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HXE
Revision as of 23:49, 28 September 2021 by >Dextromethorphan(up to visual effects)
It may contain incorrect information, particularly with respect to dosage, duration, subjective effects, toxicity and other risks. It may also not meet PW style and grammar standards.
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.
HXE first appeared for sale on the online research chemical market in late 2020. However, it has been announced about three years prior where it has been 'hyped' for a long time but was on hold due to synthesis difficulties.[citation needed]
Chemistry
HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine
It is substituted on the cyclohexane ring with an oxygen at the 2' position and a hydroxy group at the 3 position on the phenyl ring. In contrast, MXE is substituted there with a methoxy group.
Pharmacology
Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWikicontributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
HXE's effects resemble rather the effects of MXPr, MXE, DCK than more chaotic derivatives like O-PCE or MXiPr. Compared to MXE, it has less of a warmth to it and is weaker in its euphoria and clearheadedness.
Physical effects
Stimulation or Sedation - HXE has a mild stimulating effect which promotes activities like socializing or moving. Higher doses will evidently lead to greater amounts of sedation as moving around can become difficult. However, there are some stimulating effects that persist at higher dosages as well.
Spontaneous physical sensations - The body feeling of HXE can be described as slightly warm, but also empty or rough at times.
Perfection of bodily lightness - This creates the sensation that the body is floating and has become entirely weightless. This effect is strangely stimulating and encourages physical activities at low to moderate doses by making the body feel light and effortless to move.
Motor control loss - A loss of gross and fine motor control alongside balance and coordination is prevalent within HXE and becomes especially strong at higher doses, although this compound seems to be less susceptiblw to this. This means that one should be sitting down before the onset (unless experienced) in the case of falling over and injuring oneself.
Tactile suppression - This partially to entirely suppresses one's sense of touch, creating feelings of numbness within the extremities. It is responsible for the anesthetic properties of this substance.
Nausea - High dose HXE experience can sometimes result in nausea and vomiting at the peak of the trip. For most people, this is surprisingly not as unpleasant as they would initially expect due to the accompanying detachment from the physical senses.
Double vision - This component is prevalent at moderate to heavy doses and makes reading impossible unless one closes an eye.
Pattern recognition suppression - This effect generally occurs at higher doses and makes one unable to recognize and interpret perceivable visual data.
The visual geometry found within HXE can be described as very dark and bland when compared to that of ketamine or DXM and often consists of many tiny interlocking and woven lines. It does not extend beyond level 4 and can be comprehensively described through its variations as simplistic in complexity, algorithmic in style, synthetic in feel, unstructured in organization, dimly lit in lighting, multicolored in scheme, glossy in shading, soft in edges, small in size, slow in speed, smooth in motion, equal in rounded and angular corners, immersive in-depth and consistent in intensity.
Hallucinatory states
At high doses, HXE can produce a full range of high level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used psychedelics. These effects include:
If applicable, a brief paragraph summary of the substance's cognitive effects may be included here.
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If applicable, a brief paragraph summary of the substance's auditory effects may be included here.
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If applicable, a brief paragraph summary of the substance's multisensory effects may be included here.
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If applicable, a brief paragraph summary of the substance's transpersonal effects may be included here.
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This toxicity and harm potential section is a stub.
As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.
The toxicity and long-term health effects of recreational HXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because HXE has very little history of human usage.
Warning:Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
