5-Hydroxytryptophan: Difference between revisions

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The psychoactive action of 5-HTP is derived from its increase in production of [[serotonin]] in central nervous system tissue. 5-HTP is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme 'aromatic-L-amino-acid decarboxylase', with the help of vitamin B6.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6983619 | Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats.</ref> This reaction occurs both in nervous tissue and in the liver.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6974228 | Characteristics of dihydroxyphenylalanine/5-hydroxytryptophan decarboxylase activity in brain and liver of cat.</ref> 5-HTP crosses the blood–brain barrier, while 5-HT (serotonin) does not.<ref>https://www.ncbi.nlm.nih.gov/pubmed/18445233 | Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat.</ref>

Excess 5-HTP, especially when administered with vitamin B6, is thought to be metabolized and excreted.<ref>Biochemical properties and kinetic parameters of dihydroxyphenylalanine--5-hydroxytryptophan decarboxylase in brain, liver, and adrenals of cat | doi=10.1139/o79-126}}</ref><ref>~~title=~~On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression ~~| |pmid=1088369~~ </ref>

Excess 5-HTP, especially when administered with vitamin B6, is thought to be metabolized and excreted.<ref>Biochemical properties and kinetic parameters of dihydroxyphenylalanine--5-hydroxytryptophan decarboxylase in brain, liver, and adrenals of cat | doi=10.1139/o79-126}}</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/1088369 | On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression</ref>

==Subjective effects==

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 The psychoactive action of 5-HTP is derived from its increase in production of [[serotonin]] in central nervous system tissue. 5-HTP is decarboxylated to serotonin (5-hydroxytryptamine or 5-HT) by the enzyme 'aromatic-L-amino-acid decarboxylase', with the help of vitamin B<sub>6</sub>.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6983619 | Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats.</ref> This reaction occurs both in nervous tissue and in the liver.<ref>https://www.ncbi.nlm.nih.gov/pubmed/6974228 | Characteristics of dihydroxyphenylalanine/5-hydroxytryptophan decarboxylase activity in brain and liver of cat.</ref> 5-HTP crosses the blood–brain barrier, while 5-HT (serotonin) does not.<ref>https://www.ncbi.nlm.nih.gov/pubmed/18445233 | Augmented brain 5-HT crosses the blood-brain barrier through the 5-HT transporter in rat.</ref>
-Excess 5-HTP, especially when administered with vitamin B<sub>6</sub>, is thought to be metabolized and excreted.<ref>Biochemical properties and kinetic parameters of dihydroxyphenylalanine--5-hydroxytryptophan decarboxylase in brain, liver, and adrenals of cat | doi=10.1139/o79-126}}</ref><ref>title=On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression | |pmid=1088369 </ref>
+Excess 5-HTP, especially when administered with vitamin B<sub>6</sub>, is thought to be metabolized and excreted.<ref>Biochemical properties and kinetic parameters of dihydroxyphenylalanine--5-hydroxytryptophan decarboxylase in brain, liver, and adrenals of cat | doi=10.1139/o79-126}}</ref><ref>https://www.ncbi.nlm.nih.gov/pubmed/1088369 | On the tryptophan-serotonin metabolism in manic-depressive disorders. Changes in plasma 5-HT and 5-HIAA levels and urinary 5-HIAA excretion following oral loading of L-5HTP in patients with depression</ref>
 ==Subjective effects==