3C-E: Difference between revisions

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'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::~~amphetamine|substituted~~ amphetamine]] chemical class. Although ~~it's~~ name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]

'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine]] chemical class. Although its name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]

Today, 3C-E is used as a [[recreational drug use|recreational drug]] and an [[entheogen]], probably non-existent on the streets and rarely found at gray area [[research chemical]] vendors. Very little is known about its effects besides its strong body high and weak visuals. It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.

It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.

~~Many reports also suggest that this substance may be overly difficult to use safely~~ for ~~those who are not already very experienced with~~ [[~~hallucinogens~~]]~~. Therefore it is highly advised to approach this substance with the proper amount of precaution~~ and [[~~harm reduction practices~~]] ~~if choosing to use it~~.

Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.

==Chemistry==

3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the [[substituted amphetamine]] class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. 3C-E contains methoxy functional groups OCH3 attached to carbons R3 and R5 and an ethoxy chain OCH2CH3 attached to carbon R4 of the phenyl ring. 3C-E is the amphetamine ~~analogue~~ of [[escaline]].

3C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the [[substituted amphetamine]] class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH2) group through an ethyl chain and a methyl group bound to the alpha carbon Rα. 3C-E contains methoxy functional groups OCH3 attached to carbons R3 and R5 and an ethoxy chain OCH2CH3 attached to carbon R4 of the phenyl ring.

3C-E is the amphetamine analog of [[escaline]].

==Pharmacology==

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*'''[[Effect::Pupil dilation]]'''

*'''[[Effect::Salivation]]'''

*'''[[Effect::Seizure]]''' - This is a ~~rarely observed~~ effect but ~~is known to happen~~ in those who are ~~presumably~~ predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}

*'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}

}}

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*'''[[Effect::Brightness alteration]]'''

*'''[[Effect::Diffraction]]'''

====[[Effect::Geometry]]====

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==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 3C-E is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the ~~psychonaut~~ community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying ~~the drug~~ by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 3C-E is a [[research chemical]] with very little history of human usage.

Anecdotal evidence from people within the community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

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===Dangerous interactions===

Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

*'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}

@@ Line 4: / Line 4: @@
 {{SubstanceBox/3C-E}}
-'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine|substituted amphetamine]] chemical class. Although it's name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]
+'''3,5-Dimethoxy-4-ethoxyamphetamine''' (commonly known as '''3C-E''' or '''3C-Escaline''') is a synthetic [[psychoactive class::psychedelic]] compound of the [[chemical class::amphetamine]] chemical class. Although its name suggests it may be related to the [[2C-x]] family, this is not the case since it is the 3-Carbon analog of [[escaline]]
-Today, 3C-E is used as a [[recreational drug use|recreational drug]] and an [[entheogen]], probably non-existent on the streets and rarely found at gray area [[research chemical]] vendors. Very little is known about its effects besides its strong body high and weak visuals. It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.
+It was presumably first synthesized by [[Alexander Shulgin]] and published in his book [[PiHKAL]] in 1991.
-Many reports also suggest that this substance may be overly difficult to use safely for those who are not already very experienced with [[hallucinogens]]. Therefore it is highly advised to approach this substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it.
+Today, 3C-E is used for [[recreational drug use|recreational]] and research purposes, and exclusively distributed as a gray area [[research chemical]] by online vendors. Very little is known about its effects besides its strong body high and weak visuals.
 ==Chemistry==
-C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the [[substituted amphetamine]] class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and a methyl group bound to the alpha carbon R<sub>α</sub>. 3C-E contains methoxy functional groups OCH<sub>3</sub> attached to carbons R<sub>3</sub> and R<sub>5</sub> and an ethoxy chain OCH<sub>2</sub>CH<sub>3</sub> attached to carbon R<sub>4</sub> of the phenyl ring. 3C-E is the amphetamine analogue of [[escaline]].
+C-E or 3,5-Dimethoxy-4-ethoxyamphetamine, is a molecule of the [[substituted amphetamine]] class. Amphetamines are substituted phenethylamines containing a phenyl ring bound to an amino (NH<sub>2</sub>) group through an ethyl chain and a methyl group bound to the alpha carbon R<sub>α</sub>. 3C-E contains methoxy functional groups OCH<sub>3</sub> attached to carbons R<sub>3</sub> and R<sub>5</sub> and an ethoxy chain OCH<sub>2</sub>CH<sub>3</sub> attached to carbon R<sub>4</sub> of the phenyl ring.
+C-E is the amphetamine analog of [[escaline]].
 ==Pharmacology==
@@ Line 47: / Line 49: @@
 *'''[[Effect::Pupil dilation]]'''
 *'''[[Effect::Salivation]]'''
-*'''[[Effect::Seizure]]''' - This is a rarely observed effect but is known to happen in those who are presumably predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}
+*'''[[Effect::Seizure]]''' - This is likely a rare effect but may occur in those who are predisposed to them, especially while in physically taxing conditions such as being dehydrated, undernourished, overheated, or fatigued.{{citation needed}}
 }}
@@ Line 67: / Line 69: @@
 *'''[[Effect::Brightness alteration]]'''
 *'''[[Effect::Diffraction]]'''
 ====[[Effect::Geometry]]====
@@ Line 131: / Line 132: @@
 ==Toxicity and harm potential==
+{{toxicity}}
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
-The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 3C-E is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+The toxicity and long-term health effects of recreational 3C-E use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 3C-E is a [[research chemical]] with very little history of human usage.
+Anecdotal evidence from people within the community who have tried 3C-E suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
 It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
@@ Line 142: / Line 146: @@
 ===Dangerous interactions===
-{{DangerousInteractions}}
+{{DangerousInteractions/Intro}}
-Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
 *'''[[Tramadol]]''' - Tramadol lowers the seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.{{citation needed}}