Talk:Therapeutic index: Difference between revisions

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Examples of this include knowing the general dosage of any particular substance liable to put one at risk of an overdose, particularly those that can be sudden and fatal, such as those associated with [[opioids]] like [[heroin]] and [[stimulants]] like [[cocaine]]. In the case of [[hallucinogens]], a substance may have a very low safety ratio, such as [[LSD]], which has no established, reasonable lethal dose{{citation needed}}) relative to a [[25x-NBOMe]] substance, in which the dose needed to produce the desired psychoactivity is only a few multipliers lower than a dose which can produce [[seizures]], coma or death.{{citation needed}} For this reason, the NBOMe family of psychedelic substances are considered to be significantly more dangerous to use than [[LSD]] despite sharing many [[psychedelic]] properties that can be difficult to distinguish, particularly for inexperienced users.

Likewise, the three major subclasses of [[hallucinogens]] (i.e. [[psychedelics]], [[dissociatives]], and [[deliriants]]) are each associated with their own generalized safety ratios. For example, substances in the [[deliriant]] subclass such as [[diphenhydramine]], [[benzydamine]], and [[datura]] are associated with higher degrees of physical toxicity at doses which produce the desired hallucinogenic effects and are thus considered to have the lowest safety ratio, which means a greater amount of precaution and preparation ([[harm reduction practices]]) must be undertaken if one chooses to experiment with them. [[Psychedelics]] and [[dissociatives]] tend to have higher safety ratios.

Likewise, the three major subclasses of [[hallucinogens]] (i.e. [[psychedelics]], [[dissociatives]], and [[deliriants]]) are each associated with their own generalized safety ratios. For example, substances in the [[deliriant]] subclass such as [[diphenhydramine]], [[benzydamine]], and [[datura]] are associated with higher degrees of physical toxicity at doses which produce the desired hallucinogenic effects and are thus considered to have the lowest safety ratio, which means a greater amount of precaution and preparation ([[harm reduction practices]]) must be undertaken if one chooses to experiment with them. [[Psychedelics]] and [[dissociatives]] tend to have higher safety ratios.{{citation needed}}

It should be noted that this pharmacological concept is limited in its scope when determining the total degree of risk or safety associated with hallucinogen use, as the low risk of physical overdose does not mitigate the profound changes in perception and cognition which when produced, can lead to dangerous [[delusions|delusional]], [[psychosis|psychotic]], or [[amnesia|amnesic]] states leading to behaviors that result in physical or psychological injury or death. Examples of this include walking into moving traffic or driving while intoxicated.

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 Examples of this include knowing the general dosage of any particular substance liable to put one at risk of an overdose, particularly those that can be sudden and fatal, such as those associated with [[opioids]] like [[heroin]] and [[stimulants]] like [[cocaine]]. In the case of [[hallucinogens]], a substance may have a very low safety ratio, such as [[LSD]], which has no established, reasonable lethal dose{{citation needed}}) relative to a [[25x-NBOMe]] substance, in which the dose needed to produce the desired psychoactivity is only a few multipliers lower than a dose which can produce [[seizures]], coma or death.{{citation needed}} For this reason, the NBOMe family of psychedelic substances are considered to be significantly more dangerous to use than [[LSD]] despite sharing many [[psychedelic]] properties that can be difficult to distinguish, particularly for inexperienced users.
-Likewise, the three major subclasses of [[hallucinogens]] (i.e. [[psychedelics]], [[dissociatives]], and [[deliriants]]) are each associated with their own generalized safety ratios. For example, substances in the [[deliriant]] subclass such as [[diphenhydramine]], [[benzydamine]], and [[datura]] are associated with higher degrees of physical toxicity at doses which produce the desired hallucinogenic effects and are thus considered to have the lowest safety ratio, which means a greater amount of precaution and preparation ([[harm reduction practices]]) must be undertaken if one chooses to experiment with them. [[Psychedelics]] and [[dissociatives]] tend to have higher safety ratios.
+Likewise, the three major subclasses of [[hallucinogens]] (i.e. [[psychedelics]], [[dissociatives]], and [[deliriants]]) are each associated with their own generalized safety ratios. For example, substances in the [[deliriant]] subclass such as [[diphenhydramine]], [[benzydamine]], and [[datura]] are associated with higher degrees of physical toxicity at doses which produce the desired hallucinogenic effects and are thus considered to have the lowest safety ratio, which means a greater amount of precaution and preparation ([[harm reduction practices]]) must be undertaken if one chooses to experiment with them. [[Psychedelics]] and [[dissociatives]] tend to have higher safety ratios.{{citation needed}}
 It should be noted that this pharmacological concept is limited in its scope when determining the total degree of risk or safety associated with hallucinogen use, as the low risk of physical overdose does not mitigate the profound changes in perception and cognition which when produced, can lead to dangerous [[delusions|delusional]], [[psychosis|psychotic]], or [[amnesia|amnesic]] states leading to behaviors that result in physical or psychological injury or death. Examples of this include walking into moving traffic or driving while intoxicated.