25x-NBOMe: Difference between revisions

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{{headerpanel|{{Warning/25x-NBOMe}}}}

[[File:25x-NBOMe.png|301px|thumbnail|The general structure for a 25x-NBOMe compound]]

'''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.

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==Toxicity and harm potential==

~~The~~ 25x-NBOMe ~~chemicals, as with many other serotonergic psychedelics, should~~ not ~~be taken in combination with SSRIs (selective~~ [[~~serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants~~]]. ~~This helps~~ to ~~avoid [[serotonin syndrome]], a potentially life~~-~~threatening condition in which an abundance of serotonin builds up in the body, which in some cases can be fatal~~.

===Tolerance and addiction potential===

Members of the 25x-NBOMe series are not [[Addiction potential::not habit-forming]] and the desire to use them can actually decrease with use. They are thought to be mostly self-regulating.

==~~Legality~~==

Tolerance to the effects of 25x-NBOMe is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25x-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.

===Dangerous interactions===

*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}

*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}

*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}

====[[Serotonin syndrome]] risk====

==Legal status==

*'''United States:''' In the US, some of the 25x-NBOMe chemicals are listed as Schedule I substances and others may be considered analogues under the Federal Analog Act.{{citation needed}}

*'''United Kingdom''' - The majority of synthesised 25x-NBOMe substances are Class A drugs in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.<ref>United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made</ref> Any compounds not covered by the clause are illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>

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*[[2C-x]]

*[[DOx]]

==Literature==

*Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H., & Kristensen, J. L. (2014). Synthesis and structure–activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chemical Neuroscience, 5(3), 243-249. https://doi.org/10.1021/cn400216u

@@ Line 1: / Line 1: @@
-{{Warning/25x-NBOMe}}
+{{headerpanel|{{Warning/25x-NBOMe}}}}
 [[File:25x-NBOMe.png|301px|thumbnail|The general structure for a 25x-NBOMe compound]]
 '''25x-NBOMe''' is the general form of the NBOMe series of psychedelic [[phenethylamines]]. The series had nearly no history of human use before 2010 when some of the first compounds became available for purchase from online [[research chemical]] vendors.
@@ Line 35: / Line 35: @@
 ==Toxicity and harm potential==
-The 25x-NBOMe chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective [[serotonin]] [[reuptake inhibitor]]s) or [[tricyclic antidepressants]]. This helps to avoid [[serotonin syndrome]], a potentially life-threatening condition in which an abundance of serotonin builds up in the body, which in some cases can be fatal.
+{{toxicity}}
+===Tolerance and addiction potential===
+Members of the 25x-NBOMe series are not [[Addiction potential::not habit-forming]] and the desire to use them can actually decrease with use. They are thought to be mostly self-regulating.
-==Legality==
+Tolerance to the effects of 25x-NBOMe is built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::1 week]] for the tolerance to be reduced to half and [[Time to zero tolerance::2 weeks]] to be back at baseline (in the absence of further consumption). 25x-NBOMe presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 25I-NBOMe all psychedelics will have a reduced effect.
+===Dangerous interactions===
+{{DangerousInteractions/Intro}}
+*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}
+*'''[[Stimulants]]''' - Stimulants affect many parts of the brain. Combined with psychedelics, stimulation can turn into uncontrollable [[anxiety]], [[Panic attacks|panic]], [[thought loops]] and [[paranoia]]. This interaction may cause elevated risk of psychosis.{{citation needed}}
+*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}}
+====[[Serotonin syndrome]] risk====
+{{DangerousInteractions/SerotoninSyndrome}}
+==Legal status==
+{{legalStub}}
 *'''United States:''' In the US, some of the 25x-NBOMe chemicals are listed as Schedule I substances and others may be considered analogues under the Federal Analog Act.{{citation needed}}
 *'''United Kingdom''' - The majority of synthesised 25x-NBOMe substances are Class A drugs in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.<ref>United Kingdom. (2014). Misuse of Drugs Act 1971 (S.I. 2014/1106). London: The Stationery Office Limited. Retrieved July 5, 2017, from http://www.legislation.gov.uk/uksi/2014/1106/made</ref> Any compounds not covered by the clause are illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26th, 2016.<ref>Psychoactive Substances Act 2016 (Legislation.gov.uk) | http://www.legislation.gov.uk/ukpga/2016/2/contents/enacted</ref>
@@ Line 48: / Line 63: @@
 *[[2C-x]]
 *[[DOx]]
 ==Literature==
 *Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H., & Kristensen, J. L. (2014). Synthesis and structure–activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chemical Neuroscience, 5(3), 243-249. https://doi.org/10.1021/cn400216u