4-HO-EPT: Difference between revisions

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'''4-HO-~~EPT~~''' (also known as ''' 4-~~hydroxy~~-~~N-ethyl-N-propyltryptamine~~''') is a ~~new and obscure [[hallucinogen]]ic~~ [[psychoactive class::psychedelic]] ~~drug~~ of the [[chemical class::tryptamine]] class.

''' 4-Hydroxy-N-ethyl-N-propyltryptamine''' (also known as '''4-HO-EPT''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is structurally related to [[psilocin]] ('''4-HO-DMT'''), the active component in [[psilocybin mushrooms]], and produces similar effects.

It ~~is either used recreationally or as [[entheogen]]ic compound and is typically acquired through the~~ use of online [[research chemical]] ~~vendors on which it first appeared as recently as mid~~ 2016.

Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-EPT. It has no history of human use before being sold online as a [[research chemical]] in 2016.{{citation needed}} It remains obscure and is either used recreationally or for research purposes.

==Chemistry==

4-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a ~~bicylic~~ indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine RN of its tryptamine backbone ([[EPT]]).

4-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R3 to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R4 of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine RN of its tryptamine backbone ([[EPT]]).

==Pharmacology==

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~~===Physical~~ effects~~===~~

{{effects/base

*'''[[Effect::Spontaneous ~~tactile~~ sensations]]'''

|{{effects/physical|

*'''[[Effect::Spontaneous physical sensations]]'''

*'''[[Effect::Increased heart rate]]'''

*'''[[Effect::Nausea]]'''

*'''[[Effect::Pupil dilation]]'''

~~===Cognitive effects===~~

}}

*'''[[Effect::Conceptual thinking]]'''

{{effects/visual|

*'''[[Effect::Cognitive euphoria]]'''

*'''[[Effect::Delusions]]'''

*'''[[Effect::Emotionality enhancement]]'''

*'''[[Effect::Immersion enhancement]]'''

*'''[[Effect::Increased music appreciation]]'''

*'''[[Effect::Memory suppression]]'''

**'''[[Effect::Ego death]]'''

*'''[[Effect::Novelty enhancement]]'''

*'''[[Effect::Personal bias suppression]]'''

*'''[[Effect::Thought loops]]'''

*'''[[Effect::Time distortion]]'''

*'''[[Effect::Unity and interconnectedness]]'''

~~===Visual~~ effects~~===~~

====Enhancements====

*'''[[Effect::Colour enhancement]]'''

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*'''[[Effect::Diffraction]]'''

===[[Effect::Geometry]]===

====[[Effect::Geometry]]====

====Hallucinatory states====

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*'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')

~~===Auditory~~ effects~~===~~

}}

|{{effects/cognitive|

*'''[[Effect::Conceptual thinking]]'''

*'''[[Effect::Cognitive euphoria]]'''

*'''[[Effect::Delusions]]'''

*'''[[Effect::Emotionality enhancement]]'''

*'''[[Effect::Immersion enhancement]]'''

*'''[[Effect::Increased music appreciation]]'''

*'''[[Effect::Memory suppression]]'''

**'''[[Effect::Ego death]]'''

*'''[[Effect::Novelty enhancement]]'''

*'''[[Effect::Personal bias suppression]]'''

*'''[[Effect::Thought loops]]'''

*'''[[Effect::Time distortion]]'''

}}

{{effects/auditory|

*'''[[Effect::Auditory enhancement|Enhancements]]'''

*'''[[Effect::Auditory distortion|Distortions]]'''

*'''[[Effect::Auditory hallucinations|Hallucinations]]'''

}}

{{effects/transpersonal|

*'''[[Effect::Unity and interconnectedness]]'''

}}

==Toxicity and harm potential==

{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}

The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-EPT is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the ~~psychonaut~~ community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the ~~drug~~ by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-EPT is a [[research chemical]] with very little history of human usage.

Anecdotal evidence from people within the community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this ~~drug~~.

It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.

===Tolerance and addiction potential===

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Tolerance to the effects of 4-HO-EPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-EPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-EPT all psychedelics will have a reduced effect.

==~~Legal issues~~==

==Legality==

Due to its relative obscurity, the possession and sale of 4-HO-EPT is unscheduled in most countries.

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==References==

[[Category:~~Substance~~]]

[[Category:Research chemical]]

[[Category:Psychedelic]]

[[Category:Tryptamine]]

[[Category:Psychoactive substance]]

