5-APB

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5-APB (5-(2-aminopropyl)benzofuran) is a stimulant and entactogenic drug of the phenethylamine and benzofuran class. 5-APB is sometimes called Benzo Fury, although this name is also used for 6-APB as well.

5-APB
Chemical Nomenclature
Common names	5-APB
Substitutive name	5-(2-AminoPropyl)Benzofuran
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Light 40 - 60 mg Common 70 - 100 mg Strong >100 mg Duration Total 7-8 hours Onset 45 minutes DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
MAOIs
Serotonin releasers
SSRIs
5-HTP

Research on benzofurans was originally carried out by David Nichols and his team at Purdue, where they synthesized 5-APDB (the dihydrofuran analogue) around 1993.

It wasnt until 2006, however, that the pharmaceutical company  Eli Lilly and Co. had their patent for this compound granted, having originally filed it in 2006.Oddly enough, none of Nichols' work was mentioned in the patent.

Chemistry

5-APB is a benzofuran and phenethylamine, so there is the ethylamine chain attached to the 2 position of the ring. It can also classify as an amphetamine deriviative, because the ethylamine chain is alpha methylated. Molecules of the amphetamine class contain a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain with an additional methyl substitution at R_α. The oxygen in the furan ring is placed at the 5 position, which generally constitutes more stimulating effects than when the oxygen is placed at the 6 position, which is usually described as being more psychedelic in effects.

Pharmacology

5-APB is a triple reuptake inhibitor(TRI) with K_i values of 180, 265 and 811 nM for NET, DAT and SERT respectively, as well as being an agonist for the 5-HT_2A and 5-HT_2B receptors (K_i of 14nM at 5-HT_2B). It has also been speculated from the structure activity relationship(SAR) that 5-APB is a monoamine releasing agent.

Toxicity and harm potential

Interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Dangerous

• αMT
• Tramadol
• MAOIs

Unsafe

• DOx
• NBOMes
• 2C-T-x
• 5-MeO-xxT
• DXM
• PCP

Legal issues

• UK: 5-APB is a Class B drug.
• USA: Could be considered an analogue of MDA, therefore would be covered under the Federal Analogue Act if intended for human consumption.

See also

• Responsible use
• Psychedelics
• Entactogens
• Stimulants
• Phenethylamines
• Amphetamines
• MDA
• MDAI
• MDMA

External links

• 5-APB(Tripsit)
• 5-APB(Wikipedia)
• 5-APB experiences(Erowid)
• The Big and Dandy 5-APB Thread(Bluelight)