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2C-T
Revision as of 10:48, 14 July 2020 by >Mydriasis(Updated effects, visual. Also grammar.)
2,5-Dimethoxy-4-methylthiophenethylamine (commonly known as 2C-T) is a psychedelic substance of the phenethylamine chemical class that produces psychedelic effects when administered.
It is a member of the 2C-x family of psychedelic phenethylamines, all of which were derived from the systematic modification of the mescaline molecule.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
2C-T It was first synthesized and studied through a collaboration between David E. Nichols and Alexander Shulgin.[1]
It is described in Shulgin's 1991 book PiHKAL ("Phenethylamines I Have Known and Loved").[2]
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has a relatively short history of human usage. It is highly advised to approach this hallucinogenic substance with the proper amount of precaution and harm reduction practices if using it.
As a result, it may contain incomplete or wrong information. You can help by expanding it.
2C-T is almost unknown on the black market and is rarely sold online.
Chemistry
Generic structure of a phenethylamine molecule
2C-T, or 2,5-dimethoxy-4-methylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through a methyl chain. 2C-T belongs to the 2C family of phenethylamines which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T is also substituted at R4 with an methyl thioether group.
The mechanism of action that produces 2C-T’s hallucinogenic and entheogenic effects has not been established in scientific literature; however, its primary psychedelic effects are more than likely a result of its efficacy at the 5-HT2A receptor as a partial agonist. This mechanism of action is shared by many other psychedelic phenethylamines and tryptamines.
However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.
Being similar in structure to 2C-T-2 and 2C-T-7, this compound may have some MAOI properties.
Subjective effects
The effects of 2C-T have been described as being less visual and more in the body.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
There are currently no anecdotal reports which describe the effects of this compound within our experience index.
Toxicity and harm potential
This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational 2C-T use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown.
Anecdotal reports suggest that there are no negative health effects attributed to trying this drug, but nothing can be completely guaranteed.
2C-T is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.
Tolerance to the effects of 2C-T are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 2C-T all psychedelics will have a reduced effect.
Dangerous interactions
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
Although only speculative, it is worth noting that if 2C-T does have MAOI effects this could indicate that 2C-T is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[3] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which promotes the release of neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:
↑Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
