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Thienodiazepines: Difference between revisions
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[[File:Substituted_thienodiazepine.svg|270px|thumbnail|right|The general structure of Thienodiazepines.]] | [[File:Substituted_thienodiazepine.svg|270px|thumbnail|right|The general structure of Thienodiazepines.]] | ||
A '''thienodiazepine''' is a heterocyclic compound containing a diazepine ring fused to a thiophene ring. The thienodiazepine ring structure forms the central core of several pharmaceutical drugs. Since thienodiazepines interact with the [[benzodiazepine]] receptor site, they typically have similar effects as benzodiazepines and can be considered as essentially identical. | A '''thienodiazepine''' is a heterocyclic compound containing a diazepine ring fused to a thiophene ring. The thienodiazepine ring structure forms the central core of several pharmaceutical drugs. Since thienodiazepines interact with the [[benzodiazepine]] receptor site, they typically have similar effects as benzodiazepines and can be considered as essentially identical. | ||
Similar to [[benzodiazepines]], [[Thienodiazepine#Discontinuation|the sudden discontinuation of thienodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref> | Similar to [[benzodiazepines]], [[Thienodiazepine#Discontinuation|the sudden discontinuation of thienodiazepines]] can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death. It is highly recommended to [[taper]] one's dose by gradually lowering the amount taken each day for a prolonged period of time instead of stopping abruptly.<ref>Canadian Guideline for Safe and Effective Use of Opioids for Chronic Non-Cancer Pain - Appendix B-6: Benzodiazepine Tapering | http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html</ref> | ||
==Examples== | |||
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<h3 class="panel-header">[[Thienzodiazepines]]</h3> | |||
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* [[Deschloroetizolam]] | |||
* [[Etizolam]] | |||
* [[Metizolam]] | |||
* [[Brotizolam]] | |||
* [[Bentazepam]] | |||
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==Subjective effects== | ==Subjective effects== | ||
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==Preparation methods== | ==Preparation methods== | ||
*'''[[Volumetric liquid dosing]]''' - If one's thienodiazepines are in powder form, they are unlikely to weigh out accurately without the most expensive of scales due to their extreme potency. To avoid this, one can dissolve the thienodiazepine volumetrically into a solution so as to dose it accurately based upon the instructions described in [[Volumetric liquid dosing|this tutorial]]. | *'''[[Volumetric liquid dosing]]''' - If one's thienodiazepines are in powder form, they are unlikely to weigh out accurately without the most expensive of scales due to their extreme potency. To avoid this, one can dissolve the thienodiazepine volumetrically into a solution so as to dose it accurately based upon the instructions described in [[Volumetric liquid dosing|this tutorial]]. | ||