NEP: Difference between revisions

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'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[immersion enhancement|immersion enhancing]], [[euphoric]], and mild [[entactogenic]] effects when [[Routes of administration|administered]]. The stimulating effects of NEP are believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI)~~; the~~ reported entactogenic effects it displays may also be due to its activity as a [[serotonin]] [[reuptake inhibitor]] or [[releasing agent]] in moderate to high doses, although this has yet to be scientifically ~~validated~~.{{citation needed}}

'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[immersion enhancement|immersion enhancing]], [[euphoric]], and mild [[entactogenic]] effects when [[Routes of administration|administered]].

The stimulating effects of NEP are believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI). The reported entactogenic effects it displays may also be due to its activity as a [[serotonin]] [[reuptake inhibitor]] or [[releasing agent]] in moderate to high doses, although this has yet to be confirmed scientifically.{{citation needed}}

NEP shares a close structural relationship to its parent compound [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects.

NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts". As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.

NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts".

As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP in humans. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.

==Chemistry==

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 {{SubstanceBox/N-Ethyl-(nor)-pentedrone}}
-'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[immersion enhancement|immersion enhancing]], [[euphoric]], and mild [[entactogenic]] effects when [[Routes of administration|administered]]. The stimulating effects of NEP are believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI); the reported entactogenic effects it displays may also be due to its activity as a [[serotonin]] [[reuptake inhibitor]] or [[releasing agent]] in moderate to high doses, although this has yet to be scientifically validated.{{citation needed}}
+'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[immersion enhancement|immersion enhancing]], [[euphoric]], and mild [[entactogenic]] effects when [[Routes of administration|administered]].
+The stimulating effects of NEP are believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI). The reported entactogenic effects it displays may also be due to its activity as a [[serotonin]] [[reuptake inhibitor]] or [[releasing agent]] in moderate to high doses, although this has yet to be confirmed scientifically.{{citation needed}}
 NEP shares a close structural relationship to its parent compound [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects.
-NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts". As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.
+NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts".
+As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP in humans. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.
 ==Chemistry==