisomers, where (S)-Glaucine is a 5-HT2Aagonist and (R)-Glaucine is a 5-HT2 positive allosteric modulator.[2] Its psychedelic effects are believed to be produced by its interaction with serotoninreceptors like most psychedelics do, but also has clinically significant interactions at D1,[3] α1, and benzothiazepine receptors as an antagonist, and inhibits MOA to a moderate degree.[4] Glaucine has a close relative found in Blue Lotus (Nymphaea nouchali) called apomorphine. It is both psychedelic as well as sedating, but the sedation is more similar to that of opioids than psilocybin, a generally sedating psychedelic. It is most commonly consumed orally.
Glaucine is rarely sold on the streets and almost exclusively distributed as a legal alternative to more common psychedelics, where it is commonly used for recreational and entheogenic purposes. It was and still is a very uncommon and unheard of substance with sparing experiences on the internet.
Due to its potent sedating effects as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Glaucine was first described in 1839 by Probst, defined as an 'acrid alkaloid, and was first isolated by Richard Fischer in 1901.[6] It has been used used for millennia, where records back to the year 131 claim it was used for aches and sores as well as abscess' in present-day Turkey.[6] In an overview study in 2007, glaucine's antitussive effectiveness was confirmed along with its potent bronchodilation effects, but lacked the respiratory depression and habit-forming use associated with opioid antitussives.[7] Today, it is sold as an antitussive medicine in Iceland and eastern European countries, as well as being used off-label for asthma.[8]
As a result, it may contain incomplete or wrong information. You can help by expanding it.
Chemistry
Glaucine is an aporphine, meaning 'not morphine.' It is named this because despite similar structure to morphine, it is in fact not morphine. Aporphine is the parent compound of glaucine, where glaucine has methoxy groups substituted at the 1, 2, 9, and 10 positions. Glaucine has one stereocenter, meaning it has two stereoisomers. Both stereoisomers are found in nature, albeit in different plants.[9]
Glaucine is a sedative-psychedelic. The psychedelic effects perceived from glaucine are in fact from interaction of 5-HT2A receptors, but both stereoisomers of glaucine interact with the receptor differently. (S)-glaucine is an agonist of the receptor, the same action performed by psychedelics like LSD and mescaline, but (R)-glaucine is a positive allosteric modulator, meaning it boosts the signaling and activity at the receptor.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
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This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
