2C-T-7

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Serious injury or death may occur if 2C-T-7 is insufflated or combined with certain substances and medications (e.g. MAOIs or RIMAs)[1][2][3]

It is strongly discouraged to insufflate (snort), eyeball, administer non-orally, or combine this substance with certain other substances. Please see this section for more details.

Summary sheet: 2C-T-7

Template:SubstanceBox/2-C-T7

2,5-dimethoxy-4-propylthiophenethylamine (abbreviated 2C-T-7; also known as Blue Mystic and 7th Heaven among others) is a psychedelic phenethylamine of the 2C-x family. It was first synthesized by Alexander Shulgin and documented in his book PiHKAL ("Phenethylamines I Have Known and Loved")[4]. This particular substance is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which -- with the exception of mescaline -- he developed, synthesized and tested on himself. They can be found within the first book of PiHKAL, and are as follows: Mescaline, DOM, 2C-B, 2C-E, 2C-T-2 and 2C-T-7.[5]

2C-T-7 is considered by the community as a highly unpredictable dose sensitive psychedelic that has gained a reputation for its strong, potentially blinding visuals and intense body load that can manifest as fever-like delirium in extreme cases. Many reports also indicate that the physical effects are too severe for those who are not already experienced with psychedelics or suffer from pre-existing physical conditions as it is known to cause powerful nausea, body temperature disregulation, and general bodily discomfort.[citation needed]

For this reason, it is strongly recommended that one use harm reduction practices when choosing to experiment with this substance.

Chemistry

 
Generic structure of a phenethylamine molecule

2C-T-7, or 2,5-dimethoxy-4-propylthiophenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain.

2C-T-7 belongs to the 2C family of phenethylamines, which contain methoxy functional groups CH3O- attached to carbons R2 and R5 of the benzene ring. 2C-T-7 is also substituted at R4 with a propyl thioether group.

2C-T-7 is analogous to 2C-T-2; the two differ by the length of the alkane chain in their thioether functional group.[6]

Pharmacology

Further information: Serotonergic psychedelic

2C-T-7's psychedelic effects have been shown to come from its efficacy at the 5-HT2A receptor as a partial agonist.[7] However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

As the 2,5-desmethoxy derivative of 2C-T-7 has been shown to be a moderate monoamine oxidase An inhibitor, this substance is widely thought to have MAOI effects.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Uncomfortable physical side effects

Tactile effects

  • Spontaneous physical sensations - The "body high" of 2C-T-7 is intense, but in comparison to 2C-E or 2C-B, it can be considered mild though is still capable of becoming very powerful and highly physically euphoric. It is similar yet distinct from the "body high" experienced on 2C-E, 2C-B, and LSD. The sensation itself can be described as intense and will manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
  • Tactile enhancement
  • Tactile hallucinations

Cognitive effects

The head space of 2C-T-7 is described by many as one which is both insightful and relatively normal in its thought processes even at moderate to high dosages.

The total sum of these cognitive components regardless of the setting generally includes:

Visual effects

The visual geometry that is present throughout this trip can be described as more similar in appearance to that of 4-AcO-DMT or ayahuasca than that of LSD, 2C-B or 2C-I. They can be comprehensively described as structured in their organization, organic in geometric style, intricate in complexity, large, fast and smooth in motion, colorful in scheme, glossy in color, sharp in their edges and equally rounded and angular in their corners. It gives off a contradictory natural and synthetic feel with slightly more mystical and shamanic undertones in comparison to other phenethylamines. At higher dosages, they are equally likely to result in states of Level 8A visual geometry or Level 8B. There seems to be a visual geometry that is extremely similar to 2C-E and 2C-P and can be described as equal in intensity or complexity and equal in proportion to the accompanying cognitive and physical effects.

