Pethidine: Difference between revisions

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~~{{DangerousInteractions/Dissociatives}}~~

*'''[[Psychedelics]]''' - Pethidine is known to lower seizure threshold{{citation needed}} and psychedelics also cause occasional seizures.{{citation needed}}

*'''[[Stimulants]]''' - It is dangerous to combine pethidine, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of pethidine, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of pethidine will be significantly increased, leading to intensified [[disinhibition]] as well as [[pethidine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only taking a certain amount of pethidine.

*'''[[~~Psychedelic~~]]s''' - Pethidine is ~~well~~ known to lower seizure threshold and psychedelics also cause occasional seizures.

====[[Serotonin syndrome]] risk====

Pethidine is known to ~~cause~~ serotonin syndrome ~~at a significantly higher rate~~ than other serotonergic opioids such as [[tramadol]].

Pethidine is known to have a significantly increased chance of causing serotonin syndrome than other serotonergic opioids such as [[tramadol]].{{citation needed}}

@@ Line 64: / Line 64: @@
 {{DangerousInteractions/Intro}}
 {{DangerousInteractions/Depressants}}
-{{DangerousInteractions/Dissociatives}}
+*'''[[Psychedelics]]''' - Pethidine is known to lower seizure threshold{{citation needed}} and psychedelics also cause occasional seizures.{{citation needed}}
-*'''[[Stimulants]]''' -  It is dangerous to combine pethidine, a [[depressant]], with [[stimulant]]s due to the risk of excessive intoxication. Stimulants decrease the [[sedation|sedative]] effect of pethidine, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of pethidine will be significantly increased, leading to intensified [[disinhibition]] as well as [[pethidine#Subjective effects|other effects]]. If combined, one should strictly limit themselves to only taking a certain amount of pethidine.
-*'''[[Psychedelic]]s''' - Pethidine is well known to lower seizure threshold and psychedelics also cause occasional seizures.
 ====[[Serotonin syndrome]] risk====
-Pethidine is known to cause serotonin syndrome at a significantly higher rate than other serotonergic opioids such as [[tramadol]].
+Pethidine is known to have a significantly increased chance of causing serotonin syndrome than other serotonergic opioids such as [[tramadol]].{{citation needed}}
 {{DangerousInteractions/SerotoninSyndrome}}