3-HO-PCE: Difference between revisions

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===Tolerance and addiction potential===

~~The~~ chronic use of 3-HO-PCE ~~can be considered~~ [[Addiction potential::~~highly~~ addictive with a ~~high~~ potential for adverse side effects such as psychosis]]. In comparison to other [[~~dissociative~~]]s, 3-HO-PCE has been reported to be more ~~addictive~~ than [[MXE]], [[diphenidine]], [[ephenidine]], [[DCK]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.

Early reports have characterized the chronic use of 3-HO-PCE as [[Addiction potential::moderately addictive with a moderate potential for adverse side effects such as psychosis]]. In comparison to other [[dissociatives]], 3-HO-PCE has been reported to be more potentially habit-forming than [[MXE]], [[diphenidine]], [[ephenidine]], [[DCK]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.

Tolerance to many of the effects of 3-HO-PCE ~~develops~~ [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::4 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-HO-PCE, all [[~~dissociative~~]]s will have a reduced effect.

Tolerance to many of the effects of 3-HO-PCE are expected to develop [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::4 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-HO-PCE, all [[dissociatives]] will have a reduced effect.

It is strongly recommended that one exercise extreme caution and [[responsible drug use|harm reduction]] practices when using this substance.

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*Users should avoid taking the drug multiple days in a row or becoming dependent/addicted to it as this seems to be the main common factor in the observed incidences of severe adverse effects.

*The recommended dosage range should not be exceeded as high doses can trigger these effects as well.

*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the ~~drug~~'s potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-HO-PCE (Tripsit) | https://wiki.tripsit.me/wiki/3-HO-PCE</ref>

*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the substance's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-HO-PCE (Tripsit) | https://wiki.tripsit.me/wiki/3-HO-PCE</ref>

*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.

*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose, which can potentially produce serious adverse physical side effects.

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[~~stimulant~~]]s, [[~~psychedelic~~]]s, or other [[~~dissociative]]s like [[MXE~~]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulants]], [[psychedelics]], or other [[dissociatives]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.

~~It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose~~.

===Urinary tract effects===

@@ Line 114: / Line 114: @@
 ===Tolerance and addiction potential===
-The chronic use of 3-HO-PCE can be considered [[Addiction potential::highly addictive with a high potential for adverse side effects such as psychosis]]. In comparison to other [[dissociative]]s, 3-HO-PCE has been reported to be more addictive than [[MXE]], [[diphenidine]], [[ephenidine]], [[DCK]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage. There have been multiple reports across the internet of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.
+Early reports have characterized the chronic use of 3-HO-PCE as [[Addiction potential::moderately addictive with a moderate potential for adverse side effects such as psychosis]]. In comparison to other [[dissociatives]], 3-HO-PCE has been reported to be more potentially habit-forming than [[MXE]], [[diphenidine]], [[ephenidine]], [[DCK]], and [[ketamine]]. When addiction has developed, cravings and [[withdrawal effects]] may occur if a person suddenly stops their usage.
-Tolerance to many of the effects of 3-HO-PCE develops [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::4 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-HO-PCE, all [[dissociative]]s will have a reduced effect.
+Tolerance to many of the effects of 3-HO-PCE are expected to develop [[Time to full tolerance::with prolonged and repeated use]]. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about [[Time to half tolerance::4 - 7 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::1 - 2 weeks]] to be back at baseline (in the absence of further consumption). 3-HO-PCE presents cross-tolerance with [[Cross-tolerance::all [[dissociative]]s]], meaning that after the consumption of 3-HO-PCE, all [[dissociatives]] will have a reduced effect.
 It is strongly recommended that one exercise extreme caution and [[responsible drug use|harm reduction]] practices when using this substance.
@@ Line 122: / Line 122: @@
 *Users should avoid taking the drug multiple days in a row or becoming dependent/addicted to it as this seems to be the main common factor in the observed incidences of severe adverse effects.
 *The recommended dosage range should not be exceeded as high doses can trigger these effects as well.
-*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-HO-PCE (Tripsit) | https://wiki.tripsit.me/wiki/3-HO-PCE</ref>
+*Users should start with extremely low doses and work their way up as slowly as possible. [[Volumetric liquid dosing|Volumetric liquid dosing]] should preferably be used due to the substance's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.<ref>3-HO-PCE (Tripsit) | https://wiki.tripsit.me/wiki/3-HO-PCE</ref>
-*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose.
+*[[Compulsive redosing]] before one has fully sobered up is not recommended and can result in too high of a dose, which can potentially produce serious adverse physical side effects.
-Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulant]]s, [[psychedelic]]s, or other [[dissociative]]s like [[MXE]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
+Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially [[stimulants]], [[psychedelics]], or other [[dissociatives]]. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption.
-It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.
 ===Urinary tract effects===