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alpha-Pyrrolidinohexiophenone (also known as PV-7, alpha-PHP, A-PHP, and α-PHP) is a lesser-known novel stimulant substance of the cathinone class. It is structurally related to MDPV and is one of the successors to the designer drugcathinone analog α-PVP.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
It is being used and marketed as a replacement for α-PVP (known on the street as flakka) a few years following its ban, where it has come to substitute α-PVP in many parts of the world. While initially mass synthesized in Chinese industrial laboratories, a ban on α-PHP within China's borders has forced production to nations worldwide.[citation needed]
Very little data exists about the pharmacological properties, metabolism, and toxicity of α-PHP. It has recently become commonly marketed alongside research chemicalstimulants like NEP and Hexen as a legal, grey-market alternative to a-PVP, and commercially distributed through online research chemical vendors.
α-PHP, or α-Pyrrolidinohexanophenone, is a compound of the substituted cathinone and substituted pyrrolidine chemical classes. Its structure is comprised of hexanal bound to a phenyl ring at the 1 position and the nitrogen of a pyrrolidine ring at the 2 position.
α-PHP is the longer chain homolog of α-PVP, possessing an additional carbon on the alkyl side chain.
Pharmacology
The mechanism of action of α-PHP is unknown. Aside from a substantially shorter duration, it is believed to act similarly to the designer drugpentedrone and α-PVP, which both act as a potent norepinephrine-dopaminereuptake inhibitors (NDRI),[1] although no substantial research on the pharmacology of this compound has yet been conducted.
This means it may effectively boost the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulating and euphoric effects.
Subjective effects
In comparison to its predecessor α-PVP, this compound has been reported as inducing slightly less anxiety, uncomfortable side effects, euphoria, and an easier comedown.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation - α-PHP can be considered to be extremely stimulating and energetic, although less so than α-PVP. This encourages activities such as running, climbing and dancing, although it can also encourage sitting immobile and engaging in repetitive tasks. The particular style of stimulation which α-PHP presents can be described as forced. This means that at higher dosages it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in an extreme unsteadiness of the hands and a general lack of motor control.
Spontaneous physical sensations - The "body high" of α-PHP can be described as a moderate to extreme euphoric tingling sensation that encompasses the entire body. It is capable of becoming overwhelming at higher dosages. This sensation maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Tactile enhancement - α-PHP can enhance one's sense of touch to extreme degrees, often leading to states of sexual arousal.
Vibrating vision - A person's eyeballs may begin to spontaneously wiggle back and forth in a rapid motion, causing vision to become blurry and temporarily out of focus (a condition known as nystagmus).
Focus enhancement - α-PHP has been noted as enhancing focus, but in a way that leaves the user totally fixated on whatever task at hand, however trivial.
Mouth numbing - In a similar fashion to that of cocaine this compound numbs the areas of the body which it touches, these areas can include the nostrils, gums, mouth and throat of the user.
Abnormal heartbeat - Due to the potency of its rush, α-PHP can cause various uncomfortable or painful sensations in the heart, especially when abused or used for extended periods. Those with familial or personal heart issues are discouraged from using this drug in its most potent routes of administration.
Increased blood pressure - α-PHP, especially when it is vaporized or injected, can lead to sudden spikes of blood pressure that may manifest in an extremely uncomfortable "exploding heart" sensation.
Dehydration - Dry mouth and dehydration are a universal experience with α-PHP and are a product of an increased heart rate, adrenergic activity and the motivation to engage in strenuous physical activities. While it is important to avoid becoming dehydrated, especially when out dancing in a hot environment, there is a potential possibility of suffering from water intoxication through over-drinking. Therefore it is advised that users simply sip at water and be mindful of their water in-take.
Difficulty urinating - Higher doses of α-PHP result in an overall difficulty when it comes to urination, an effect that is temporary and typically harmless.
Headaches - This typically can occur towards the end of the experience, but can sometimes happen during one as well.
The cognitive effects of α-PHP can be broken down into several components which progressively intensify proportional to dosage. The ample head space of α-PHP is described by many as one of extreme mental stimulation and powerful euphoria. It contains a large number of typical stimulant cognitive effects, particularly those of the cathinone or pyrrolidine classes of drugs.
The most prominent of these cognitive effects generally include:
Cognitive euphoria - A euphoria very similar to amphetamine or cocaine is present as well as feelings of well-being and contentedness which are likely a direct result of serotonin and dopamine accumulation in the brain's reward pathways.
Analysis enhancement - Users report that this effect typically only occurs at low doses, and becomes increasingly more impairing as one increases their intake.
Anxiety & Paranoia - α-PHP can lead to states of extreme anxiety and paranoia when dosed too highly or frequently, which is why eyeballing this substance is strongly discouraged. The anxiety and paranoia this compound produces shares many features of the paranoia that can be induced by methamphetamine or cocaine, and typically happens during the come down phase of the experience.
