4F-MPH

4F-MPH
Chemical Nomenclature
Common names	4F-MPH, 4-FMPH
Substitutive name	4-Fluoromethylphenidate
Systematic name	Methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate
Class Membership
Psychoactive class	Stimulant
Chemical class	Phenidate
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold < 5 mg Light 5 - 10 mg Common 10 - 15 mg Strong 15 - 20 mg Heavy 20 mg + Duration Total 4 - 8 hours Onset 30 - 60 minutes Peak 2 - 4 hours Offset 1 - 2 hours After effects 5 - 10 hours ⇣ Insufflated Dosage Threshold 5 mg Light 5 - 8 mg Common 8 - 14 mg Strong 14 - 20 mg Heavy 20 mg + Duration Total 3 - 6 hours Onset 10 - 30 minutes Peak 1 - 2 hours Offset 1 - 2 hours After effects 4 - 8 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions

Summary sheet: 4F-MPH

4F-MPH (4'-fluoro-methylphenidate) is an entactogenic stimulant, substituted phenethylamine, piperidine, and close analog of methylphenidate (ritalin). The two substances have very similar pharmacological mechanisms but distinctively different subjective effects as 4F-MPH can be considered significantly more euphoric and recreational in its experience. It also acts as a higher efficiency dopamine reuptake inhibitor than the closely related methylphenidate..

4F-MPH has little to no history of human usage prior to its distribution online through research chemical vendors. It was initially developed as a replacement for ethylphenidate which became illegal in the United Kingdom on April 10, 2015 due to a temporary blanket ban. Anecdotal reports suggest that it is considerably more potent with fewer uncomfortable side effects such as anxiety, muscle spasms and compulsive redosing.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

4F-MPH is nearly identical in structure to methylphenidate (ritalin); the difference is that it has a fluorine atom bonded to the phenyl group at the 4 position. Amphetamine analogues containing fluorine, chlorine, bromine and methyl groups are typically stronger than those without.

Pharmacology

4F-MPH acts as a dopamine reuptake inhibitor, meaning it effectively boosts the levels of dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine to accumulate within the brain, resulting in stimulating and euphoric effects.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical effects

• Stimulation
• Dehydration
• Appetite suppression
• Increased heart rate

Cognitive effects

• Thought acceleration
• Analysis enhancement
• Wakefulness
• Focus enhancement - This component is most effective at low to moderate dosages as anything higher will usually impair concentration.
• Motivation enhancement
• Euphoria - The euphoric rush associated with 4F-MPH use (as result of dopamine reuptake inhibition) is very short-lived and compulsive, similar to that of cocaine.
• Cognitive fatigue - This component can occur during the offset of this compound as a rebound effect which is usually equal in its intensity to the enhancements which occurred before it.

Toxicity and harm potential

The toxicity and long-term health effects of recreational 4F-MPH use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because 4F-MPH is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried 4F-MPH suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses or using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

Tolerance and addiction potential

In terms of its tolerance, 4F-MPH can be used multiple days in a row for extended periods of time, but acute tolerance does exist and builds up gradually over repeated extended use. This results in the user requiring an increase in dosage to achieve the same effects.

4F-MPH has potential for abuse on par with that of amphetamine or MDMA due to its lack of significant tolerance, euphoric effects and action upon dopamine transporters.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] & "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 25x compounds are highly stimulating and physically straining. Combinations with 4F-MPH should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
• "[[UncertainInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
• "[[UnsafeInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - 4F-MPH may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - Tramadol is known to lower the seizure threshold and combinations with stimulants may further increase this risk.
• "[[DangerousInteraction" contains a listed "[" character as part of the property label and has therefore been classified as invalid.]] - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.
• MDMA - The neurotoxic effects of MDMA may be increased when combined with other stimulants.
• Cocaine - This combination will increase strain on the heart.

Legal issues

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

• U.S. - 4-Fluromethylphenidate is a Schedule I controlled substance in the state of Alabama.

See also

• Responsible use
• Methylphenidate
• Ethylphenidate
• Stimulant

External links

• 4F-MPH (Wikipedia)
• 4F-MPH (Bluelight)
• 4F-MPH (UK Chemical Research)