This is an unofficial archive of PsychonautWiki as of 2025-08-11T15:14:44Z. Content on this page may be outdated, incomplete, or inaccurate. Please refer to the original page for the most up-to-date information.
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Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | Although many substances are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be relatively harmless in low doses of each but can still increase the risk of unpredictable injury or death. [https://www.google.com/ Independent research] should always be done to ensure that a combination of two or more substances is safe before consumption. | ||
*'''[[Tramadol]]''' - Tramadol lowers seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and psychedelics may act as triggers for seizures, particularly in those who are predisposed to them. | *'''[[Tramadol]]''' - Tramadol lowers seizure threshold<ref>Talaie, H., Panahandeh, R., Fayaznouri, M. R., Asadi, Z., & Abdollahi, M. (2009). Dose-independent occurrence of seizure with tramadol. Journal of medical toxicology, 5(2), 63-67. doi:10.1007/BF03161089</ref> and [[psychedelics]] may act as triggers for seizures, particularly in those who are predisposed to them.<ref>Fisher, D. D., & Ungerleider, J. T. (1967). [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1502729/ Grand mal seizures following ingestion of LSD]. California Medicine, 106(3), 210. PMCID: PMC1502729</ref><ref>Question ID: 2837 (Ask Erowid) | https://www.erowid.org/ask/ask.php?ID=2837</ref> | ||
*'''[[Stimulants]]''' - Combining stimulants with psychedelics may induce states of uncontrollable anxiety, over-stimulation, [[thought loops]], and increase the risk of psychosis.<ref>Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd</ref> | *'''[[Stimulants]]''' - Combining stimulants with psychedelics may induce states of uncontrollable anxiety, over-stimulation, [[thought loops]], and increase the risk of psychosis.<ref>Tripsit Factsheets - LSD | http://drugs.tripsit.me/lsd</ref> | ||
*'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}} | *'''[https://en.wikipedia.org/wiki/Lithium_(medication) Lithium]''' - Lithium is often used as treatment for bipolar disorder. It may possibly cause elevated risk of seizures and psychosis due to its [[Glutamate|glutaminergic]] and [[GABA|GABAergic]] effects.{{citation needed}} | ||