Talk:Therapeutic index: Difference between revisions

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==Applications in non-medical and recreational contexts==

The concept of a "therapeutic window" or "safety ratio" is sometimes informally applied in the psychonaut and recreational substance using community to communicate the relative degree of risks associated with the use of various [[psychoactive substances]]. These typically relate to the likelihood of experiencing desired effects (such as [[disinhibition]], [[stamina enhancement]], [[sociability enhancement]] and [[euphoria]] in the case of traditional street drugs and in the case of [[hallucinogens]] sensory distortions, [[hallucinatory states]], and [[euphoria]]) relative to the likelihood of experiencing side-effects which can range from extremely discomforting to life-threatening.

The concept of a "therapeutic window" or "safety ratio" is sometimes informally applied in the psychonaut and recreational substance using community to communicate the relative degree of risks associated with the use of various [[psychoactive substances]]. These typically relate to the likelihood of experiencing desired effects (such as [[disinhibition]], [[stamina enhancement]], [[sociability enhancement]] and [[euphoria]] in the case of traditional street drugs and, in the case of [[hallucinogens]], sensory distortions, [[hallucinatory states]], and [[euphoria]]) relative to the likelihood of experiencing side-effects which can range from extremely discomforting to life-threatening.

While the exact values for the safety ratios of psychoactive substances are rarely, if ever, referenced (and many are not even available given the prevalence of novel substances and the lack of pharmacological and toxicological data on them), the notion of a particular substance possessing a "high" or "low" safety ratio can serve to inform users about whether they want to experiment with a substance given their own personal comfort levels and degree of acceptable risk they are willing to take.

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 ==Applications in non-medical and recreational contexts==
-The concept of a "therapeutic window" or "safety ratio" is sometimes informally applied in the psychonaut and recreational substance using community to communicate the relative degree of risks associated with the use of various [[psychoactive substances]]. These typically relate to the likelihood of experiencing desired effects (such as [[disinhibition]], [[stamina enhancement]], [[sociability enhancement]] and [[euphoria]] in the case of traditional street drugs and in the case of [[hallucinogens]] sensory distortions, [[hallucinatory states]], and [[euphoria]]) relative to the likelihood of experiencing side-effects which can range from extremely discomforting to life-threatening.
+The concept of a "therapeutic window" or "safety ratio" is sometimes informally applied in the psychonaut and recreational substance using community to communicate the relative degree of risks associated with the use of various [[psychoactive substances]]. These typically relate to the likelihood of experiencing desired effects (such as [[disinhibition]], [[stamina enhancement]], [[sociability enhancement]] and [[euphoria]] in the case of traditional street drugs and, in the case of [[hallucinogens]], sensory distortions, [[hallucinatory states]], and [[euphoria]]) relative to the likelihood of experiencing side-effects which can range from extremely discomforting to life-threatening.
 While the exact values for the safety ratios of psychoactive substances are rarely, if ever, referenced (and many are not even available given the prevalence of novel substances and the lack of pharmacological and toxicological data on them), the notion of a particular substance possessing a "high" or "low" safety ratio can serve to inform users about whether they want to experiment with a substance given their own personal comfort levels and degree of acceptable risk they are willing to take.