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Template:DangerousInteractions/Psychedelics
- Cannabis - Cannabis has an unexpectedly strong and somewhat unpredictable synergy with the effects of psychedelics. Extreme caution is advised when using this combination as it can significantly increase the chances of a negative psychological reaction like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid over intake.
- Stimulants - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable anxiety, panic, thought loops, and paranoia. This interaction may result in an elevated risk of mania and psychosis.[citation needed]
- Lithium - Lithium is often prescribed as a treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its glutaminergic and GABAergic effects.[citation needed]
- Tramadol - Tramadol lowers the seizure threshold[1] and psychedelics may act as triggers for seizures in susceptible individuals.[citation needed]
- ↑ Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of Medical Toxicology, 5(2), 63-67. https://doi.org/10.1007/BF03161089