2C-E: Difference between revisions

'''2,5-Dimethoxy-4-ethylphenethylamine''' (also known as '''2C-E''', or colloquially as '''"Aquarust"'''<ref name="pubchemSYN">https://pubchem.ncbi.nlm.nih.gov/compound/2C-E#section=Synonyms</ref> and '''"Eternity"'''<ref name="pubchemSYN" />) is a potent synthetic [[psychoactive class::psychedelic]] of the [[chemical class::phenethylamine]] chemical class. It produces a highly dose-sensitive array of [[psychedelic]] effects comparable to those produced [[mescaline]] or other potent members of the [[2C-x]] family when [[Route of administration|administered]].

2C-E was first synthesized and tested for human activity by [[Alexander Shulgin]] in 1977.<ref>Shulgin, Alexander. "Pharmacology Lab Notes #2". Lafayette, CA. (1976-1980). p236 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_labbook2_searchable.pdf</ref> and was documented in his 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved"). It was rated as a member of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important [[phenethylamine]]-derived compounds, all of which except [[mescaline]] he developed and synthesized himself. They are found within the first book of [[PiHKAL]], and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], 2C-E, [[2C-T-2]] and [[2C-T-7]]. 2C-E began to appear in drug seizures around 2004<ref>"2,5-Dimethoxy-4-Ethylphenethylamine (2C-E) encountered in Ft. Pierce, Florida and Royal Oak, Michigan". Microgram Bulletin. Drug Enforcement Agency. Nov 2004. 37(11):p193-194 (Erowid.org) | https://erowid.org/library/periodicals/microgram/microgram_2004-11.pdf</ref>.

Overall, anecdotal reports tend to characterize 2C-E as a highly unpredictable, dose-sensitive psychedelic known for its strong visuals and intense "body load". The majority of reports on the effects produced by this substance indicate that it is likely overly challenging for those who are not already extensively experienced with [[hallucinogens]], particularly potent psychedelics. Therefore it is highly advised to approach this very powerful, dose-sensitive [[hallucinogenic]] substance with the proper amount of precaution, preparation, and [[harm reduction practices]] if one chooses to use it.

2C-E's [[psychedelic]] effects are believed to come from its efficacy at the [[Serotonin#The 5-HT system|5-HT_2A receptor]] as a [[Agonist#Agonists|partial agonist]]. However, the role of these interactions and how they result in the [[psychedelic]] experience continues to remain elusive.

 

*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 2C-E is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of [[MDMA]] although it is encouraged instead of forced.

*'''[[Effect::Spontaneous physical sensations]]''' - The "body high" of 2C-E is manifested as one of the most proportionally intense in comparison to almost all of the classical psychedelics. The sensation itself can be described as an intense and slightly uncomfortable energetic pins and needles sensation that constantly encompasses a person's entire body. It is usually felt over every square inch of the skin but occasionally manifests itself in the form of a continuously shifting, tingling sensation that travels up and down the body in spontaneous waves. Alongside this, many users report uncomfortable body feelings characterized by dysphoric aches and urges to shift the position of one's body and prolonged tensing of unusual combinations of muscle groups.

*'''[[Effect::Nausea]]''' -  Mild to extreme nausea is consistently reported when consumed in moderate to high doses and either passes once the tripper has vomited or gradually fades by itself as the peak sets in.

*'''[[Effect::Seizure]]''' - This is a rarely observed effect but is thought to be able to happen in those predisposed to them, especially while in physically taxing conditions such as being dehydrated, fatigued, undernourished, or overheated.{{citation needed}}

The toxicity and long-term health effects of recreational 2C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 2C-E is a [[research chemical]] with very little history of human usage. Anecdotal evidence from those within the community who have tried 2C-E suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.

2C-E is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.  

 

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

==Legality==

*[[Psychedelics]]

*[[Phenethylamines]]