Talk:3-HO-PCE: Difference between revisions

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:::::[[User:Clarity|@Clarity]] are EC and ED really the only ways to go? I would love to start a chem testing business, I just can't get thru the red tape! When I read my countries laws about testing and certification and other concerns, I was appalled by all the bureaucracy and restrictions, so I backed out. Did you know that, if you detect a scheduled chemical in my country, you can't report it's purity? you can only report it was detected, and the total mass of the sample, and then LEO takes that and does their own nonsense calculations on doses? so for instance, if you put 100mu of LSD in 100ml of water, they would say that it is many more doses than it really is. as a testing facility, you cannot report concentration or purity. how crazy is that? I digress... Yes, I know of ec and ed. I guess I will send off samples! ugh... I wish I lived in Wales (not really)[[User:Lunch-clunge|Lunch-clunge]] ([[User talk:Lunch-clunge|talk]]) 17:37, 28 April 2017 (PDT)

:[[User:Lunch-clunge|@Lunchclunge]] Hello Lunch. Regarding your speculations: I second you on µ-opiod activity. ~~This seems to be~~ exclusive to 3-HO-PCP ~~in fact~~. I do however strongly believe in the risk of mania and/or psychosis similar to other PCP/PCE analogs. ~~It is~~ also ~~possible that it shares~~ Sigma receptor activity. 3-HO-PCE combined with a D2 receptor partial agonist ~~has~~ prolonged ~~the~~ onset ~~with~~ 2-3 hours effectively "removing" a "first phase" of effects (stimulant euphoria, stimulant alertness) while leaving a "second phase" with typical dissociative and dissociative psychedelic/hallucinogenic effects intact. PCP (and Ketamine) is a D2 receptor agonist (https://www.ncbi.nlm.nih.gov/pubmed/19391150). This was an interesting observation to me ~~and~~ could hint about a peculiar metabolism with different active metabolites... Metabolism of ACHs is complex and nothing I understand well and so speculating about the metabolism involved in a new ACH like 3-HO-PCE is way above me =). Kind regards [[User:Vlk|vLK]]

:[[User:Lunch-clunge|@Lunchclunge]] Hello Lunch. Regarding your speculations: I second you on µ-opiod activity. I believe this is exclusive to 3-HO-PCP. I do however strongly believe in the risk of mania and/or psychosis similar to other PCP/PCE analogs. 3-HO-PCE may also share some of their Sigma receptor activity. When 3-HO-PCE was combined with a D2 receptor partial agonist there was a much prolonged onset (2-3 hours), effectively "removing" a "first phase" of effects (stimulant euphoria, stimulant alertness) while leaving a "second phase" with typical dissociative and dissociative psychedelic/hallucinogenic effects intact. PCP (and Ketamine) is a D2 receptor agonist (https://www.ncbi.nlm.nih.gov/pubmed/19391150). This was an interesting observation and reminded me about how Buprenorphine treats opioid addiction (MOR partial agonist, high affinity, effectievly blocking the effects of other MOR agonists). It could hint about a peculiar metabolism with different active metabolites ("first and second phase")... Metabolism of ACHs is complex and nothing I understand well and so speculating about the metabolism involved in a new ACH like 3-HO-PCE is way above me =). Kind regards [[User:Vlk|vLK]]

Revision as of 11:31, 24 August 2017 view source >Vlk Re: 3hopce pharma. ← Older edit		Latest revision as of 11:47, 24 August 2017 view source >Vlk m Clarifying myself
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	:::::[[User:Clarity\|@Clarity]] are EC and ED really the only ways to go? I would love to start a chem testing business, I just can't get thru the red tape! When I read my countries laws about testing and certification and other concerns, I was appalled by all the bureaucracy and restrictions, so I backed out. Did you know that, if you detect a scheduled chemical in my country, you can't report it's purity? you can only report it was detected, and the total mass of the sample, and then LEO takes that and does their own nonsense calculations on doses? so for instance, if you put 100mu of LSD in 100ml of water, they would say that it is many more doses than it really is. as a testing facility, you cannot report concentration or purity. how crazy is that? I digress... Yes, I know of ec and ed. I guess I will send off samples! ugh... I wish I lived in Wales (not really)[[User:Lunch-clunge\|Lunch-clunge]] ([[User talk:Lunch-clunge\|talk]]) 17:37, 28 April 2017 (PDT)		:::::[[User:Clarity\|@Clarity]] are EC and ED really the only ways to go? I would love to start a chem testing business, I just can't get thru the red tape! When I read my countries laws about testing and certification and other concerns, I was appalled by all the bureaucracy and restrictions, so I backed out. Did you know that, if you detect a scheduled chemical in my country, you can't report it's purity? you can only report it was detected, and the total mass of the sample, and then LEO takes that and does their own nonsense calculations on doses? so for instance, if you put 100mu of LSD in 100ml of water, they would say that it is many more doses than it really is. as a testing facility, you cannot report concentration or purity. how crazy is that? I digress... Yes, I know of ec and ed. I guess I will send off samples! ugh... I wish I lived in Wales (not really)[[User:Lunch-clunge\|Lunch-clunge]] ([[User talk:Lunch-clunge\|talk]]) 17:37, 28 April 2017 (PDT)

	:[[User:Lunch-clunge\|@Lunchclunge]] Hello Lunch. Regarding your speculations: I second you on µ-opiod activity. ~~This seems to be~~ exclusive to 3-HO-PCP ~~in fact~~. I do however strongly believe in the risk of mania and/or psychosis similar to other PCP/PCE analogs. ~~It is~~ also ~~possible that it shares~~ Sigma receptor activity. 3-HO-PCE combined with a D2 receptor partial agonist ~~has~~ prolonged ~~the~~ onset ~~with~~ 2-3 hours effectively "removing" a "first phase" of effects (stimulant euphoria, stimulant alertness) while leaving a "second phase" with typical dissociative and dissociative psychedelic/hallucinogenic effects intact. PCP (and Ketamine) is a D2 receptor agonist (https://www.ncbi.nlm.nih.gov/pubmed/19391150). This was an interesting observation to me ~~and~~ could hint about a peculiar metabolism with different active metabolites... Metabolism of ACHs is complex and nothing I understand well and so speculating about the metabolism involved in a new ACH like 3-HO-PCE is way above me =). Kind regards [[User:Vlk\|vLK]]		:[[User:Lunch-clunge\|@Lunchclunge]] Hello Lunch. Regarding your speculations: I second you on µ-opiod activity. I believe this is exclusive to 3-HO-PCP. I do however strongly believe in the risk of mania and/or psychosis similar to other PCP/PCE analogs. 3-HO-PCE may also share some of their Sigma receptor activity. When 3-HO-PCE was combined with a D2 receptor partial agonist there was a much prolonged onset (2-3 hours), effectively "removing" a "first phase" of effects (stimulant euphoria, stimulant alertness) while leaving a "second phase" with typical dissociative and dissociative psychedelic/hallucinogenic effects intact. PCP (and Ketamine) is a D2 receptor agonist (https://www.ncbi.nlm.nih.gov/pubmed/19391150). This was an interesting observation and reminded me about how Buprenorphine treats opioid addiction (MOR partial agonist, high affinity, effectievly blocking the effects of other MOR agonists). It could hint about a peculiar metabolism with different active metabolites ("first and second phase")... Metabolism of ACHs is complex and nothing I understand well and so speculating about the metabolism involved in a new ACH like 3-HO-PCE is way above me =). Kind regards [[User:Vlk\|vLK]]