25I-NBOMe: Difference between revisions

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'''25I-NBOMe''' (also known as '''2C-I-NBOMe''', '''Cimbi-5''' and '''N-Bomb''', although this term is also commonly referred to other members of the [[25x-NBOMe]] family) is novel synthetic [[Psychoactive class::psychedelic]] of the [[chemical class::phenethylamine]] chemical class. It produces ~~a notable~~ array of visual-dominant [[psychedelic]] ~~as well as~~ [[stimulating]] effects when [[Routes of administration|administered]].

'''25I-NBOMe''' (also known as '''2C-I-NBOMe''', '''Cimbi-5''' and '''N-Bomb''', although this term is also commonly referred to other members of the [[25x-NBOMe]] family) is novel synthetic [[Psychoactive class::psychedelic]] of the [[chemical class::phenethylamine]] chemical class. It produces an array of visual-dominant [[psychedelic]] and prominent [[stimulating]] effects when [[Routes of administration|administered]].

The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic [[2C-I]]. It first synthesized and documented in 2003 by Ralf Heim at the Free University of Berlin,<ref name="Ralf Heim PhD. (2010-02-28)">Ralf Heim PhD. (2010-02-28) "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts." | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001221 (in German). diss.fu-berlin.de. Retrieved 2013-05-10.</ref> and subsequently investigated by a team at Purdue University led by psychedelics chemist and researcher [[David E. Nichols]] as a research tool to map out the [[serotonin]] receptor system.<ref name="Michael Robert Braden PhD. (2007)">Michael Robert Braden PhD. (2007). "Towards a biophysical understanding of hallucinogen action." | http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Purdue University. Retrieved 2012-08-08.</ref>

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It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family are not [[orally]] active and should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. 25I-NBOMe can also be vaporized and inhaled; this is known to cause significantly more rapid and powerful effects and a shorter duration. However, this route of administration is heavily advised against due to the difficulties of measuring and handling substances that both have a low [[therapeutic index]] and are also active in the microgram range.

In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency, allowing even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that numbs the location of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate [[reagent testing kit]] due to the hazards this substance can pose.

In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency, allowing even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that numbs the location of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate reagent testing kit due to the hazards this substance can pose.

This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans, and has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.

This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans, and it has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.

==Chemistry==

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 {{SummarySheet}}
 {{SubstanceBox/25I-NBOMe}}
-'''25I-NBOMe''' (also known as '''2C-I-NBOMe''', '''Cimbi-5''' and '''N-Bomb''', although this term is also commonly referred to other members of the [[25x-NBOMe]] family) is novel synthetic [[Psychoactive class::psychedelic]] of the [[chemical class::phenethylamine]] chemical class. It produces a notable array of visual-dominant [[psychedelic]] as well as [[stimulating]] effects when [[Routes of administration|administered]].
+'''25I-NBOMe''' (also known as '''2C-I-NBOMe''', '''Cimbi-5''' and '''N-Bomb''', although this term is also commonly referred to other members of the [[25x-NBOMe]] family) is novel synthetic [[Psychoactive class::psychedelic]] of the [[chemical class::phenethylamine]] chemical class. It produces an array of visual-dominant [[psychedelic]] and prominent [[stimulating]] effects when [[Routes of administration|administered]].
 The name 25I-NBOMe, which short-hand for 2C-I-NBOMe, is a derivative of the phenethylamine psychedelic [[2C-I]]. It first synthesized and documented in 2003 by Ralf Heim at the Free University of Berlin,<ref name="Ralf Heim PhD. (2010-02-28)">Ralf Heim PhD. (2010-02-28) "Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts." | http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000001221 (in German). diss.fu-berlin.de. Retrieved 2013-05-10.</ref> and subsequently investigated by a team at Purdue University led by psychedelics chemist and researcher [[David E. Nichols]] as a research tool to map out the [[serotonin]] receptor system.<ref name="Michael Robert Braden PhD. (2007)">Michael Robert Braden PhD. (2007). "Towards a biophysical understanding of hallucinogen action." | http://proquest.umi.com/pqdlink?Ver=1&Exp=01-23-2014&FMT=7&DID=1417800971&RQT=309&attempt=1&cfc=1 Purdue University. Retrieved 2012-08-08.</ref>
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 It is worth noting that compounds of the [[25x-NBOMe|NBOMe]] family are not [[orally]] active and should be administered [[sublingual|sublingually]] by placing and holding it into one's mouth and allowing it to absorb over a period of 15-25 minutes. 25I-NBOMe can also be vaporized and inhaled; this is known to cause significantly more rapid and powerful effects and a shorter duration. However, this route of administration is heavily advised against due to the difficulties of measuring and handling substances that both have a low [[therapeutic index]] and are also active in the microgram range.
-In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency, allowing even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that numbs the location of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate [[reagent testing kit]] due to the hazards this substance can pose.
+In comparison to [[2C-I]], the addition of an NBOMe group to the structure results in a sixteen-fold increase in potency, allowing even the heaviest of dosages to fit in liquid form onto tabs and blotter paper, which are often misrepresented or mistaken for [[LSD]]. In contrast to LSD, 25i-NBOMe has a distinctly bitter and metallic taste that numbs the location of the mouth it is applied to. This property is often used as a makeshift test for its authenticity but is generally advised against. Users instead are encouraged to test all of their blotters through a drug testing service or with the appropriate reagent testing kit due to the hazards this substance can pose.
-This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans, and has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.
+This substance had no history of human use before being sold online as a [[designer drug]] in 2010.{{citation needed}} Extremely little is known about the pharmacological properties, metabolism, and toxicity of 25I-NBOMe in humans, and it has been associated with many deaths and hospitalizations. Along with its highly sensitive dose-response and unpredictable effects, many reports also suggest that this substance may be overly difficult to use safely. Therefore it is highly advised to approach this poorly understood [[psychedelic]] substance with the proper amount of precaution and [[Responsible drug use#Hallucinogens|harm reduction practices]] if choosing to use it.
 ==Chemistry==