DOC
| DOC | |
|---|---|
 The skeletal formula of DOC. | |
| Dosage (oral) | |
| Threshold | 0.5 - 1mg |
| Light | 1 - 1.5mg |
| Common | 1.5 - 2.5mg |
| Strong | 2.5 - 5mg |
| Heavy | 5+mg |
| Dosage (insufflated) | |
| Threshold | 0.5mg |
| Light | 0.5 - 1mg |
| Common | 1 - 2mg |
| Strong | 2.5 - 3.5mg |
| Heavy | 3.5 - 4+mg |
| Duration (oral) | |
| Onset | 20 - 90 minutes |
| Come up | 1 - 2 hours |
| Peak | 8 - 12 hours |
| Come down | 1 - 3 hours |
| After effects | 2 - 4 hours |
| Duration (insufflated) | |
| Onset | 1 - 2 minutes |
| Come up | 10 - 20 minutes |
| Peak | 2 - 4 hours |
| Come down | 1 - 2 hours |
| After effects | 2 - 4 hours |
2,5-Dimethoxy-4-chloroamphetamine (DOC) is a psychedelic drug of the substituted phenethylamine and substituted amphetamine chemical classes.
This substance has no history of human usage prior to the 1991 publication of its synthesis and pharmacology in the PiHKAL (Phenethylamines i Have Known And Loved).[1] by Alexander Shulgin. In modern times it is used as a recreational drug and an entheogen, rarely sold on the streets and almost exclusively obtained as a grey area research chemical through the use of online vendors.
DOC is a highly dose sensitive psychedelic that is often sold on blotting paper and known for its strong visuals and intense body load. Many reports also indicate that the effects of this chemical may be overly intense for those who are not already experienced with psychedelics.
Chemistry
DOC is a substituted alpha-methylated phenethylamine, a class of compounds commonly known as amphetamines. The phenethylamine equivalent (lacking the alpha-methyl group) is 2C-C
Pharmacology
DOC's psychedelic effects are believed to come from its efficacy at the 5-HT2A receptor as a partial agonist. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects
The physical effects of DOC can be broken down into six components all of which progressively intensify proportional to dosage. These are described below and generally include:
- Spontaneous tactile sensations - The "body high" of DOC is manifested as somewhat intense in comparison to most classical psychedelics. The sensation itself can be described as a constantly present yet somewhat mild energetic pins and needles sensation that encompasses a person’s entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
- Stimulation - In terms of its effects on the physical energy levels of the tripper, DOC is usually considered to be extremely stimulating at levels which do not become overwhelming, resulting in a shakiness and unsteadiness of the hands but encouraging trippers to move around, run, dance, climb and generally engage in physical activities. In comparison, other more commonly used psychedelics such as psilocin are generally sedating and relaxed.
- Enhancement of touch - Feelings of enhanced tactile sensation are consistently present at moderate levels throughout most DOC trips.
- Nausea - Mild to extreme nausea is reported when consumed in moderate to high dosages and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.
- Vasoconstriction - This effect is usually only present at higher dosages but can be particularly uncomfortable.
- Increased bodily control
Cognitive effects
The cognitive effects of DOC are described by many as extreme mental stimulation combined with and a powerful enhancement of a person's current mental state.
The total sum of these cognitive components regardless of the setting generally includes:
- Introspection - This component is consistently manifested only in the context of a non-social setting in which the user is alone.
- Increased empathy, love and sociability - This component is consistently manifested only in the context of social settings in which one is within the company of others. These feelings of sociability, love and empathy are a little weaker and less sharp than those found on substances such as MDMA and 2C-B but still prove strong enough to provide long lasting therapeutic effects.
- Acceleration of thought
- Time distortion
- Feelings of fascination, importance and awe
- Conceptual thinking
- Connectivity of thought
- Enhancement of current mind state
- Removal of cultural filter
- Ego suppression, loss and death
Visual effects
Enhancements
DOC presents a full and complete array of possible visual enhancements which generally includes:
Distortions
DOC presents a full and complete array of possible visual distortions which generally includes:
- Drifting (Melting, Flowing, Breathing and morphing) - In comparison to other psychedelics, this effect can be described as highly detailed, slow and smooth in motion, static in their appearance and unrealistic/cartoon-like in style.
- Tracers
- After images
- Texture repetition
- Colour shifting
- Scenery slicing
The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or Ayahuasca than that of LSD, 2C-B or 2C-I. It can be comprehensively described through its variations as intricate in complexity, abstract in form, organic in feel, structured in organization, brightly lit, multicoloured in scheme, glossy in shading, sharp in edges, large in size, fast in speed, smooth in motion, equally rounded and angular in corners, unimmersive in depth and consistent in intensity. At higher dosages this geometry is significantly more likely to result in states of level 8B visual geometry over level 8A.
Hallucinatory states
DOC and other substituted amphetamines produce a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the the phenethylamine family. These effects include:
- Transformations
- Internal hallucinations (Autonomous entities, Settings, Alterations in perspective and Scenarios) - In comparison to other psychedelics such as LSD, DOC is extremely high in internal hallucinations. They are more common within dark environments and can be comprehensibly described through their variations as lucid in believability, interactive in style, new experiences in content, autonomous in controllability, geometry based in style and almost exclusively of a religious, spiritual, mystical or transcendental nature in their overall theme.
Auditory effects
The auditory effects of DOC are common in their occurrence and exhibit a full range of effects which commonly includes:
Toxicity and Harm Potential
The toxicity and long term health effects of recreational DOC use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DOC is a research chemical with very little history of human usage. Anecdotal evidence from people who have tried DOC within the psychedelic community suggests that there are no negative health effects attributed to simply trying this drug at low to moderate doses or using it very sparingly but nothing can be completely guaranteed.
Tolerance and Addiction Potential
DOC is not physically addictive and many users experience a frequency self-regulating quality to the drug. Tolerance for DOC seems to be very mild and does not build up without repeated use over a short period of time.
Legal Issues
- Denmark: DOC is a Schedule I drug.
- Finland: Possession, production and sale is illegal.
- Israel: Possession, production and sale is illegal.
- New Zealand: DOC is a Class C drug.
- Poland: DOC is not controlled in Poland and no analog law covers it.
- Germany: DOC is listed in Anlage I in Germany, making it illegal to buy, sell, or possess without a license
- Canada: DOC is Schedule III in Canada, making it illegal to sell, buy, or possess without a license.[2]
- UK: DOC is a Class A drug.
- USA: DOC is technically not scheduled in the United States, but could be considered an analogue of DOM or DOB and therefore a Schedule I drug.