Talk:Dangerous drug combinations/Archive 1

Negative effects

Severe

• Serotonin Syndrome
• Drug Induced Psychosis
• Delusions
• Thought loops
• Panic Attacks
• Seizures
• Loss of Consciousness(Coma)
• Major Respiratory depression
• Heart Attack/Stroke
• Death

Minor

• Anxiety
• Depression
• mood swings
• paranoia
• confusion
• Amnesia
• Sedation
• Loss of motor control
• Dizziness
• Dehydration
• Nausea
• Head aches
• Vasoconstriction
• Abnormal heart beat
• minor respiratory depression
• Loss of temperature regulation

• Thought deceleration
• Suppression of emotion
• Suppression of information processing
• Suppression of language

other to include:

• Disconnective effects: Disconnection from consciousness
• Disconnective effects: Detachment plateaus
• Time distortion

Prescription Drugs

SSRIs

If someone on SSRIs wants to take any hallucinogen, they should abstain from their SSRI for at least double the half life of their SSRI. Complications from SSRI interaction can range from decreased effects to fatal serotonin syndrome.

MAOIs

In many cases, taking an MAOI can lead to more severe negative effects from hallucinogens (although it actually improves the trip for several drugs). An MAOI can be mixed with mushrooms, mescaline, LSD or vaporized DMT safety which will increase the trip. An MAOI is needed to make DMT orally active, this combination is commonly known as ayahuasca. When taking any other hallucinogens one must abstain from MAOIs for at least double the drug's half life.

• Atypical antidepressants that have any effect on serotonin or dopamine should be treaded just as carefully as SSRIs.

Recreational drugs

Dissociatives

Alcohol, GHB/GBL, and Benzos should be avoided while on any dissociative, this can lead to nausea, vertigo and blackouts

DXM, MXE, PCP, and PCP analogs should not be mixed with any serotonin releasing agents or reuptake inhibitors; mixing it with 2C-T-7, MDMA, aMT, cocaine or amphetamine can lead to Serotonin Syndrome because of the effect of these drugs on the SERT.

Ketamine does not have any effect on the SERT and can be used safely with MDMA, however caution should still be taken when using stimulants too.

Psychedelics

DOx chemicals that cause strong vasoconstriction should not be mixed with any stimulants.

Serotonin Releasers

The main method of action on this group of drugs is releasing serotonin in the brain, as such they should be used in moderation when mixed with each other and should not be mixed with serotonin reuptake inhibitors.

Common serotonin releasers: MDMA, MDA, MDEA, 6-APB, 5-APB, MDAI, Mephedrone, Methylone

serotonin reuptake inhibiting hallucinogens: aMT, DXM

Possible Heart Risk

These combinations should be avoided if you have a history of heart complications:

• Ketamine should not be mixed with cocaine as there is a high chance of having a heart attack.