Substituted phenidates

Substituted phenidates (also known as phenidates) are a class of chemicals that include compounds that typically produce traditional stimulant effects. Pharmacologically, they tend to act as reuptake inhibitors of the monoamine neurotransmitters dopamine and norepinephrine, and occasionally serotonin.

Generic structure of a phenidate molecule.

Chemistry

Substituted phenidates are a chemical class based upon the molecule methylphenidate. The molecular structure of methylphenidate is comprised of a phenethylamine core with a carbon chain substitution at the R_α position that links to the R_N position, forming a piperidine ring. It also includes a substitution at the R_β position of methyl acetate.

List of substituted phenidates

Compound	R3	R4	RO	Structure
Methylphenidate	H	H	CH3
Ethylphenidate	H	H	CH2CH3
Isopropylphenidate	H	H	CH(CH3)2
Propylphenidate	H	H	CH2CH2CH3
4-Methyl Methylphenidate	H	CH3	CH3
3,4-CTMP	Cl	Cl	CH3
4F-MPH	H	F	CH3
4F-EPH	H	F	CH2CH3
Methylnaphthidate (HDMP-28)	CH=CH-	CH=CH-	CH3
Ethylnaphthidate	CH=CH-	CH=CH-	CH2CH3

See also

• Responsible use
• Psychedelics
• Phenethylamines
• Substituted amphetamine
• Entactogens
• Stimulants