NEP: Difference between revisions

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~~{{distinguish2|[[Pentedrone]]}}~~

'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting~~]], [[thought acceleration|thought accelerating~~]], [[immersion enhancement|immersion enhancing]] and [[~~euphoria|euphoria|~~euphoric]] effects when [[Routes of administration|administered]]. The ~~effects of~~ stimulating effects of NEP is believed to be caused by its ~~affinity~~ as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI); ~~however, there have been no scientific studies confirming this. It~~ may also act as a serotonin reuptake inhibitor or releasing agent in moderate to high doses, although this ~~also~~ has yet to be scientifically validated.

'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[immersion enhancement|immersion enhancing]] and [[euphoric]] effects when [[Routes of administration|administered]]. The stimulating effects of NEP is believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI); it may also act as a serotonin reuptake inhibitor or releasing agent in moderate to high doses, although this has yet to be scientifically validated.{{citation needed}}

NEP shares a close structural relationship to [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects.

NEP shares a close structural relationship to its parent compound [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects.

NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts".As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.

NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts". As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.

==Chemistry==

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-{{distinguish2|[[Pentedrone]]}}
 {{SummarySheet}}
 {{SubstanceBox/N-Ethyl-(nor)-pentedrone}}
-'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[thought acceleration|thought accelerating]], [[immersion enhancement|immersion enhancing]] and [[euphoria|euphoria|euphoric]] effects when [[Routes of administration|administered]]. The effects of stimulating effects of NEP is believed to be caused by its affinity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI); however, there have been no scientific studies confirming this. It may also act as a serotonin reuptake inhibitor or releasing agent in moderate to high doses, although this also has yet to be scientifically validated.
+'''N-Ethyl-(nor)-pentedrone''' (also known as '''N-Ethylpentedrone''', '''Ethyl-pentedrone''' or more commonly, '''NEP''') is a novel synthetic [[psychoactive class::stimulant]] substance of the [[psychoactive class::cathinone]] chemical class that produces [[cathinone]]-like [[stimulating]], [[disinhibition|disinhibiting]], [[immersion enhancement|immersion enhancing]] and [[euphoric]] effects when [[Routes of administration|administered]]. The stimulating effects of NEP is believed to mainly be caused by its activity as a [[norepinephrine]]-[[dopamine]] [[reuptake inhibitor]] (NDRI); it may also act as a serotonin reuptake inhibitor or releasing agent in moderate to high doses, although this has yet to be scientifically validated.{{citation needed}}
-NEP shares a close structural relationship to [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects.
+NEP shares a close structural relationship to its parent compound [[pentedrone]], differing by an addition ethyl group on the terminal nitrogen on the carbon chain. This addition reportedly makes it about three times as potent as pentedrone.{{citation needed}} NEP is also closely related to [[N-Ethylhexedrone]] (commonly known as ''Hexen''), and has been reported as producing largely-similar effects.
-NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts".As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.
+NEP first became known in the [[research chemical]] market during 2016. It is an example of a contemporary [[designer drug]] specifically chosen to mimic/replace the functional and structural features of its popular potent and short-lived-type stimulant predecessors, which are sometimes imprecisely referred to as "bath salts". As with its parent compound [[pentedrone]], very little data exists about the pharmacological properties, metabolism, and toxicity of NEP. Due to its novelty and extremely short history of human usage, all information related to the use of this compound should be treated with extreme caution. It is highly advised that one use [[responsible drug use|harm reduction practices]] if choosing to use this substance.
 ==Chemistry==