Hallucinatory states

2C-T-7 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the phenethylamine family. These effects include:

Auditory effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Potentially dangerous interactions

If 2C-T-7 does have MAOI effects as commonly speculated, this could indicate that 2C-T-7 is more likely to induce serotonin syndrome or general neurotransmitter overload (especially at high dosages) than other serotonergic psychedelics.[8] This may make it dangerous to combine it with other MAOIs, stimulants and certain substances which releases neurotransmitters such as serotonin or dopamine. These substances include but are not limited to:

Toxicity and harm potential

There have been at least three reported deaths related to 2C-T-7 use as of August 2007, mainly at insufflated doses of 30 mg or more[citation needed] or combined with stimulants such as MDMA,[citation needed] as well as a number of very uncomfortably intense effects and hospitalizations due to the insufflation of 2C-T-7.[9]

It is strongly discouraged to administer 2C-T-7 non-orally because this can cause vomiting, numerous negative side effects, or death at high doses. In Erowid's Fall 2000 2C-T-7 survey, it was reported that the insufflation of 2C-T-7 resulted in more negative side effects than oral administration.[citation needed]

It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the administration of the intended dose.

Tolerance and addiction potential

2C-T-7 is not habit-forming and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of 2C-T-7 are built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 2C-T-7 presents cross-tolerance with [[Cross-tolerance::all psychedelics]], meaning that after the consumption of 2C-T-7 all psychedelics will have a reduced effect.

  • Brazil - Possession, production and sale is illegal as it is listed on Portaria SVS/MS nº 344.[10]
  • United Kingdom - It is illegal to produce, supply, or import this drug under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[11]
  • United States - On September 20, 2002, 2C-T-7 was classified as a Schedule I substance in the United States by an emergency ruling by the DEA. On March 18, 2004, the DEA published a final rule in the Federal Register which permanently placed 2C-T-7 in Schedule I.
  • Latvia - 2C-T-7 is a Schedule I controlled substance in Latvia.[12]
  • Germany - 2C-T-7 is scheduled in Germany.
  • Australia - In Australia, 2C-T-2 and 2C-T-7 are covered by the country's analog drug laws.
  • Canada: 2C-T-7 is considered Schedule III as it is a derivative of 2,5-dimethoxyphenethylamine.[13]
  • Netherlands - The Netherlands was the first country in the world to ban 2C-T-7 after being sold in smart shops for a short period. After 2C-T-2 was first banned, 2C-T-7 quickly appeared on the market but was soon banned as well. 2C-T-7 is a list I drug of the Opium Law.
  • Sweden - The drug is Schedule I in Sweden.[14] 2C-T-7 was first classified as a health hazard under the act "Lagen om förbud mot vissa hälsofarliga varor" (translated as "the Act on the Prohibition of Certain Goods Dangerous to Health") that made it illegal to sell or possess as of April 1, 1999.
  • Switzerland: Possession, production and sale is illegal.[15]
  • China - As of October 2015 2C-T-7 is a controlled substance in China.[16]

See also

References

  1. "Third Confirmed 2C-T-7 Death". Erowid. April 10, 2001. 
  2. "A Reported 2C-T-7 Death". Erowid. July 2003. 
  3. "Second Reported 2C-T-7 Death". Erowid. April 2, 2001. 
  4. https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
  5. https://erowid.org/library/books_online/pihkal/pihkal.shtml | PiHKAL
  6. http://isomerdesign.com/PiHKAL/read.php?id=43
  7. Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats | http://link.springer.com/article/10.1007%2Fs00213-005-0009-4
  8. Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109
  9. 2C-T-7 Overdoses & Delirium | https://www.erowid.org/chemicals/2ct7/2ct7_effects.shtml#overdose
  10. http://portal.anvisa.gov.br/documents/10181/3115436/%281%29RDC_130_2016_.pdf/fc7ea407-3ff5-4fc1-bcfe-2f37504d28b7
  11. Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted
  12. Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem (2,5-Dimetoksifeniletānamīni) | http://likumi.lv/doc.php?id=121086
  13. Controlled Drugs and Substances Act (S.C. 1996, c. 19) |http://laws-lois.justice.gc.ca/eng/acts/C-38.8/page-12.html#h-28
  14. http://www.lakemedelsverket.se/upload/lvfs/LVFS_2004-3.pdf
  15. http://web.archive.org/web/20170329020935/https://www.admin.ch/opc/de/classified-compilation/20101220/index.html
  16. "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.