Methylnaphthidate: Difference between revisions

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~~| ''[[Methylnaphthidate/Summary|Summary sheet: Methylnaphthidate]]''~~

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'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] drug of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Concerta'').{{citation needed}}

~~The two substances are believed to have very similar core pharmacological mechanisms but have been reported~~ as ~~displaying distinctive subjective effects that~~ is ~~thought to correspond to their differing binding efficacies~~ and [[~~monoamine~~]] ~~reuptake inhibition ratios (in~~ a ~~manner similar to~~ [[~~4F-MPH~~]]) ~~but with distinctly more activity on serotonin than other, more typical methylphenidate analogs~~.~~{{citation needed}}~~

'''Methylnaphthidate''' (also known as '''HDMP-28''') is a novel synthetic [[psychoactive class::stimulant]] substance of the substituted [[chemical class::naphthidate]] and [[piperidine]] chemical classes. It is a structural analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Concerta'') that produces moderately [[stimulating]] effects when [[Routes of administration|administered]].

~~Methylnaphthidate~~ has little ~~to no~~ history of human usage ~~prior to its availability~~ by vendors on the ~~online~~ [[~~research chemical~~]] ~~market~~.

Like members of the [[phenidate]] class, methylnaphthidate is believed to act as a [[monoamine]] [[reuptake inhibitor]].{{citation needed}} However, it has been reported to display distinct differences in its subjective effects by not behaving as a traditional [[dopaminergic]] [[stimulant]]. This has been speculated to owe itself to its appreciable effects on [[serotonin]] reuptake inhibition that is not observed in typical methylphenidate analogs.{{citation needed}}

Very little data exists about the pharmacological properties, metabolism, and toxicity of methylnaphthidate, and it has little history of human usage. It is sometimes commercially distributed as a grey-area [[research chemical]] by online vendors alongside other [[methylphenidate]] analogs like [[ethylphenidate]], [[isopropylphenidate]], and [[4F-MPH]]. It is highly advised to approach this and poorly understood stimulant substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it.

==Chemistry==

~~It is only different from~~ methylphenidate in chemical substance in the ~~way that~~ the ~~benzene~~ ring ~~that normally leads into the rest of the molecule is replaced~~ with napthalene.

The main structural differences between methylnaphthidate and methylphenidate in chemical substance is the replacement of the core phenyl ring with with a napthalene group.

==Pharmacology==

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 {{headerpanel|{{approval}}}}
+{{SummarySheet}}
 {{SubstanceBox/Methylnaphthidate}}
-{|
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-| ''[[Methylnaphthidate/Summary|Summary sheet: Methylnaphthidate]]''
-|}
-'''Methylnaphthidate''' (also known as '''HDMP-28''') is a [[stimulant]] drug of the [[substituted phenethylamine]] and [[piperidine]] classes, and close analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Concerta'').{{citation needed}}
-The two substances are believed to have very similar core pharmacological mechanisms but have been reported as displaying distinctive subjective effects that is thought to correspond to their differing binding efficacies and [[monoamine]] reuptake inhibition ratios (in a manner similar to [[4F-MPH]]) but with distinctly more activity on serotonin than other, more typical methylphenidate analogs.{{citation needed}}
+'''Methylnaphthidate''' (also known as '''HDMP-28''') is a novel synthetic [[psychoactive class::stimulant]] substance of the substituted [[chemical class::naphthidate]] and [[piperidine]] chemical classes. It is a structural analog of the commonly prescribed ADHD drug [[methylphenidate]] (e.g. ''Ritalin'', ''Concerta'') that produces moderately [[stimulating]] effects when [[Routes of administration|administered]].
-Methylnaphthidate has little to no history of human usage prior to its availability by vendors on the online [[research chemical]] market.
+Like members of the [[phenidate]] class, methylnaphthidate is believed to act as a [[monoamine]] [[reuptake inhibitor]].{{citation needed}} However, it has been reported to display distinct differences in its subjective effects by not behaving as a traditional [[dopaminergic]] [[stimulant]]. This has been speculated to owe itself to its appreciable effects on [[serotonin]] reuptake inhibition that is not observed in typical methylphenidate analogs.{{citation needed}}
+Very little data exists about the pharmacological properties, metabolism, and toxicity of methylnaphthidate, and it has little history of human usage. It is sometimes commercially distributed as a grey-area [[research chemical]] by online vendors alongside other [[methylphenidate]] analogs like [[ethylphenidate]], [[isopropylphenidate]], and [[4F-MPH]]. It is highly advised to approach this and poorly understood stimulant substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it.
 ==Chemistry==
-It is only different from methylphenidate in chemical substance in the way that the benzene ring that normally leads into the rest of the molecule is replaced with napthalene.
+{{chemistry}}
+The main structural differences between methylnaphthidate and methylphenidate in chemical substance is the replacement of the core phenyl ring with with a napthalene group.
 ==Pharmacology==