Modafinil
| Modafinil | |
|---|---|
 Modafinil's 3D molecular structure. | |
| Dosage (oral) | |
| Threshold | 0.5 - 1mg |
| Light | 1 - 1.5mg |
| Common | 1.5 - 2.5mg |
| Strong | 2.5 - 5mg |
| Heavy | 5+mg |
| Dosage (insufflated) | |
| Threshold | 0mg |
| Light | 0 - 0mg |
| Common | 0 - 0mg |
| Strong | 0 - 0mg |
| Heavy | 0 - 0mg |
| Duration (oral) | |
| Onset | 20 - 60 minutes |
| Come up | 20 - 90 minutes |
| Peak | 5 - 10 hours |
| Come down | 1 - 3 hours |
| After effects | 2 - 8 hours |
| Duration (insufflated) | |
| Onset | 0 - 0 minutes |
| Come up | 0 - 0 minutes |
| Peak | 0 - 0 hours |
| Come down | 0 - 0 hours |
| After effects | 0 - 0 hours |
Modafinil (Provigil, Alertec, Modavigil) is a wakefulness promoting agent (eugeroic) used to enhance cognition, reduce fatigue, and increase alertness. It is approved by the United States' Food and Drug Administration for treatment of obstructive sleep apnea, shift work sleep disorder, and narcolepsy. [1]
Chemistry
Pharmacology
Subjective effects
Physical Effects
Cognitive Effects
Toxicity and Harm Potential
Lethal Dosage
The median lethal dose at which 50% of participants die (LD50) from Modafinil for human beings has never been reached. No life-threatening effects have taken place in clinical trials involving the administration of 1000mg to 1600mg of Modafinil per day for 7 to 21 consecutive days. Intentional acute overdoses of 4500mg and 4000mg in two adult subjects and an accidental injestion of 800mg by a three-year-old child did not result in any life-threatening effects or death. [2] After overdosing on 5000mg of Modafinil in a suicide attempt, a fifteen-year-old female reported a severe headache, nausea, and tachycardia, but did not appear to have any lethan or long-term effects. [3]
Tolerance and Addiction Potential
Legal Issues
Modafinil is legally approved for medical purposes worldwide. However, it is illegal to sell and possess in most countries without a prescription.
- In the United States, Modafinil is a Schedule IV controlled substance. It is illegal to buy, sell, or possess the drug without a prescription or DEA license. [4]
- Modafinil is listed as a Schedule F prescription drug in Canada, meaning it can be prescribed for human and veterinary use. [5]
See Also
References
- ↑ Provigal (Manufacturer's Website) | http://www.provigil.com/
- ↑ The National Library of Medicine - PROVIGIL | http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=fd75a8a7-a8ab-4141-9af9-989a220b9c19
- ↑ Journal of Clinical Sleep Medicine - Unsuccessful Suicide Attempt of a 15 Year Old Adolescent with Ingestion of 5000 mg Modafinilhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725258
- ↑ Placement of Modafinil Into Schedule IV - U.S. Department of Justice | http://www.deadiversion.usdoj.gov/fed_regs/rules/1999/fr0127.htm
- ↑ National Association of Pharmacy Regulatory Authorities - Regulations Amending the Food and Drug Regulations (1184 — Modafinil) | http://napra.ca/Content_Files/Files/FDR-Project1184-Modafinil-Oct122006.pdf