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2C-T-2: Difference between revisions

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Summary - Stolaroff's work
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Cite placements. Grammatics. Minor effects expansion, implemented transpersonal effects. "Dangerous interactions" under Tox. Hallucinogen category added. "Legal issues" -> "Legality".
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{{SubstanceBox/2C-T-2}}
{{SubstanceBox/2C-T-2}}


'''2,5-Dimethoxy-4-ethylthiophenethylamine''' (also known as '''2C-T-2''', and '''Rosy''') is a [[Psychoactive class::psychedelic]] [[Chemical class::phenethylamine]] of the [[2C-x]] family. It was first synthesized and tested for activity in humans by [[Alexander Shulgin]] and his research group in 1981<ref>Shulgin, Alexander. "Pharmacology Lab Notes #4". Lafayette, CA. (1981-1982). p474 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_pharmacology_notebook4_searchable.pdf</ref>. Shulgin described the synthesis and activity of 2C-T-2 in his 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved")<ref>https://erowid.org/library/books_online/pihkal/pihkal.shtml | [[PiHKAL]] </ref>.
'''2,5-Dimethoxy-4-ethylthiophenethylamine''' (also known as '''2C-T-2''', and '''Rosy''') is a [[Psychoactive class::psychedelic]] [[Chemical class::phenethylamine]] of the [[2C-x]] family. It was first synthesized and tested for activity in humans by [[Alexander Shulgin]] and his research group in 1981.<ref>Shulgin, Alexander. "Pharmacology Lab Notes #4". Lafayette, CA. (1981-1982). p474 (Erowid.org) | https://erowid.org/library/books_online/shulgin_labbooks/shulgin_pharmacology_notebook4_searchable.pdf</ref> Shulgin described the synthesis and activity of 2C-T-2 in his 1991 book [[PiHKAL]] ("Phenethylamines I Have Known and Loved").<ref>https://erowid.org/library/books_online/pihkal/pihkal.shtml | [[PiHKAL]] </ref>


This particular substance is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which, with the exception of [[mescaline]] he developed and synthesized himself. They can be found within the first book of PiHKAL, and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], [[2C-E]], [[2C-T-2]] and [[2C-T-7]].<ref>https://erowid.org/library/books_online/pihkal/pihkal.shtml | [[PiHKAL]] </ref>
This particular substance is part of the so-called "magical half-dozen" which refers to Shulgin's self-rated most important phenethylamine compounds, all of which, with the exception of [[mescaline]] he developed and synthesized himself. They can be found within the first book of PiHKAL, and are as follows: [[Mescaline]], [[DOM]], [[2C-B]], [[2C-E]], [[2C-T-2]] and [[2C-T-7]].<ref>https://erowid.org/library/books_online/pihkal/pihkal.shtml | [[PiHKAL]] </ref>


Anecdotal reports tend to characterize 2C-T-2 as a highly dose sensitive psychedelic known for its strong visuals and unpredictably intense body load.  
Anecdotal reports tend to characterize 2C-T-2 as a highly dose sensitive psychedelic known for its strong visuals, lucid headspace and unpredictably intense [[body load]].  