@@ Line 2: / Line 2: @@
 {{SubstanceBox/4-HO-EPT}}
-'''4-HO-EPT''' (also known as ''' 4-hydroxy-N-ethyl-N-propyltryptamine''') is a new and obscure [[hallucinogen]]ic [[psychoactive class::psychedelic]] drug of the [[chemical class::tryptamine]] class.
+''' 4-Hydroxy-N-ethyl-N-propyltryptamine''' (also known as '''4-HO-EPT''') is a novel synthetic [[psychoactive class::psychedelic]] substance of the [[chemical class::tryptamine]] chemical class that produces [[psychedelic]] effects when [[route of administration|administered]]. It is structurally related to [[psilocin]] ('''4-HO-DMT'''), the active component in [[psilocybin mushrooms]], and produces similar effects.
-It is either used recreationally or as [[entheogen]]ic compound and is typically acquired through the use of online [[research chemical]] vendors on which it first appeared as recently as mid 2016.
+Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-EPT. It has no history of human use before being sold online as a [[research chemical]] in 2016.{{citation needed}} It remains obscure and is either used recreationally or for research purposes.
 ==Chemistry==
--HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[EPT]]).
+-HO-EPT, or 4-hydroxy-N,N-diethyltryptamine, is a synthetic indole molecule of the [[tryptamine]] class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R<sub>3</sub> to an amino group via an ethyl side chain. 4-HO-EPT is substituted at R<sub>4</sub> of its indole heterocycle with a hydroxyl functional group OH−. It also contains a propyl and ethyl chain bound to the terminal amine R<sub>N</sub> of its tryptamine backbone ([[EPT]]).
 ==Pharmacology==
@@ Line 16: / Line 16: @@
 {{effectStub}}
 {{Preamble/SubjectiveEffects}}
-===Physical effects===
+{{effects/base
-*'''[[Effect::Spontaneous tactile sensations]]'''
+|{{effects/physical|
+*'''[[Effect::Spontaneous physical sensations]]'''
 *'''[[Effect::Increased heart rate]]'''
 *'''[[Effect::Nausea]]'''
 *'''[[Effect::Pupil dilation]]'''
-===Cognitive effects===
+}}
-*'''[[Effect::Conceptual thinking]]'''
+{{effects/visual|
-*'''[[Effect::Cognitive euphoria]]'''
-*'''[[Effect::Delusions]]'''
-*'''[[Effect::Emotionality enhancement]]'''
-*'''[[Effect::Immersion enhancement]]'''
-*'''[[Effect::Increased music appreciation]]'''
-*'''[[Effect::Memory suppression]]'''
-**'''[[Effect::Ego death]]'''
-*'''[[Effect::Novelty enhancement]]'''
-*'''[[Effect::Personal bias suppression]]'''
-*'''[[Effect::Thought loops]]'''
-*'''[[Effect::Time distortion]]'''
-*'''[[Effect::Unity and interconnectedness]]'''
-===Visual effects===
 ====Enhancements====
 *'''[[Effect::Colour enhancement]]'''
@@ Line 54: / Line 42: @@
 *'''[[Effect::Diffraction]]'''
-===[[Effect::Geometry]]===
+====[[Effect::Geometry]]====
 ====Hallucinatory states====
@@ Line 60: / Line 48: @@
 *'''[[Effect::Internal hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'')
-===Auditory effects===
+}}
+|{{effects/cognitive|
+*'''[[Effect::Conceptual thinking]]'''
+*'''[[Effect::Cognitive euphoria]]'''
+*'''[[Effect::Delusions]]'''
+*'''[[Effect::Emotionality enhancement]]'''
+*'''[[Effect::Immersion enhancement]]'''
+*'''[[Effect::Increased music appreciation]]'''
+*'''[[Effect::Memory suppression]]'''
+**'''[[Effect::Ego death]]'''
+*'''[[Effect::Novelty enhancement]]'''
+*'''[[Effect::Personal bias suppression]]'''
+*'''[[Effect::Thought loops]]'''
+*'''[[Effect::Time distortion]]'''
+}}
+{{effects/auditory|
 *'''[[Effect::Auditory enhancement|Enhancements]]'''
 *'''[[Effect::Auditory distortion|Distortions]]'''
 *'''[[Effect::Auditory hallucinations|Hallucinations]]'''
+}}
+{{effects/transpersonal|
+*'''[[Effect::Unity and interconnectedness]]'''
+}}
+}}
 ==Toxicity and harm potential==
 {{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
-The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-EPT is a [[research chemical]] with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+The toxicity and long-term health effects of recreational 4-HO-EPT use do not seem to have been studied in any scientific context and the exact [[Toxicity::toxic dose is unknown]]. This is because 4-HO-EPT is a [[research chemical]] with very little history of human usage.
+Anecdotal evidence from people within the community who have tried 4-HO-EPT suggests that there are no negative health effects attributed to simply trying the it by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this drug.
+It is strongly recommended that one use [[responsible drug use|harm reduction practices]] when using this substance.
 ===Tolerance and addiction potential===
@@ Line 76: / Line 88: @@
 Tolerance to the effects of 4-HO-EPT are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 4-HO-EPT presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 4-HO-EPT all psychedelics will have a reduced effect.
-==Legal issues==
+==Legality==
+{{legalStub}}
 Due to its relative obscurity, the possession and sale of 4-HO-EPT is unscheduled in most countries.
@@ Line 93: / Line 106: @@
 ==References==
 <references/>
-[[Category:Substance]]
+[[Category:Research chemical]]
 [[Category:Psychedelic]]
 [[Category:Tryptamine]]
 [[Category:Psychoactive substance]]
 {{#set:Featured=true}}