Feelings of impending doom - This typically is experienced when the substance is abused, but can happen at higher than needed doses, or the comedowns of binges. It can also happen spontaneously, although this tends to be rare.
Compulsive redosing - While a high tendency to compulsive redose is a hallmark of this class of drug, α-PHP has been reported as being slightly less compulsive than its predecessor α-PVP. Nevertheless, users are advised to use extreme caution in not losing control when on this drug.
Motivation enhancement - This effect provides short-lived states of extreme motivation, but due to the cognitively narrowing aspects of its action, rarely ever translates into productive action.
Increased libido - α-PHP, like its predecessor α-PVP can induce states of extreme sexual arousal due to its powerful disinhibiting effects
Time distortion - Strong feelings of time compression are common within α-PHP and increase in the perception of perceived experience is greatly increased
Psychosis - This compound may induce psychosis if it is compulsively binged upon for prolonged periods of time. However, the likelihood of psychosis on this compound has been reported to be noticeably less than that of A-PVP.
After effects
The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. It has been reported that this crash is usually not considered as severe as it is on A-PVP at equivalent dosages. The effects commonly include, but are not limited to:
There are currently 1 experience reports describing the effects of this substance in our experience index. You can also submit your own experience report using the same link.
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational α-PHP use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because α-PHP has very little history of human usage. Anecdotal evidence from people who have tried α-PHP within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
α-PHP has been reported to be the cause, or a significant contributory cause, of death in suicides and overdoses caused by combinations of drugs.[2]
As with other short-lived highly dopaminergic stimulants, the chronic use of α-PHP can be considered highly addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of α-PHP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). α-PHP presents cross-tolerance with [[Cross-tolerance::all dopaminergicstimulants]], meaning that after the consumption of α-PHP all stimulants will have a reduced effect.
α-PHP, like other strongly dopaminergic stimulants, can result in a stimulant psychosis that may present with a variety of symptoms (e.g., paranoia, hallucinations, or delusions).[3][4] A review on treatment for amphetamine, dextroamphetamine, and methamphetamine abuse-induced psychosis states that about 5–15% of users fail to recover completely.[4][5] The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve the symptoms of acute amphetamine psychosis.[4]
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
"[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] & "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 25x compounds are highly stimulating and physically straining. Combinations with A-PHP should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
"[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
"[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
"[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
"[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - A-PHP may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
"[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Tramadol is known to lower the seizure threshold[6] and combinations with stimulants may further increase this risk.
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.
Internationally, α-PHP was added to the UN Convention on Psychotropic Substances as a Schedule II controlled substance in March 2020.[8][9]
Austria: α-PHP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
Brazil: As of September 7, 2018, all cathinone analogues are controlled substances considered illegal to possess, use and distribute. This was made possible due to a blanket ban law appended to Portaria SVS/MS nº 344.[10]
China: α-PHP is a controlled substance in China as of October 2015.[11]
Germany: α-PHP is a controlled substance under the BtmG (Betäubungsmittelgesetz)[12] as of Dezember 21, 2022.[13] Possession, production, sales and consumption is illegal and penalized.
Italy: The President of the Republic of Italy classified cathinone and all structurally derived analogues (including pyrovalerone analogues) as Narcotics in January 2012. [14]
Netherlands: As of October 29, 2021, α-PHP has been banned in the Netherlands under the 1971 Vienna Convention on Psychotropic Substances. [15]
Sweden: α-PHP is classified as narcotic substance.[16]
Switzerland: α-PHP can be considered a controlled substance as a defined derivative of Cathinone under Verzeichnis E point 1. It is legal when used for scientific or industrial use.[17]
United Kingdom: is a Class B drug in the United Kingdom as a result of the cathinone catch-all clause.[18]
United States: α-PiHP has been assigned to Schedule I on a Temporary Placement basis. This order, which extends the temporary scheduling order that DEA previously issued for these substances (84 FR 34291, July 18, 2019), is effective July 18, 2021 and expires on July 18, 2022. .[19] As such, the sale or the use of this compound is prohibited.
↑Hofmann, F. G. (1983). A handbook on drug and alcohol abuse: the biomedical aspects (2nd ed ed.). Oxford University Press. ISBN9780195030563.CS1 maint: Extra text (link)
↑Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN1937-6995. ISSN1556-9039. OCLC163567183.
↑"AnlageII BtmG" (in Deutsch). Bundesministerium der Justiz und für Verbraucherschutz.Text "urlhttps://www.gesetze-im-internet.de/btmg_1981/anlage_ii.html" ignored (help); Missing or empty |url= (help); |access-date= requires |url= (help)
. eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647.