Modulator

Potentiators are a class of substance that can be used to enhance a users sensitivity to another substance. They are known to potentially cause effects on their own by interacting with endogenously produced substances. A well known example of the use of potentiators in psychonautics in the inclusion of Harmala alkaloids in Ayahuasca -a shamanic beverage

Pharmalogical Classes

Specific Compounds Nonselective MAO-A/MAO-B inhibitors Hydrazines Isocarboxazid (Marplan) Nialamide (Niamid) Phenelzine (Nardil, Nardelzine) Hydracarbazine Benmoxin (Nerusil, Neuralex) Iproclozide (Sursum) Iproniazid (Marsilid, Iprozid, Ipronid, Rivivol, Propilniazida) (discontinued worldwide except for France) Mebanazine (Actomol) Octamoxin (Ximaol, Nimaol) Pheniprazine (Catron) Phenoxypropazine (Drazine) Pivalylbenzhydrazine (Tersavid) Safrazine (Safra) Other Tranylcypromine (Parnate, Jatrosom) Caroxazone (Surodil, Timostenil) Methylene blue Linezolid Selective MAO-A inhibitors Harmala alkaloids Harmine Harmaline Other Bifemelane (Alnert, Celeport) Moclobemide (Aurorix, Manerix) Pirlindole (Pirazidol) Toloxatone (Humoryl) Minaprine (Cantor) Selective MAO-B inhibitors hordenine Rasagiline (Azilect) Selegiline (Deprenyl, Eldepryl, Emsam, Zelapar)

Botanical Sources Citrus × paradisi (Grapefruit) Peganum harmala (Syrian rue) Banisteriopsis caapi (Ayahuasca vine) Hordeum vulgare L. (Barley) Echinopsis candicans Panicum miliaceum (proso millet) Sorghum vulgare (Sorghum ) Ariocarpus fissuratus (Chautle) Passiflora incarnata (Passion Flower)