Methoxetamine: Difference between revisions

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==Toxicity and harm potential==

The toxicity and long-term health effects of recreational MXE use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because MXE ~~has~~ very ~~little~~ history of human usage. Anecdotal ~~evidence~~ from ~~people~~ who have tried MXE ~~within the community~~ suggests that there do not seem to be any negative health effects attributed to simply trying this ~~drug~~ at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

The toxicity and long-term health effects of recreational MXE use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]].

This is because MXE is a research chemical with a very brief history of human usage.

Anecdotal reports from those who have tried MXE suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

[https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

~~It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.~~

===Tolerance and addiction potential===

As with other NMDA receptor antagonists, the chronic use of MXE can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of ~~causing~~ psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

As with other NMDA receptor antagonists, the chronic use of MXE can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of producing psychological dependence among certain users.

When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

Tolerance to many of the effects of MXE [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). MXE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of MXE all [[dissociative]]s will have a reduced effect.

Tolerance to many of the effects of MXE [[Time to full tolerance::develops with prolonged and repeated use]].

This results in users having to administer increasingly large doses to achieve the same effects.

After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption).

MXE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of MXE all [[dissociative]]s will have a reduced effect.

===Urinary tract effects===

In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, MXE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because MXE is four times as potent as ketamine, so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, MXE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent.

This is because MXE is four times as potent as ketamine, so significantly less of drug needs to be consumed.

Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:

*'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.

@@ Line 122: / Line 122: @@
 ==Toxicity and harm potential==
 {{Further|Research chemicals#Toxicity and harm potential}}
-The toxicity and long-term health effects of recreational MXE use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]]. This is because MXE has very little history of human usage. Anecdotal evidence from people who have tried MXE within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+The toxicity and long-term health effects of recreational MXE use do not seem to have been studied in any scientific context and the [[Toxicity::exact toxic dosage is unknown]].
+This is because MXE is a research chemical with a very brief history of human usage.
+Anecdotal reports from those who have tried MXE suggests that there do not seem to be any negative health effects attributed to simply trying this substance at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
+[https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
 ===Tolerance and addiction potential===
-As with other NMDA receptor antagonists, the chronic use of MXE can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
+As with other NMDA receptor antagonists, the chronic use of MXE can be considered [[Addiction potential::moderately addictive with a high potential for abuse]] and is capable of producing psychological dependence among certain users.
+When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
-Tolerance to many of the effects of MXE [[Time to full tolerance::develops with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). MXE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of MXE all [[dissociative]]s will have a reduced effect.
+Tolerance to many of the effects of MXE [[Time to full tolerance::develops with prolonged and repeated use]].
+This results in users having to administer increasingly large doses to achieve the same effects.
+After that, it takes about [[Time to half tolerance::3 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption).
+MXE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of MXE all [[dissociative]]s will have a reduced effect.
 ===Urinary tract effects===
-In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, MXE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent. This is because MXE is four times as potent as ketamine, so significantly less of drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
+In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, MXE seems to exhibit almost identical bladder and urinary tract problems to those found within [[ketamine]], but to a lesser extent.
+This is because MXE is four times as potent as ketamine, so significantly less of drug needs to be consumed.
+Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
 *'''Urinary frequency''' - Urinary frequency is the need to empty the bladder every few minutes.