Following the initial positive results found by Shulgin's research group, a more formal study was carried out by psychedelic psychotherapy pioneer by Myron J. Stolaroff who was interested in evaluating the potential use of 2C-T-2 in psychotherapy<ref>Stolaroff, MJ; Wells, C. Preliminary results with new psychoactive agents 2C-T-2 and 2C-T-7. In Jahrbuch für Ethnomedizin und Bewußtseinsforschung (Yearbook of Ethnomedicine and the Study of Consciousness); Rätsch, C; Baker, J, Eds., 1993; Vol. 2, pp 99–117. (MAPS.org) | http://www.maps.org/images/pdf/1993_stolaroff_1.pdf</ref>. Based on the experiences of forty participants in the study who took 2C-T-2, Stolaroff compared the effects favourably to [[MDMA]], describing it as more emotionally opening and permitting a wider exploration of feelings and thoughts. Although presenting a very positive evaluation of the drug, Stolaroff also noted that because it permitted repressed feelings to surface more readily than MDMA, the experience could be uncomfortable for some users.  
Following the initial positive results found by Shulgin's research group, a more formal study was carried out by psychedelic psychotherapy pioneer by Myron J. Stolaroff who was interested in evaluating the potential use of 2C-T-2 in psychotherapy.<ref>Stolaroff, MJ; Wells, C. Preliminary results with new psychoactive agents 2C-T-2 and 2C-T-7. In Jahrbuch für Ethnomedizin und Bewußtseinsforschung (Yearbook of Ethnomedicine and the Study of Consciousness); Rätsch, C; Baker, J, Eds., 1993; Vol. 2, pp 99–117. (MAPS.org) | http://www.maps.org/images/pdf/1993_stolaroff_1.pdf</ref> Based on the experiences of forty participants in the study who took 2C-T-2, Stolaroff compared the effects favorably to [[MDMA]], describing it as more emotionally opening and permitting a wider exploration of feelings and thoughts. Although presenting a very positive evaluation of the drug, Stolaroff also noted that because it permitted repressed feelings to surface more readily than MDMA, the experience could be uncomfortable for some users.  


Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has little history of human usage. Many reports also indicate that the physical effects are too severe for those who are not already experienced with [[psychedelics]] or suffer from pre-existing physical conditions as it is known to cause powerful [[nausea]] and general bodily discomfort that may dominate the rest of the experience.  It is highly advised to approach this potent, physically unpredictable, and long-lived [[psychedelic]] substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 2C-T-2, and it has little history of human usage. Many reports also indicate that the physical effects are too severe for those who are not already experienced with [[psychedelics]] or suffer from pre-existing physical conditions as it is known to cause powerful [[nausea]] and general bodily discomfort that may dominate the rest of the experience.  It is highly advised to approach this potent, physically unpredictable, and long-lived [[psychedelic]] substance with the proper amount of precaution and [[harm reduction practices]] if choosing to use it.
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===Physical effects===
===Physical effects===
*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of 2C-T-2 can be described as very intense and uncomfortable in comparison to [[2C-E]] or [[2C-B]]. In high doses, it's capable of causing painful cramping. It is similar yet distinct from the "body high" experienced on [[2C-T-7]], but is considered much more unpleasant. The sensation itself can be described as intense and may manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
*'''[[Effect::Spontaneous tactile sensations]]''' - The "body high" of 2C-T-2 can be described as very intense and uncomfortable in comparison to [[2C-E]] or [[2C-B]]. In high doses, it's capable of causing painful cramping. It is similar yet distinct from the "body high" experienced on [[2C-T-7]], but is considered much more unpleasant. The sensation itself can be described as intense and may manifest itself in the form of a continuously shifting tingling sensation that travels up and down the body in spontaneous waves.
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the tripper, 2C-T-2 is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of other [[phenethylamines]] such as [[2C-B]], [[2C-E]] and [[2C-P]].  
*'''[[Effect::Stimulation]]''' - In terms of its effects on the physical energy levels of the user, 2C-T-2 is usually considered to be very energetic and stimulating in a fashion that is quite comparable to that of other [[phenethylamines]] such as [[2C-B]], [[2C-E]] and [[2C-P]].  
*'''[[Effect::Bodily control enhancement]]''' - Although this component is capable of manifesting itself in a distinct and noticeable fashion for most users, it does not generally seem to be as apparent or intense as the same component found within [[LSD]] and [[2C-B]].
*'''[[Effect::Bodily control enhancement]]''' - Although this component is capable of manifesting itself in a distinct and noticeable fashion for most users, it does not generally seem to be as apparent or intense as the same component found within [[LSD]] and [[2C-B]].
*'''[[Effect::Tactile enhancement]]'''
*'''[[Effect::Tactile enhancement]]'''
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*'''[[Effect::Vasoconstriction]]'''
*'''[[Effect::Vasoconstriction]]'''
*'''[[Effect::Temperature regulation suppression]]'''
*'''[[Effect::Temperature regulation suppression]]'''
**'''[[Effect::Increased bodily temperature]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Increased heart rate]]'''
*'''[[Effect::Pupil dilation]]'''
*'''[[Effect::Pupil dilation]]'''
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*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Emotionality enhancement]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Novelty enhancement]]'''
*'''[[Effect::Time distortion]]'''
*'''[[Effect::Time distortion]]'''
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*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Conceptual thinking]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased music appreciation]]'''
*'''[[Effect::Increased sense of humor]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Immersion enhancement]]'''
*'''[[Effect::Memory suppression]]'''
*'''[[Effect::Memory suppression]]'''
**'''[[Effect::Ego death]]'''
**'''[[Effect::Ego death]]'''
*'''[[Effect::Thought loops|Thought loops]]'''
*'''[[Effect::Thought acceleration]]'''
*'''[[Effect::Perception of interdependent opposites|Perception of interdependent opposites]]'''
*'''[[Effect::Thought loops]]'''
*'''[[Effect::Delusions]]'''
*'''[[Effect::Delusions]]'''
*'''[[Effect::Unity and interconnectedness]]'''
*'''[[Effect::Wakefulness]]'''
*'''[[Effect::Wakefulness]]'''


