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2C-D
Revision as of 06:48, 18 June 2017 by >Unity(Added dangerous interactions.)
2,5-Dimethoxy-4-methylphenethylamine (also known as 2C-M and more commonly as 2C-D) is a synthetic psychedelic of the phenethylamine chemical class that produces short-lived psychedelic effects comparable to those produced by mescaline and other 2C-x compounds when administered. Its synthesis was first published in 1970 by a team from the Texas Research Institute of Mental Sciences.[1] Initial trials by Alexander Shulgin at sub-threshold doses in humans were carried out in 1964.[2]
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
In his book PiHKAL ("Phenethylamines I Have Known And Loved"), Shulgin lists the dosage range as being from 20 to 60 mg. This is now regarded by many as a conservative estimate as it has since been reported that substantially higher doses can be taken to induce a full spectrum of classical psychedelic effects while remaining physically benign, a relatively unique quality in the 2C-x family.
Lower doses of 2C-D (generally 10 mg or less) have been explored for its use as a potential nootropic, albeit with mixed results.[3]
Many who have experimented with this substance report that it is calmer, easier to handle and more comfortable on the body than other closely related psychedelicphenethylamines. While not especially visual or physically euphoric, it is said to be very lucid in its head-space, analytical and cognitively unimpairing.
Today, 2C-D is used both recreationally and as an entheogenic substance. It is rarely sold on the streets and almost exclusively distributed as a gray area research chemical through online vendors.
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The synthesis of 2C-D was first published in 1970 by a team from the Texas Research Institute of Mental Sciences,[4], but initial trials by Alexander Shulgin at sub-threshold doses were carried out in 1964. Further investigations at higher doses were carried out by Shulgin and his fellow researchers between 1974 and 1978.[5] The name '2C-D' derives from the chemical's structure - it is the 2-Carbon analogue of DOM.
Notably, Shulgin referred to 2C-D as a “pharmacological tofu,” meaning it can extend or potentiate the effect of other substances without coloring the experience too much, in a manner similar to how tofu absorbs the flavors of sauces or spices it is cooked with.[citation needed] While some people have claimed 2C-D is relatively uninteresting as a psychedelic on its own many users have come to strongly disagree with this early assessment and believe that 2C-D is an extremely versatile and fully-fledged synthetic entheogen in its own right.
Albeit showing promise as a very functional psychostimulant[6][7] with very successful studies investigating the use in psychotherapy in Germany,[8] 2C-D has not found widespread use. This has been argued to be due to the previously limited diversity of substances on the market - a consumer dynamic which has changed significantly with the advent of the internet - allowing a broader freedom of choice for explorers of psychedelic phenethylamines.[9] Of these, it tends to be substantially harder to find and notably more expensive by weight.[citation needed]
Chemistry
Generic structure of a phenethylamine molecule
2C-D, or 2,5-dimethoxy-4-methylphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. 2C-D contains methoxy functional groups CH3O- attached to carbons R2 and R5 as well as a methyl group attached to carbon R4 of the phenyl ring.
2C-D belongs to the 2C family of phenethylamines which contain methoxy groups on the 2 and 5 positions of the benzene ring.
2C-D's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
Stimulation & Sedation - In terms of its effects on the physical energy levels of the user, the 2C-D experience begins with mild sedation that increases as the trip progresses, and lacks the distinctive energetic feeling associated with most phenethylamines.
Spontaneous physical sensations - The "body high" of 2C-D can be described as a pleasurable, all-encompassing comfort sensation. This maintains a consistent presence that steadily rises with the onset and hits its limit once the peak has been reached.
Bodily control enhancement - Whilst at lower doses one may find that their bodily control is enhanced, at higher dosages it seems to become suppressed.
Nausea - Although nausea remains present, in comparison to other phenethylamines such as 2C-E, 2C-I or 2C-B, this remains extremely mild and dissipates quickly even with higher dosages.
Drifting(melting, flowing, breathing and morphing) - In comparison to other psychedelics, this effect can be described as low in detail, slow and smooth in motion, static in appearance and realistic in style.
The visual geometry able to be produced by this substance can be described as more similar in appearance to that of DOM or 25D-NBOMe than that of LSD, 2C-B or 2C-I. It can be comprehensively described as structured in its organization, organic in style, intricate in complexity, large in style, slow and smooth in motion, colorful in scheme, bright in color, blurred in its edges and equally rounded and angular in its corners. It gives off a natural feel at higher dosages. While the final level of 2C-D geometry has yet to be formally confirmed, it seems more likely that it would result in states of level 8B visual geometry over level 8A.
Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - In comparison to other psychedelics such as LSD, 2C-D is low in hallucinations embedded within visual geometry. However, when it does occur this particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They are more common within dark environments and can be described as internal in their manifestation, lucid in believability, and interactive in style.
External hallucinations (settings, sceneries, and landscapes; alterations in perspective and scenarios and plots) - 2C-D is capable of external hallucinations embedded within visual geometry. This particular effect commonly contains hallucinations with scenarios, settings, concepts and autonomous entity contact. They can be described as external in their manifestation, lucid in believability, and fixed in style.
Cognitive effects
The head space of 2C-D is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high doses. The feeling of "unaltered consciousness" may be bothersome to trippers who want an intense experience because the head space is fairly normal, stable and therefore typically considered rather uninteresting to those new to hallucinogenic experiences.
Synaesthesia - In its fullest manifestation, this is a very rare and non-reproducible effect. Increasing the dosage can increase the likelihood of this occurring, but seems to only be a prominent part of the experience among those who are already predisposed to synaesthetic states.
There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:
The toxicity and long-term health effects of recreational 2C-D use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 2C-D is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 2C-D suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
2C-D is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 2C-D is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-D presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 2C-D all psychedelics will have a reduced effect.
Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Tramadol - Tramadol lowers the seizure threshold[10] and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them.[citation needed]
Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops and paranoia. This interaction may cause elevated risk of psychosis.[citation needed]
Lithium - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.[citation needed]
Legality
Australia: Australia has a blanket ban over all substituted phenethylamines including the entire 2C-X family.[11]
Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[12]
Canada: 2C-D would be considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[13]
China - As of October 2015 2C-D is a controlled substance in China.[14]
Denmark: 2C-D is added to the list of Schedule B controlled substances.[15]
Germany: On December 13, 2014, 2C-D was added to the controlled substance act ("BtMG"), making it illegal to produce, sell or possess.[16]
Japan: 2C-D is controlled by the Pharmaceutical Affairs Law in Japan, making it illegal to possess or sell.[17]
Latvia: 2C-D is a Schedule I controlled substance.[18]
Switzerland: Possession, production and sale is illegal.[19]
Sweden: 2C-D is classified as a health hazard as of March 1, 2005, in the regulation SFS 2005:26, making it illegal to sell or possess.[20]
United Kingdom: 2C-D is a Class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act of 1971.[citation needed]
United States: 2C-D is listed in Schedule I of section 202(c) of the Controlled Substances Act in the United States. This was signed into law as of July 2012 under the Food and Drug Administration Safety and Innovation Act.[21]
↑Zuba, D., & Sekula, K. (2013). Analytical characterization of three hallucinogenic N-(2-methoxy)benzyl derivatives of the 2C-series of phenethylamine drugs. Drug Testing and Analysis, 5(8), 634–645. https://doi.org/10.1002/dta.1397
↑Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089
↑"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.CS1 maint: Unrecognized language (link)
↑Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
