3-FPM

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3'-Fluorophenmetrazine or 3-FPM is a potent and short-lived stimulant drug of the phenethylamine variety, which has recently been made available by research chemical vendors.

Chemistry

3-FPM is a fluorinated derivative of phenmetrazine (Preludin). It is a stimulant drug containing a phenethylamine skeleton, in which the terminal amine is incorporated into a morpholine ring. Its parent compound, phenmetrazine, was previously used as an appetite suppressant, but has since been withdrawn from the market.

Pharmacology

3-FPM is a sympathomimetic drug which has stimulant effects when consumed. Its mechanism of action appears to be by releasing dopamine, serotonin, and norepinephrine in the central nervous system. It has a higher affinity for all three types of receptor, when compared to methylphenidate.

Subjective effects

The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely if ever occur all at once but heavier dosages will increase the chances and are more likely to induce a full range of effects.

Physical Effects

The physical effects of caffeine can be broken down into 7 components all of which progressively intensify proportional to dosage. These are described below and generally include:

• Stimulation - In terms of its effects on the physical energy levels of the user, caffeine is usually considered to be mildly to moderately energetic and stimulating in a fashion that is considerably weaker in comparison to that of traditional recreational stimulants such as substituted amphetamines, MDMA or cocaine. This encourages physical activities such as performing chores and repetitive tasks which would otherwise be boring and strenuous physical activities. The particular style of stimulation which caffeine presents can be described as forced. This means that at higher dosages, it becomes difficult or impossible to keep still as jaw clenching, involuntarily bodily shakes and vibrations become present, resulting in an extreme shaking of the entire body, unsteadiness of the hands, and a general lack of motor control.
• Increased heart rate
• Vasoconstriction
• Appetite suppression
• Temperature regulation suppression

Cognitive Effects

The cognitive effects of caffeine can be broken down into 7 components all of which progressively intensify proportional to dosage. It contains a large number of typical stimulant cognitive effects. Although negative side effects are usually mild at lower to moderate dosages, with higher amounts or extended usage they become increasingly likely to manifest themselves. This particularly holds true during the offset of the experience.

The most prominent of these cognitive effects generally include:

• Wakefulness
• Thought acceleration
• Analysis enhancement
• Focus enhancement - This component is most effective at low to moderate dosages as anything higher will usually impair concentration.
• Motivation enhancement
• Anxiety

Toxicity and harm potential

Reports suggest that metabolites of 3-FPM have a long half-life, causing residual stimulation which lingers for several hours after administration. Side effects will increase with the amount of material consumed in a session.

Tolerance and addiction potential

As with all dopaminergic drugs, there is considerable risk of addiction with repeated use.

Legal issues

UK: Currently not covered by the Misuse of Drugs Act. Legal to possess or obtain, if not intended for human consumption.

See also

• Stimulant]
• Phenethylamine
• Methylphenidate
• Ethylphenidate

References

Drugs forum