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Benzodiazepines: Difference between revisions
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==History== | ==History== | ||
[[File:Chlordiazepoxide | [[File:Chlordiazepoxide.svg|thumb|250px|right|alt=Chemical structure diagram of a benzene ring fused to a diazepine ring. Cl is attached to the benzene; N, H, CH3, and O are attached to the diazepine.|The molecular structure of chlordiazepoxide, the first benzodiazepine. It was marketed by Hoffmann–La Roche from 1960 branded as ''Librium''.]] | ||
The first benzodiazepine, chlordiazepoxide (''Librium''), was synthesized in 1955 by Leo Sternbach while working at Hoffmann–La Roche on the development of tranquilizers. The pharmacological properties of the compounds prepared initially were disappointing, and Sternbach abandoned the project. | The first benzodiazepine, chlordiazepoxide (''Librium''), was synthesized in 1955 by Leo Sternbach while working at Hoffmann–La Roche on the development of tranquilizers. The pharmacological properties of the compounds prepared initially were disappointing, and Sternbach abandoned the project. | ||