3-HO-PCE: Difference between revisions

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'''3-Hydroxyeticyclidine''' (commonly known as '''3-HO-PCE''') is a novel synthetic [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] chemical class that produces potent, dose-sensitive [[dissociative]], [[hallucinogenic]] and [[euphoric]] effects when [[Routes of administration|administered]]. Unlike its close structural analog [[3-HO-PCP]], this compound is entirely novel and has no precedent in the scientific literature before being offered on the research chemicals market in the 2010s.

Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the mu [[opioid]] receptor given its structural relationship to [[3-HO-PCP]], which is known to possess affinity for the mu opioid receptor.<ref>Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref> Whether it produces any of its theorized [[opioid]] effects in humans is the subject of ongoing ~~debate~~.

Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the [[μ-opioid]] [[receptor]] given its structural relationship to [[3-HO-PCP]], which is known to possess affinity for the [[μ-opioid]] [[receptor]].<ref>Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref> Whether it produces any of its theorized [[opioid]] effects in humans is the subject of ongoing discussion.

Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."

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 '''3-Hydroxyeticyclidine''' (commonly known as '''3-HO-PCE''') is a novel synthetic [[Psychoactive class::dissociative]] substance of the [[Chemical class::arylcyclohexylamine]] chemical class that produces potent, dose-sensitive [[dissociative]], [[hallucinogenic]] and [[euphoric]] effects when [[Routes of administration|administered]]. Unlike its close structural analog [[3-HO-PCP]], this compound is entirely novel and has no precedent in the scientific literature before being offered on the research chemicals market in the 2010s.
-Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the mu [[opioid]] receptor given its structural relationship to [[3-HO-PCP]], which is known to possess affinity for the mu opioid receptor.<ref>Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref> Whether it produces any of its theorized [[opioid]] effects in humans is the subject of ongoing debate.
+Early discussions of this compound have revolved around whether it possesses an appreciable affinity for the [[μ-opioid]] [[receptor]] given its structural relationship to [[3-HO-PCP]], which is known to possess affinity for the  [[μ-opioid]] [[receptor]].<ref>Kalir, A., S. Maayani, M. Rehavi, R. Elkavetz, I. Pri-Bar, O. Buchman and M. Sokolovsky, 1978, Structure activity relationship of some phencyclidine derivatives; in vivo studies in mice, European J. Med. Chem. 13, 17.</ref> Whether it produces any of its theorized [[opioid]] effects in humans is the subject of ongoing discussion.
 Following other substances of its class, particularly [[methoxetamine]] (MXE), [[phencyclidine]] (PCP), and [[3-MeO-PCE]], it is speculated to to be able to induce a state known as "[[dissociatives#Subjective effects|dissociative anesthesia]]". Early reports suggest that this state is difficult to reach relative to other [[dissociatives]], and its general effects profile been characterized as "lying halfway between [[3-MeO-PCP]] and [[3-MeO-PCE]]."