Talk:Olanzapine

Summary sheet: Olanzapine

Olanzapine
Chemical Nomenclature
Common names	Olanzapine, Zyprexa
Systematic name	[[systematic name::2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine]]
Class Membership
Psychoactive class	Antipsychotic
Chemical class	Thienobenzodiazepine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Bioavailability 60 - 65% Threshold 1 mg Light 2.5 - 5 mg Common 5 - 10 mg Strong 10 - 15 mg Heavy 15 mg + Duration Total 6 - 8 hours Onset 40 - 60 minutes Peak 1.5 - 6 hours Offset 8 - 12 hours After effects 20 - 24 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Olanzapine, first branded as Zyprexa, is a widely-used antipsychotic substance of the thienobenzodiazepine chemical class. It produces sedating and neuroleptic effects when administered. Olanzapine can be given by mouth and can also be injected into a muscle. Olanzapine might be useful as a trip aborter, especially for stimulants, as it blocks the action of dopamine.

Chemistry

Olanzapine is a thienobenzodiazepine. It includes a piperazine moiety at R₄.

Olanzapine is classified as a thienobenzodiazepine derivative. Its chemical structure consists of a fused tricyclic system incorporating a thiophene ring and a diazepine ring. Specifically, olanzapine features a piperazine substituent at the R4 position of the diazepine moiety. This piperazine ring is believed to contribute to its affinity for various neurotransmitter receptors, particularly serotonergic and dopaminergic sites. The compound has a molecular formula of C17H20N4OS, with a molecular weight of 312.44 g/mol. Its IUPAC name is 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine. Syrex1013 (talk) 00:26, 27 June 2025 (UTC)

Pharmacology

Olanzapine is known to cause weight gain and induce diabetes mellitus type 2 more frequently than other antipsychotics. However, it is less likely to produce tardive dyskinesia or an extrapyramidal reaction. It appears to be an effective treatment for schizophrenia.

Subjective effects

Physical effects

• • Hunger - This often happens over a course of treatment and not with one use.
  • Sedation - This effect is more often uncomfortably tiring than relaxing.
  • Salivation
  • Muscle relaxation
  • Motor control loss
  • Dizziness
  • Perception of bodily heaviness
  • Headaches
  • Extrapyramidal symptoms

Cognitive effects

• • Anxiety suppression - This is mediated by olanzapine's antidopaminergic, antiadrenergic, and antiserotonergic action rather than GABA-related activity.
  • Emotionality suppression - Olanzapine dulls and suppresses emotions.
  • Focus suppression or enhancement - This often depends on the mental state of the individual.
  • Decreased libido
  • Sleepiness
  • Cognitive euphoria - This effect is extremely rare. Olanzapine is often a dulling, "boring" pharmaceutical.
  • Cognitive dysphoria - This often includes a sense of boredom or depression accompanied by uncomfortable sedation.

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

• Erowid Experience Vaults: Olanzapine

External links

• Olanzapine (Wikipedia)
• Olanzapine (Erowid Vault)
• Olanzapine (DrugBank)
• Olanzapine (Drugs.com)