Talk:Ketamine: Difference between revisions

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===Intravenous administration===

In medical settings, ketamine is usually injected [[Intravenous ~~therapy~~|intravenously]] or [[Intramuscular ~~injection~~|intramuscularly]].<ref name="lankenau">{{Cite journal |last1= Lankenau |first1= SE |last2= Sanders |first2= B |last3= Bloom |first3= JJ |last4= Hathazi |first4= D |last5= Alarcon |first5= E |last6= Tortu |first6= S |last7= Clatts |first7= MC |displayauthors= 4 |title= First injection of ketamine among young injection drug users (IDUs) in three U.S. cities |journal= [[Drug and Alcohol Dependence (journal)|Drug and Alcohol Dependence]] |volume= 87 |issue= 2–3 |pages= 183–93 |date= March 2007 |pmid= 16979848 |pmc= 1852477 |doi= 10.1016/j.drugalcdep.2006.08.015}}</ref> However, intravenous self-injection of ketamine is very dangerous. Karl Jansen warns: "If ketamine is taken by a rapid .i.v injection, it can sometimes cause the person to stop breathing for a short time (up to a minute). 2 mg/kg given i.v. as a fast injection produced a significant fall in blood oxygen lasting about 10 minutes. When given slowly (over 1.5 minutes), breathing is well maintained and may even increase slightly. However, the self-injector may then pass out before the injection is complete. Any desire to experiment with i.v. use should be resisted for as long as possible. As noted above, ketamine does not usually suppress breathing, but exceptions occur after rapid i.v. injection. This is safer when the psrson is lying down, or at least not sitting on an edge. Bathrooms are dangerous because the surface are hard and angular, there is a risk of drowing, and bleeding is more likely in warm water."<ref>Ketamine: Dreams and Realities, p276-277</ref>

In medical settings, ketamine is usually injected [[Routes_of_administration#Intravenous|intravenously]] or [[Routes_of_administration#Intramuscular|intramuscularly]].<ref name="lankenau">{{Cite journal |last1= Lankenau |first1= SE |last2= Sanders |first2= B |last3= Bloom |first3= JJ |last4= Hathazi |first4= D |last5= Alarcon |first5= E |last6= Tortu |first6= S |last7= Clatts |first7= MC |displayauthors= 4 |title= First injection of ketamine among young injection drug users (IDUs) in three U.S. cities |journal= [[Drug and Alcohol Dependence (journal)|Drug and Alcohol Dependence]] |volume= 87 |issue= 2–3 |pages= 183–93 |date= March 2007 |pmid= 16979848 |pmc= 1852477 |doi= 10.1016/j.drugalcdep.2006.08.015}}</ref> However, intravenous self-injection of ketamine is very dangerous. Karl Jansen warns: "If ketamine is taken by a rapid .i.v injection, it can sometimes cause the person to stop breathing for a short time (up to a minute). 2 mg/kg given i.v. as a fast injection produced a significant fall in blood oxygen lasting about 10 minutes. When given slowly (over 1.5 minutes), breathing is well maintained and may even increase slightly. However, the self-injector may then pass out before the injection is complete. Any desire to experiment with i.v. use should be resisted for as long as possible. As noted above, ketamine does not usually suppress breathing, but exceptions occur after rapid i.v. injection. This is safer when the psrson is lying down, or at least not sitting on an edge. Bathrooms are dangerous because the surface are hard and angular, there is a risk of drowing, and bleeding is more likely in warm water."<ref>Ketamine: Dreams and Realities, p276-277</ref>

Intravenous infusion in research labs has produced a very high correlation between blood levels and psychedelic effects.<ref>[Ketamine: Dreams and Realities, p73]</ref> The intravenous administration of 50 - 100 mg of ketamine can reproduce all of the features which have commonly been associated with [[Near-death experience|NDE]]'s. Intramuscular administration also results in NDE's, but events evolve at a slower pace and are longer lasting (Domino et al., 1965; Rumpf ,1969; Collier, 1972; Siegel,1978, 1980,1981; Stafford, 1977; Lilly, 1978; Grinspoon and Bakalar, 1981; White, 1982; Ghoniem et al., 1985; Sputz, 1989; Jansen, 1989a,b, 1990b, 1993, 1995, 1996).<ref>http://www.near-death.com/experiences/lsd03.html</ref>

The typical intravenous antidepressant dosage of ketamine used to treat depression is low and results in maximal plasma concentrations of 70 to 200 ng/mL (294–841 nM).<ref name="pmid28249076">{{cite journal | vauthors = Sanacora G, Frye MA, McDonald W, Mathew SJ, Turner MS, Schatzberg AF, Summergrad P, Nemeroff CB | title = A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | journal = JAMA Psychiatry | volume = 74 | issue = 4 | pages = 399–405 | year = 2017 | pmid = 28249076 | doi = 10.1001/jamapsychiatry.2017.0080 | url = }}</ref>

