Talk:Antidepressant: Difference between revisions

Line 2:

==Types of antidepressants==

===Selective serotonin reuptake inhibitors ([[SSRIs]])===

===Serotonergics===

:Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is ~~because~~ . SSRIs are the most commonly prescribed ~~anti depressant~~, and the most commonly prescribed anxiolytic for children.

====Serotonin reuptake inhibitors====

===Selective serotonin reuptake enhancers (SSREs)===

[[Dextromethorphan]]<ref>http://www.sciencedirect.com/science/article/pii/S0306987711000545</ref>

===Serotonin-norepinephrine reuptake inhibitor (SNRIs)===

Because dextromethorphan can show similar antidepressant effects to ketamine in low doses (compared to common recreational doses), it is possible that dextromethorphan could be a possible treatment for treatment resistant and severe depression. Many users of dextromethorphan claim that they do not feel any depression within a week of using dextromethorphan.{{citation needed}} It has a very similar mechanism of action to SSRIs. It is also useful for anxiety.

===Serotonin modulators and stimulators (SMSes)===

====Selective serotonin reuptake inhibitors ([[SSRIs]])====

===Serotonin antagonists and reuptake inhibitors (SARIs)===

:Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is that the serotonin hypothesis, one of the most commonly accepted theories for depression, states that low serotonin in the brain causes depression. SSRIs are the most commonly prescribed antidepressant, and the most commonly prescribed anxiolytic for children. They are also the first-line treatment for panic disorder, not benzodiazepines like lorazepam and alprazolam.

====Selective serotonin reuptake enhancers (SSREs)====

====Serotonin-norepinephrine reuptake inhibitor (SNRIs)====

====Serotonin modulators and stimulators (SMSes)====

====Serotonin antagonists and reuptake inhibitors (SARIs)====

====Serotonin releasing agents (SRAs)====

These agents work by directly increasing the amount of serotonin in the brain. Substances such as [[cocaine]] and [[MDMA]] can do this, but both are addictive and tolerance quickly builds to each. Additionally, the MDMA "comedown" can produce weeks to months of a low mood and motivation if the user "rolls" (doses) frequently and suddenly stops.

===Norepinephrine reuptake inhibitors (NRIs)===

:NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref>

Line 21:

Line 27:

===[[Ketamine]]===

In clinical studies, ketamine has proven to be an extremely effective and fast acting antidepressant at low doses (compared to common recreational doses).<ref>https://www.nimh.nih.gov/about/strategic-planning-reports/highlights/highlight-ketamine-a-new-and-faster-path-to-treating-depression.shtml</ref> It has become increasingly common for doctors to prescribe ketamine for treatment-resistant and severe depression.

~~===[[MDMA]]===~~

===[[LSD]]===

~~===[[Dextromethorphan]]<ref>http://www.sciencedirect.com/science/article/pii/S0306987711000545</ref>===~~

Because dextromethorphan can show similar anti-depressant effects to ketamine in low doses (compared to common recreational doses), it is possible that dextromethorphan could be a possible treatment for treatment resistant and severe depression. Many users of dextromethorphan claim that they do not feel any depression within a week of using dextromethorphan.

==References==

[[Category:Articles in talk page]]

@@ Line 2: / Line 2: @@
 ==Types of antidepressants==
-===Selective serotonin reuptake inhibitors ([[SSRIs]])===
+===Serotonergics===
-:Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is because . SSRIs are the most commonly prescribed anti depressant, and the most commonly prescribed anxiolytic for children.
+====Serotonin reuptake inhibitors====
-===Selective serotonin reuptake enhancers (SSREs)===
+[[Dextromethorphan]]<ref>http://www.sciencedirect.com/science/article/pii/S0306987711000545</ref>
-===Serotonin-norepinephrine reuptake inhibitor (SNRIs)===
+Because dextromethorphan can show similar antidepressant effects to ketamine in low doses (compared to common recreational doses), it is possible that dextromethorphan could be a possible treatment for treatment resistant and severe depression. Many users of dextromethorphan claim that they do not feel any depression within a week of using dextromethorphan.{{citation needed}} It has a very similar mechanism of action to SSRIs. It is also useful for anxiety.
-===Serotonin modulators and stimulators (SMSes)===
+====Selective serotonin reuptake inhibitors ([[SSRIs]])====
-===Serotonin antagonists and reuptake inhibitors (SARIs)===
+:Selective serotonin reuptake inhibitors are believed to increase the level of extracellular [[serotonin]], therefore allowing more serotonin to be in the brain. The reason SSRIs are used for depression is that the serotonin hypothesis, one of the most commonly accepted theories for depression, states that low serotonin in the brain causes depression. SSRIs are the most commonly prescribed antidepressant, and the most commonly prescribed anxiolytic for children. They are also the first-line treatment for panic disorder, not benzodiazepines like lorazepam and alprazolam.
+====Selective serotonin reuptake enhancers (SSREs)====
+====Serotonin-norepinephrine reuptake inhibitor (SNRIs)====
+====Serotonin modulators and stimulators (SMSes)====
+====Serotonin antagonists and reuptake inhibitors (SARIs)====
+====Serotonin releasing agents (SRAs)====
+These agents work by directly increasing the amount of serotonin in the brain. Substances such as [[cocaine]] and [[MDMA]] can do this, but both are addictive and tolerance quickly builds to each. Additionally, the MDMA "comedown" can produce weeks to months of a low mood and motivation if the user "rolls" (doses) frequently and suddenly stops.
 ===Norepinephrine reuptake inhibitors (NRIs)===
 :NRIs are believed to increase the level of extracellular [[norepinephrine]], therefore allowing more of it to be in the brain. Controversy has been sparked over the effectiveness of reboxetine, an NRI sold as Trintellix. <ref>"Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis." Multiple authors (2009) https://www.researchgate.net/profile/Andrea_Cipriani/publication/23967068_Comparative_efficacy_and_acceptability_of_12_new-generation_antidepressants_A_multiple-treatments_meta-analysis/links/00b7d5278b5bed4c17000000.pdf</ref>
@@ Line 21: / Line 27: @@
 ===[[Ketamine]]===
 In clinical studies, ketamine has proven to be an extremely effective and fast acting antidepressant at low doses (compared to common recreational doses).<ref>https://www.nimh.nih.gov/about/strategic-planning-reports/highlights/highlight-ketamine-a-new-and-faster-path-to-treating-depression.shtml</ref> It has become increasingly common for doctors to prescribe ketamine for treatment-resistant and severe depression.
-===[[MDMA]]===
 ===[[LSD]]===
-===[[Dextromethorphan]]<ref>http://www.sciencedirect.com/science/article/pii/S0306987711000545</ref>===
+{{citation needed}}
-Because dextromethorphan can show similar anti-depressant effects to ketamine in low doses (compared to common recreational doses), it is possible that dextromethorphan could be a possible treatment for treatment resistant and severe depression. Many users of dextromethorphan claim that they do not feel any depression within a week of using dextromethorphan.
 ==References==
 [[Category:Articles in talk page]]