Substituted tropanes

Tropane alkaloids are a class of chemicals that include compounds with psychoactive effects.

General tropane molecule

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Chemistry

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Tropane alkaloids are molecules which contain a substituted tropane ring in their structure. Tropane is a nitrogen-containing bicyclic organic molecule, which consists of a piperidine and pyrrolidine ring fused at carbons R₁ and R₅ along with an additional methyl substitution at R_N.

Pharmacology

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Tropane alkaloids are mostly anti-cholinergics (antagonistic action on acetylcholine receptors) or stimulants (prevention of dopamine reuptake).

Examples

Tropane alkaloids are seen throughout organic chemistry and include psychoactive and anaesthetic compounds.

Anticholinergic drugs:

• Atropine
• Hyoscyamine
• Scopolamine

Stimulant drugs:

• Cocaine

See also

• Responsible use
• Deliriants
• Anti-histamines
• Stimulants
• Datura

References

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