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====[[Effect::Geometry]]====
====[[Effect::Geometry]]====
The visual geometry that is present throughout this trip can be described as somewhat similar in appearance to that of [[ayahuasca]], [[psilocin]], and [[4-AcO-DMT]] with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of [[LSD]] or [[2C-E]]. 2C-T-2's geometry can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of [[DOC]] or [[2C-P]]. Higher doses are more likely to result in states of [[Effect::8B geometry|level 8B]] visual geometry, but may also lead into [[level 8A]] visual geometry (as with [[2C-T-7]]).
The visual geometry that is present throughout this experience can be described as somewhat similar in appearance to that of [[ayahuasca]], [[psilocin]], and [[4-AcO-DMT]] with mystical and shamanic undertones which combine with synthetic digital undertones reminiscent of [[LSD]] or [[2C-E]]. 2C-T-2's geometry can be comprehensively described through its [[Visual_effects:_Geometry#Variations|variations]] as intricate in complexity, abstract in form, organic but somewhat synthetic in style, structured in organization, brightly lit and multicoloured in scheme, glossy in shading, rounded in edges, large in size, fast in speed, smooth in motion, mostly angular in corners, immersive in-depth and consistent in intensity. The visuals have a contradictory natural and synthetic feel to them which is reminiscent of [[DOC]] or [[2C-P]]. Higher doses are more likely to result in states of [[Effect::8B geometry|level 8B]] visual geometry, but may also lead into [[level 8A]] visual geometry (as with [[2C-T-7]]).


====Hallucinatory states====
====Hallucinatory states====
2C-T-2 produces a full range of high level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the [[phenethylamines|phenethylamine]] family. These effects include:
At common to high doses, 2C-T-2 is capable of producing a full range of high-level hallucinatory states in a fashion that is more consistent and reproducible than that of many other commonly used psychedelics. This holds particularly true in comparison to other substances within the [[phenethylamines]] family. These effects include:
*'''[[Effect::Transformations]]'''
*'''[[Effect::Transformations]]'''
*'''[[Effect::External hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other psychedelics such as [[ayahuasca]], 2C-T-2 is very high in external hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and [[autonomous entity]] contact manifested as dense solidified geometric matter or physical objects of imagined concepts. They are more common within dark environments and can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
*'''[[Effect::External hallucinations]]''' (''[[effect::autonomous entities]]''; ''[[effect::settings, sceneries, and landscapes]]''; ''[[effect::alterations in perspective]]'' and ''[[effect::scenarios and plots]]'') - In comparison to other psychedelics such as [[ayahuasca]], 2C-T-2 is very high in external hallucinations. This particular effect commonly contains hallucinations with scenarios, settings, concepts and [[autonomous entity]] contact manifested as dense solidified geometric matter or physical objects of imagined concepts. They are more common within dark environments and can be described as external in their manifestation, lucid in believability, interactive in style and almost exclusively of a personal, religious, spiritual, science-fiction, fantasy, surreal, nonsensical or transcendental nature in their overall theme.
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*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory distortion|Distortions]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
*'''[[Effect::Auditory hallucinations|Hallucinations]]'''
===[[Transpersonal]] effects===
*'''[[Effect::Existential self-realization]]'''
*'''[[Effect::Perception of interdependent opposites]]'''
*'''[[Effect::Unity and interconnectedness]]'''


