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Talk:MDPHP
Revision as of 11:54, 25 January 2023 by >Somos(Added experience reports section)
MDPHP was first developed in the 1960s by a team at Boehringer Ingelheim[1]
Like other Substituted cathinones, MDPHP is associated with compulsive use and addiction. Very little data exists about the pharmacological properties, metabolism, and toxicity of MDPHP. Due to its potent psychostimulant effects and unknown toxicity profile, it is highly advised to use harm reduction practices if choosing to use this substance.
Substituted cathinones are derivatives of the naturally occurring substance cathinone, which is one of the psychoactive principles in khat (Catha edullis). Cathinone is composed of a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon.
Pharmacology
MDPHP is thought to act primarily as a potent norepinephrine-dopaminereuptake inhibitor (NDRI). Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamineneurotransmitters in the synaptic cleft, or gap between neurons. The result of this inhibition is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neuron. Serotonin also plays a role, although to a much lesser degree. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that MDPHP produces. Mainly possessing re-uptake inhibiting qualities, MDPHP could be considered more like cocaine or methylphenidate than amphetamine in method of action.[2] In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.
However, despite its structural similarity, the effects of MDPHP bear little resemblance to other methylenedioxy phenylalkylamine derivatives such as 3,4-methylenedioxy-N-methylamphetamine (MDMA), instead producing primarily stimulant effects with only mild entactogenic qualities. It is closely related to the potent stimulant MDPV though with slightly milder effects and lesser compulsive redosing cravings. Although MDPHP was already first synthetized in 1960's,[3] it has been used as an alternative in some countries following the banning of MDPV.
Subjective effects
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Physical effects
MDPHP is a strong stimulant generating a broad spectrum of phisical effects:
The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects can commonly last between 1 and 4 days and they include:
Physical fatigue - This can last some days and it can be pretty intense depending on the dosage.
Cognitive effects
The general cognitive effects of MDPHP can be described as being similar to those of other typical strong stimulants. At common dosages, the MDPHP high is described as being euphoric and rushy in its effects, causing increased motivation, sociability, sexual desire and concentration. Higher doses of MDPHP, however, can intensify numerous negative effects such as anxiety and disorganized thoughts; at extremely high doses or continued use, delusions and psychosis become likely.
Ego inflation - Similar to the ego inflation of methamphetamine, MDPHP can induce states of egomania at its peak where the user feels capable of everything.