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 ===Intravenous administration===
-In medical settings, ketamine is usually injected [[Intravenous therapy|intravenously]] or [[Intramuscular injection|intramuscularly]].<ref name="lankenau">{{Cite journal |last1= Lankenau |first1= SE |last2= Sanders |first2= B |last3= Bloom |first3= JJ |last4= Hathazi |first4= D |last5= Alarcon |first5= E |last6= Tortu |first6= S |last7= Clatts |first7= MC |displayauthors= 4 |title= First injection of ketamine among young injection drug users (IDUs) in three U.S. cities |journal= [[Drug and Alcohol Dependence (journal)|Drug and Alcohol Dependence]] |volume= 87 |issue= 2–3 |pages= 183–93 |date= March 2007 |pmid= 16979848 |pmc= 1852477 |doi= 10.1016/j.drugalcdep.2006.08.015}}</ref> However, intravenous self-injection of ketamine is very dangerous. Karl Jansen warns: "If ketamine is taken by a rapid .i.v injection, it can sometimes cause the person to stop breathing for a short time (up to a minute). 2 mg/kg given i.v. as a fast injection produced a significant fall in blood oxygen lasting about 10 minutes. When given slowly (over 1.5 minutes), breathing is well maintained and may even increase slightly. However, the self-injector may then pass out before the injection is complete. Any desire to experiment with i.v. use should be resisted for as long as possible. As noted above, ketamine does not usually suppress breathing, but exceptions occur after rapid i.v. injection. This is safer when the psrson is lying down, or at least not sitting on an edge. Bathrooms are dangerous because the surface are hard and angular, there is a risk of drowing, and bleeding is more likely in warm water."<ref>Ketamine: Dreams and Realities, p276-277</ref>
+In medical settings, ketamine is usually injected [[Routes_of_administration#Intravenous|intravenously]] or [[Routes_of_administration#Intramuscular|intramuscularly]].<ref name="lankenau">{{Cite journal |last1= Lankenau |first1= SE |last2= Sanders |first2= B |last3= Bloom |first3= JJ |last4= Hathazi |first4= D |last5= Alarcon |first5= E |last6= Tortu |first6= S |last7= Clatts |first7= MC |displayauthors= 4 |title= First injection of ketamine among young injection drug users (IDUs) in three U.S. cities |journal= [[Drug and Alcohol Dependence (journal)|Drug and Alcohol Dependence]] |volume= 87 |issue= 2–3 |pages= 183–93 |date= March 2007 |pmid= 16979848 |pmc= 1852477 |doi= 10.1016/j.drugalcdep.2006.08.015}}</ref> However, intravenous self-injection of ketamine is very dangerous. Karl Jansen warns: "If ketamine is taken by a rapid .i.v injection, it can sometimes cause the person to stop breathing for a short time (up to a minute). 2 mg/kg given i.v. as a fast injection produced a significant fall in blood oxygen lasting about 10 minutes. When given slowly (over 1.5 minutes), breathing is well maintained and may even increase slightly. However, the self-injector may then pass out before the injection is complete. Any desire to experiment with i.v. use should be resisted for as long as possible. As noted above, ketamine does not usually suppress breathing, but exceptions occur after rapid i.v. injection. This is safer when the psrson is lying down, or at least not sitting on an edge. Bathrooms are dangerous because the surface are hard and angular, there is a risk of drowing, and bleeding is more likely in warm water."<ref>Ketamine: Dreams and Realities, p276-277</ref>
 Intravenous infusion in research labs has produced a very high correlation between blood levels and psychedelic effects.<ref>[Ketamine: Dreams and Realities, p73]</ref> The intravenous administration of 50 - 100 mg of ketamine can reproduce all of the features which have commonly been associated with [[Near-death experience|NDE]]'s. Intramuscular administration also results in NDE's, but events evolve at a slower pace and are longer lasting (Domino et al., 1965; Rumpf ,1969; Collier, 1972; Siegel,1978, 1980,1981; Stafford, 1977; Lilly, 1978; Grinspoon and Bakalar, 1981; White, 1982; Ghoniem et al., 1985; Sputz, 1989; Jansen, 1989a,b, 1990b, 1993, 1995, 1996).<ref>http://www.near-death.com/experiences/lsd03.html</ref>
 The typical intravenous antidepressant dosage of ketamine used to treat depression is low and results in maximal plasma concentrations of 70 to 200&nbsp;ng/mL (294–841&nbsp;nM).<ref name="pmid28249076">{{cite journal | vauthors = Sanacora G, Frye MA, McDonald W, Mathew SJ, Turner MS, Schatzberg AF, Summergrad P, Nemeroff CB | title = A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | journal = JAMA Psychiatry | volume = 74 | issue = 4 | pages = 399–405 | year = 2017 | pmid = 28249076 | doi = 10.1001/jamapsychiatry.2017.0080 | url = }}</ref>