===Experience reports===
===Experience reports===
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* [https://www.erowid.org/experiences/subs/exp_2CT2.shtml Erowid Experience Vaults: 2C-T-2]
* [https://www.erowid.org/experiences/subs/exp_2CT2.shtml Erowid Experience Vaults: 2C-T-2]


==Potentially dangerous interactions==
==Toxicity and harm potential==
{{Template:DangerousInteractions/Intro}}
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 2C-T-2 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried 2C-T-2 within the [[psychedelic]] community suggests that there are [[Toxicity::no negative health effects attributed to trying this drug]], but nothing can be completely guaranteed.
 
It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.
===Tolerance and addiction potential===
2C-T-2 is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.


If 2C-T-2 does have [[MAOI]] effects, this could indicate that 2C-T-2 is more likely to induce [[serotonin syndrome]] or general [[neurotransmitter]] overload (especially at high dosages) than other [[serotonergic psychedelic]]s.<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109</ref> This may make it dangerous to combine it with other [[MAOI]]s, [[stimulant]]s and certain substances which releases neurotransmitters such as [[serotonin]] or [[dopamine]]. These substances include but are not limited to:
Tolerance to the effects of 2C-T-2 are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-T-2 presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-T-2 all psychedelics will have a reduced effect.
 
===Dangerous interactions===
{{DangerousInteractions/Intro}}
 
If 2C-T-2 does have [[MAOI]] effects as has been speculated,{{citation needed}} this could indicate that 2C-T-2 is more likely to induce [[serotonin syndrome]] or general [[neurotransmitter]] overload (especially at high dosages) than other [[serotonergic psychedelics]].<ref>Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors:  Biological Activities, CoMFA Analysis, and Active Site Modeling | http://pubs.acs.org/doi/abs/10.1021/jm0493109</ref> This may make it dangerous to combine it with other [[MAOIs]], [[stimulant]]s and certain substances which promotes the release of neurotransmitters such as [[serotonin]] or [[dopamine]]. These substances include but are not limited to:
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==Toxicity and harm potential==
==Legality==
{{further|Research chemicals#Toxicity and harm potential|Responsible use #Hallucinogens}}
The toxicity and long-term health effects of recreational 2C-T-2 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried 2C-T-2 within the [[psychedelic]] community suggests that there are [[Toxicity::no negative health effects attributed to trying this drug]], but nothing can be completely guaranteed.
 
It is strongly recommended that one use [[responsible drug use|harm reduction practices]], such as [[volumetric dosing]], when using this substance to ensure the administration of the intended dose.
===Tolerance and addiction potential===
2C-T-2 is [[Addiction potential::not habit-forming]] and the desire to use it can actually decrease with use. It is most often self-regulating.
 
Tolerance to the effects of 2C-T-2 are built [[Time to full tolerance::almost immediately after ingestion]]. After that, it takes about [[Time to half tolerance::3 days]] for the tolerance to be reduced to half and [[Time to zero tolerance::7 days]] to be back at baseline (in the absence of further consumption). 2C-T-2 presents cross-tolerance with [[Cross-tolerance::all [[psychedelic]]s]], meaning that after the consumption of 2C-T-2 all psychedelics will have a reduced effect.
 
==Legal issues==
*'''United Kingdom.:''' 2C-T-2 is a Class A substance, making it illegal to possess, manufacture, or import.
*'''United Kingdom.:''' 2C-T-2 is a Class A substance, making it illegal to possess, manufacture, or import.
*'''United States:''' 2C-T-2 is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.
*'''United States:''' 2C-T-2 is a Schedule 1 drug in the U.S., making it illegal to possess, manufacture, or import.
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[[Category:Phenethylamine]]
[[Category:Phenethylamine]]
[[Category:Psychedelic]]
[[Category:Psychedelic]]
[[Category:Hallucinogen]]


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