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2C-T-2
Revision as of 08:50, 12 November 2017 by >David Hedlund(Isomer Design)
2,5-Dimethoxy-4-ethylthiophenethylamine (also known as 2C-T-2, and Rosy) is a psychedelicphenethylamine of the 2C-x family. It was first synthesized and tested for activity in humans by Alexander Shulgin and his research group in 1981.[1] Shulgin described the synthesis and activity of 2C-T-2 in his 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[2]
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
This particular substance is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which, with the exception of mescaline he developed and synthesized himself. They can be found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.[3]
Anecdotal reports tend to characterize 2C-T-2 as a highly dose sensitive psychedelic known for its strong visuals, lucid headspace and unpredictably intense body load.
Following the initial positive results found by Shulgin's research group, a more formal study was carried out by psychedelic psychotherapy pioneer by Myron J. Stolaroff who was interested in evaluating the potential use of 2C-T-2 in psychotherapy.[4] Based on the experiences of forty participants in the study who took 2C-T-2, Stolaroff compared the effects favorably to MDMA, describing it as more emotionally opening and permitting a wider exploration of feelings and thoughts. Although presenting a very positive evaluation of the drug, Stolaroff also noted that because it permitted repressed feelings to surface more readily than MDMA, the experience could be uncomfortable for some users.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has little history of human usage. Many reports also indicate that the physical effects are too severe for those who are not already experienced with psychedelics or suffer from pre-existing physical conditions as it is known to cause powerful nausea and general bodily discomfort that may dominate the rest of the experience. It is highly advised to approach this potent, physically unpredictable, and long-lived psychedelic substance with the proper amount of precaution and harm reduction practices if choosing to use it.
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Chemistry
Generic structure of a phenethylamine molecule
2C-T-2, or 2,5-dimethoxy-4-ethylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-T-2 belongs to the 2C family of phenethylamines which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T-2 is also substituted at R4 with an ethyl thioether group.
2C-T-2 is a close structural analogue of 2C-T-7; the two differ by the length of the alkane chain in their thioether functional group.[5]
The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.
Athough no established scientific experiments have been performed to establish MAO-A inhibition of 2C-T-2, phenethylamine derivatives substituted with an alkylthio group at the 4 position (such as 2C-T-7, 4-MTA, and the 2,5-desmethoxy derivative of 2C-T-7) are known to act as selective monoamine oxidase A inhibitors. Therefore, this substance may likewise have MAOI effects.[6]
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Spontaneous tactile sensations - The "body high" of 2C-T-2 can be described as very intense and uncomfortable in comparison to 2C-E or 2C-B. In high doses, it's capable of causing painful cramping. It is similar yet distinct from the "body high" experienced on 2C-T-7, but is considered much more unpleasant. The sensation itself can be described as intense and may manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
Stimulation - In terms of its effects on the physical energy levels of the user, 2C-T-2 is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of other phenethylamines such as 2C-B, 2C-E and 2C-P.
Bodily control enhancement - Although this component is capable of manifesting itself in a distinct and noticeable fashion for most users, it does not generally seem to be as apparent or intense as the same component found within LSD and 2C-B.
Nausea - Extreme nausea is commonly reported when consumed in moderate to high doses and either passes once the tripper has vomited or gradually fades by itself as the peak sets in. It can be described as very painful and violent in comparison to 2C-T-7 or 2C-E.
Drifting(melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in appearance and extremely realistic in style but with a subtle digital/cartoon-like form.
The visual geometry that is present throughout this experience can be described as somewhat similar in appearance to that of ayahuasca, psilocin, and 4-AcO-DMT with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of LSD or 2C-E. 2C-T-2's geometry can be comprehensively described through its variations as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in-depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of DOC or 2C-P. Higher doses are more likely to result in states of level 8B visual geometry, but may also lead into level 8A visual geometry (as with 2C-T-7).
Hallucinatory states
At common to high doses, 2C-T-2 is capable of producing a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamines family. These effects include:
External hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as ayahuasca, 2C-T-2 is very high in external hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact manifested as dense solidified geometric matter or physical objects of imagined concepts. They are more common within dark environments and can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-T-2 is very high in hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
Cognitive effects
The head space of 2C-T-2 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high doses.
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
The toxicity and long-term health effects of recreational 2C-T-2 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried 2C-T-2 within the psychedelic community suggests that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.
It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose.
Tolerance and addiction potential
2C-T-2 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 2C-T-2 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-2 presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 2C-T-2 all psychedelics will have a reduced effect.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
If 2C-T-2 does have MAOI effects as has been speculated,[citation needed] this could indicate that 2C-T-2 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[7] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:
United Kingdom.: 2C-T-2 is a Class A substance, making it illegal to possess, manufacture, or import.
United States: 2C-T-2 is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.
Australia: 2C-T-2 is illegal in Australia as of 2005.
Belgium: 2C-T-2 was added to the list of illegal psychotropic substances on Nov 8, 2004.
Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[8]
Denmark: 2C-T-2 was added to category B of the controlled substances list on August 23, 2003.[9]
European Union: EU Council published an order on Dec 6, 2003, asking all member states to control 2C-I, 2C-T-2, 2C-T-7, and TMA-2.
Germany: The drug is on list I / the highest level of control, making it unable to be prescribed, manufactured, or possessed as of Oct 7, 1998.[10]
Italy: 2C-T-2 was added to the "Tabella 1" in a Jan 11, 2005 Ministry of Health statement.
Japan: 2C-T-2 is controlled as a "Designated Substance" (Shitei-Yakubutsu) by the Pharmaceutical Affairs Law, making it illegal to possess or sell
Latvia: 2C-T-2 is a Schedule I controlled substance.[11]
Netherlands: It was classified as an unregistered pharmaceutical as of April 12, 1999. Unlicensed manufacture, sale, import, trade and possession of this substance can be prosecuted.
Switzerland: Possession, production and sale is illegal.[12]
China - As of October 2015 2C-T-2 is a controlled substance in China.[13]
Canada: 2C-T-2 would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[14]
↑Stolaroff, MJ; Wells, C. Preliminary results with new psychoactive agents 2C-T-2 and 2C-T-7. In Jahrbuch für Ethnomedizin und Bewußtseinsforschung (Yearbook of Ethnomedicine and the Study of Consciousness); Rätsch, C; Baker, J, Eds., 1993; Vol. 2, pp 99–117. (MAPS.org) | http://www.maps.org/images/pdf/1993_stolaroff_1.pdf
↑Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
↑Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
↑"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.CS1 maint: Unrecognized language (link)
