3-HO-PCE: Difference between revisions

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Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the [[μ-opioid]] [[receptor]] given its structural relationship to [[3-HO-PCP]], which has been shown to display affinity for the [[μ-opioid]] [[receptor]] in animal models.<ref name="3HOPCEsar">Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref> Whether it produces any of its theorized [[opioid]] effects in humans is the subject of ongoing discussion. If it does, 3-HO-PCE may pose unique risks relative to other dissociatives, particularly when it is redosed.

Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."

Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile has been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."

It should be noted that no independent lab analysis has been conducted for any of the batches that have been marketed to date.{{citation needed}} All current information regarding this compound should be regarded with extreme caution.

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 Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the [[μ-opioid]] [[receptor]] given its structural relationship to [[3-HO-PCP]], which has been shown to display affinity for the  [[μ-opioid]] [[receptor]] in animal models.<ref name="3HOPCEsar">Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref> Whether it produces any of its theorized [[opioid]] effects in humans is the subject of ongoing discussion. If it does, 3-HO-PCE may pose unique risks relative to other dissociatives, particularly when it is redosed.
-Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."
+Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile has been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."
 It should be noted that no independent lab analysis has been conducted for any of the batches that have been marketed to date.{{citation needed}} All current information regarding this compound should be regarded with extreme caution.