Talk:Autism spectrum

* What are we trying to say in that article? What's actual established science for that topic? What are things to consider? What are the implications in regard to psychonautics? Can autists be psychonauts? Or are psychedelics mostly just relaxing for them? Consider "Category:Psychiatric diagnosis" to this page if it gets moved to main space.

There are some very interesting developments in autism research which are not yet published but have been presented in several meetings. Alan Friedman, Ph.D., is a chemist who works for the Ortho Clinical Diagnostics division of Johnson & Johnson. He was interested in the opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin. This is where the rationale for the gluten-free, casein-free diet came from. Many children with autism (some but not all) do not seem to break gluten and casein down completely, but rather keep their metabolites casomorphine and gliadomorphin intact which then get into the bloodstream (and therefore into the urine).

"Opioid theory of autism - first proposed by Panksepp, confirmed by Reichelt and Shattock - which held that children with autism had many abnormal peptides (small pieces of partially broken down proteins) in their urine, including casomorphine and gliadomorphin... Autistic children studied had casomorphine and gliadomorphin unless they were on the diet. More importantly, he also found 2 other morphine-related compounds, dermorphin and deltorphin II, in the urine of these children. (Alan Friedman)"

Cannabinoids

Endocannabinoids

• Endocannabinoid Signaling in Autism
• The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models
• Role of Endocannabinoids on Neuroinflammation in Autism Spectrum Disorder Prevention
• The Endocannabinoid System and Autism Spectrum Disorders: Insights from Animal Models.

Pharmacotherapy

For substances, see Cannabinoid.

• CBD: Cannabidiol as a suggested candidate for treatment of autism spectrum disorder.

Dopamine

Endogenous dopamine

• Dopamine and the Development of Executive Dysfunction in Autism Spectrum Disorders
• A Dopamine Hypothesis of Autism Spectrum Disorder.
• Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD).

Melatonin

Endogenous melatonin

• Melatonin in Children with Autism Spectrum Disorders: How Does the Evidence Fit Together?
• Melatonin in autism spectrum disorders.
• Melatonin in autism spectrum disorders: a systematic review and meta-analysis.

Opioids

See also: [Opioid excess theory (Wikipedia)]

Endogenous opioids

• Biologically active peptide-containing fractions in schizophrenia and childhood autism.
• Brain opioids and autism: an updated analysis of possible linkages.
• Opioid peptides and dipeptidyl peptidase in autism.
• μ opioid receptor, social behaviour and autism spectrum disorder: reward matters.
• Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention.
• Opioid peptides and gastrointestinal symptoms in autism spectrum disorders.
• Endogenous opioids and opiate antagonists in autism: brief review of empirical findings and implications for clinicians.

Serotonin

Endogenous serotonin

• Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study.
• Elevated urine levels of bufotenine in patients with autistic spectrum disorders and schizophrenia.

Pharmacotherapy

For substances, see Serotonin.

• LSD: Flashback to the 1960s: LSD in the treatment of autism.

Entacogens

• MDMA: MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults.
• MDMA: Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study.

See also

• Talk:Pharmaceutical
• Talk:Psychiatric diagnoses

External links

• Autism spectrum (Wikipedia)